{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:01:44Z","timestamp":1791302504773,"version":"4.1.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":3440,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      The major concern of living donor liver transplantation is small-for-size graft injury at the early phase after transplantation. Novel therapeutic strategies should be developed. To investigate the protective effect of somatostatin related to hemodynamic stress on small-for-size liver graft injury, we applied a treatment regimen of low-dose somatostatin in a rat orthotopic liver transplantation model using small-for-size grafts (median, 38.7%; range, 35\u201342%). Somatostatin was given at 5 minutes before total hepatectomy and immediately after reperfusion in the recipient (20 \u03bcg\/kg). Graft survival, portal hemodynamics, intragraft gene expression and hepatic ultrastructural changes were compared between the rats with or without somatostatin treatment. Seven-day graft survival rates in the somatostatin treatment group were significantly improved compared to the control group (66.7% vs. 16.7%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.036). In the treatment group, portal pressure and hepatic surface blood flow were significantly decreased within the first 30 minutes after reperfusion, whereas in the control group, transient portal hypertension and excessive hepatic blood flow were observed. Intragraft expression (both messenger RNA and protein) of endothelin-1 was significantly downregulated accompanied with upregulation of heme oxygenase-1 and A20. Better preservation of liver function was found in the treatment group. Hepatic ultrastructure, especially the integrity of sinusoids, was well protected in the treatment group. In conclusion, low-dose somatostatin rescues small-for-size grafts from acute phase injury in liver transplantation by attenuation of acute-phase shear stress that resulted from transient portal hypertension.\n                      <jats:bold>Liver Transpl 12:621\u2013627, 2006.<\/jats:bold>\n                      <jats:bold>\u00a9 2006 AASLD.<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lt.20630","type":"journal-article","created":{"date-parts":[[2006,3,22]],"date-time":"2006-03-22T19:16:37Z","timestamp":1143054997000},"page":"621-627","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":80,"title":["Attenuation of acute phase shear stress by somatostatin improves small-for-size liver graft survival"],"prefix":"10.1097","volume":"12","author":[{"given":"Xiao","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwan","family":"Man","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu Sen","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting Bo","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence K.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin T.","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheung Tat","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung Mau","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20-20250124","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1001\/archsurg.136.3.280","article-title":"Liver transplantation in rats using smallforsize grafts: A study of hemodynamic and morphological changes.","volume":"136","author":"Man","year":"2001","journal-title":"Arch Surg"},{"key":"R2-20-20250124","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1053\/jlts.2003.50066","article-title":"Intragraft gene expression profiles by cDNA microarray in smallforsize liver grafts.","volume":"9","author":"Man","year":"2003","journal-title":"Liver Transpl"},{"key":"R3-20-20250124","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1097\/01.TP.0000048490.24429.89","article-title":"Distinct intragraft response pattern in relation to graft size in liver transplantation.","volume":"75","author":"Liang","year":"2003","journal-title":"Transplantation"},{"key":"R4-20-20250124","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/01.sla.0000129673.13552.c0","article-title":"FK 409 ameliorates smallforsize liver graft injury by attenuation of portal hypertension and downregulation of Egr1 pathway.","volume":"240","author":"Man","year":"2004","journal-title":"Ann Surg"},{"key":"R5-20-20250124","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1111\/j.1600-6143.2004.00527.x","article-title":"Attenuation of smallforsize liver graft injury by FTY720: Significance of cellsurvival Akt signaling pathway.","volume":"4","author":"Zhao","year":"2004","journal-title":"Am J Transplant"},{"key":"R6-20-20250124","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1097\/01.SLA.0000048976.11824.67","article-title":"Graft injury in relation to graft size in right lobe live donor liver transplantation: A study of hepatic sinusoidal injury in correlation with portal hemodynamics and intragraft gene expression.","volume":"237","author":"Man","year":"2003","journal-title":"Ann Surg"},{"key":"R7-20-20250124","first-page":"G624","article-title":"Endothelin1 induces direct constriction of hepatic sinusoids.","volume":"266","author":"Zhang","year":"1994","journal-title":"Am J Physiol"},{"key":"R8-20-20250124","first-page":"106","article-title":"Effects of bolus injections and continuous infusions of somatostatin and placebo in patients with cirrhosis: A doubleblind hemodynamic investigation.","volume":"22","author":"Cirera","year":"1995","journal-title":"Hepatology"},{"key":"R9-20-20250124","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/0016-5085(81)90014-7","article-title":"Effects of somatostatin on hepatic and systemic hemodynamics in patients with cirrhosis of the liver: Comparison with vasopressin.","volume":"80","author":"Bosch","year":"1981","journal-title":"Gastroenterology"},{"key":"R10-20-20250124","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/0016-5085(81)90015-9","article-title":"Effect of somatostatin on splanchnic hemodynamics in patients with cirrhosis of the liver and in normal subjects.","volume":"80","author":"Sonnenberg","year":"1981","journal-title":"Gastroenterology"},{"key":"R11-20-20250124","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1046\/j.1365-2036.2001.00996.x","article-title":"Bolus somatostatin but not octreotide reduces hepatic sinusoidal pressure by a NOindependent mechanism in chronic liver disease.","volume":"15","author":"Matrella","year":"2001","journal-title":"Aliment Pharmacol Ther"},{"key":"R12-20-20250124","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/S0002-9610(05)80786-X","article-title":"Somatostatin attenuates ischemic intestinal injury.","volume":"165","author":"Morris","year":"1993","journal-title":"Am J Surg"},{"key":"R13-20-20250124","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1016\/S0041-1345(99)00505-9","article-title":"Prevention by somatostatine and Nacetylcisteine of multiorgan failure mediated by oxidative stress after intestinal ischemia.","volume":"31","author":"Ferrer","year":"1999","journal-title":"Transplant Proc"},{"key":"R14-20-20250124","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1053\/gast.2001.27971","article-title":"Somatostatin suppresses endothelin1induced rat hepatic stellate cell contraction via somatostatin receptor subtype 1.","volume":"121","author":"Reynaert","year":"2001","journal-title":"Gastroenterology"},{"key":"R15-20-20250124","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1053\/jlts.2003.50081","article-title":"Portal hyperperfusion injury as the cause of primary nonfunction in a smallforsize liver graftsuccessful treatment with splenic 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injury.","volume":"74","author":"Coito","year":"2002","journal-title":"Transplantation"},{"key":"R22-20-20250124","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1172\/JCI10613","article-title":"Inducible nitric oxide synthase is critical for immunemediated liver injury in mice.","volume":"107","author":"Sass","year":"2001","journal-title":"J Clin Invest"},{"key":"R23-20-20250124","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1053\/jhep.2002.31309","article-title":"A20 protects mice from Dgalactosaminelipopolysaccharide acute toxic lethal hepatitis.","volume":"35","author":"Arvelo","year":"2002","journal-title":"Hepatology"},{"key":"R24-20-20250124","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1002\/hep.510270626","article-title":"Apoptosis of sinusoidal endothelial cells is a critical mechanism of preservation injury in rat liver 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