{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:09:05Z","timestamp":1787792945243,"version":"build-2784847793"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":3379,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>The shortage of cadaveric donor organs has led to the use of living donors and marginal cadaveric donors. To date, there have been only 2 reports on the use of hepatitis B surface antigen (HBsAg)-positive liver grafts. Here we describe the 5-yr posttransplantation sequence of a hepatitis B virus (HBV)-positive recipient who received an HBsAg-positive living donor liver graft. A 43-yr-old HBV-positive patient with hepatorenal syndrome received a living donor liver graft in October 2000 from a 27-yr-old HBsAg-positive carrier with no clinical evidence of HBV infection other than the serologic markers. The recipient recovered slowly after liver transplantation (LT). Recipient serum HBsAg was continuously positive despite anti-HBV therapy with high-dose hepatitis B immunoglobulin (HBIG) and lamivudine. The patient was also treated with famciclovir and interferon; to date, a final regimen of lamivudine and adefovir has kept liver function stable for 20 months. The recipient has lived for 64 months after transplantation. The donor has not revealed any clinical evidence of active hepatitis during follow-up. In conclusion, our result implicates that a recipient of liver graft from an HBsAg-positive carrier may survive for a long period following antiviral therapy with lamivudine and adefovir. Considering this living donor case and previously reported cases, the use of an HBsAg-positive cadaveric liver graft may deserve attention when no other donor is available. <jats:bold>\n                                    Liver Transpl 12:993\u2013997, 2006.\n                                 <\/jats:bold>\n                                 <jats:bold>\u00a9 2006 AASLD.<\/jats:bold>\n                              <\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/lt.20799","type":"journal-article","created":{"date-parts":[[2006,5,23]],"date-time":"2006-05-23T18:59:14Z","timestamp":1148410754000},"page":"993-997","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":31,"title":["Five-year follow-up of a hepatitis B virus-positive recipient of hepatitis B surface antigen-positive living donor liver graft"],"prefix":"10.1097","volume":"12","author":[{"given":"Shin","family":"Hwang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Gyu","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang-Min","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki-Hun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul-Soo","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heung-Bum","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deok-Bog","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Yong","family":"Ha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Suk","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Hwan","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-18-20250124","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1097\/00007890-200006150-00034","article-title":"Selection and outcome of living donors for adult to adult right lobe transplantation.","volume":"69","author":"Marcos","year":"2000","journal-title":"Transplantation"},{"key":"R2-18-20250124","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1097\/01.TP.0000046535.49186.EB","article-title":"Evaluation of living liver donors.","volume":"75","author":"Chen","year":"2003","journal-title":"Transplantation"},{"key":"R3-18-20250124","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/lt.20179","article-title":"Advances in adult living donor liver transplantation: a review based on reports from the 10th anniversary of the adulttoadult living donor liver transplantation meeting in Tokyo.","volume":"10","author":"Sugawara","year":"2004","journal-title":"Liver Transpl"},{"key":"R4-18-20250124","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/00007890-199407000-00023","article-title":"Transplantation of a hepatitis B surface antigenpositive donor liver into a hepatitis B virusnegative recipient.","volume":"58","author":"GonzalezPeralta","year":"1994","journal-title":"Transplantation"},{"key":"R5-18-20250124","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1002\/lt.20471","article-title":"Transplantation of hepatitis B surface antigenpositive livers into hepatitis B viruspositive recipients and the role of hepatitis delta coinfection.","volume":"11","author":"Franchello","year":"2005","journal-title":"Liver Transpl"},{"key":"R6-18-20250124","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1002\/lt.20449","article-title":"The use of HBsAgpositive organ donors: far more than meets the eye?","volume":"11","author":"Perrillo","year":"2005","journal-title":"Liver Transpl"},{"key":"R7-18-20250124","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1002\/lt.20734","article-title":"Lessons learned from 1000 living donor liver transplantations in a single center: how to make living donations safe.","volume":"12","author":"Hwang","year":"2006","journal-title":"Liver Transpl"},{"key":"R8-18-20250124","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/0016-5085(87)90427-6","article-title":"Frequency and significance of concurrent hepatitis B surface antigen and antibody in acute and chronic hepatitis B.","volume":"93","author":"Shiels","year":"1987","journal-title":"Gastroenterology"},{"key":"R9-18-20250124","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1007\/s005350050379","article-title":"Detection of preSS gene mutants in chronic hepatitis B carriers with concurrent hepatitis B surface antibody and hepatitis B surface antigen.","volume":"34","author":"Wang","year":"1999","journal-title":"J Gastroenterol"},{"key":"R10-18-20250124","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1053\/jhep.2001.29401","article-title":"Chronic hepatitis B.","volume":"34","author":"Lok","year":"2001","journal-title":"Hepatology"},{"key":"R11-18-20250124","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/hep.20110","article-title":"Chronic hepatitis B: update of recommendations.","volume":"39","author":"Lok","year":"2004","journal-title":"Hepatology"},{"key":"R13-18-20250124","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S1015-9584(09)60192-5","article-title":"Adulttoadult living donor liver transplantation at the Asan Medical Center, Korea.","volume":"25","author":"Lee","year":"2002","journal-title":"Asian J Surg"},{"key":"R14-18-20250124","doi-asserted-by":"crossref","first-page":"S45S48","DOI":"10.1097\/01.TP.0000047030.38665.0D","article-title":"Safety of antihepatitis B core antibodypositive donors for livingdonor liver 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Transpl"},{"key":"R18-18-20250124","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/lt.20416","article-title":"Liver transplantation for chronic hepatitis B with lamivudineresistant YMDD mutant using addon adefovir dipivoxil plus lamivudine.","volume":"11","author":"Lo","year":"2005","journal-title":"Liver Transpl"},{"key":"R19-18-20250124","doi-asserted-by":"crossref","first-page":"489","DOI":"10.3346\/jkms.2004.19.4.489","article-title":"Current antiviral therapy for chronic hepatitis B.","volume":"19","author":"Lim","year":"2004","journal-title":"J Korean Med Sci"},{"key":"R20-18-20250124","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1007\/BF01318693","article-title":"Clinical significance of concurrent hepatitis B surface antigen and antibody positivity.","volume":"31","author":"Tsang","year":"1986","journal-title":"Dig Dis 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