{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:09:41Z","timestamp":1761487781325,"version":"3.33.0"},"reference-count":51,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":3106,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:sec>\n            <jats:title>Abstract<\/jats:title>\n            <jats:p>The purpose of the study was to determine the incidence, risk factors, treatment, and influence on survival of patients with de novo esophageal cancer after liver transplantation (LT). From 1988 to 2006, 1,926 patients underwent LT in our institution. A total of 9 patients (0.5%) developed a de novo esophageal cancer and 1 patient a cancer of the cardia (0.05%). A retrospective analysis was performed to reveal underlying diseases, timeframes between LT and appearance of cancer, predisposing factors, cancer therapy, complications, immunosuppressive regimens, and survival. Of our 10 patients, 7 (70%) suffered from esophageal squamous cell carcinoma (SCC) and 3 patients (30%) developed an adenocarcinoma, including the patient with cancer of the cardia. A total of 9 patients were transplanted due to alcoholic cirrhosis; 1 patient suffered from hepatocellular carcinoma in nonA-nonB hepatitis-related cirrhosis. Median time to tumor diagnosis was 51 months after transplantation. A total of 5 patients were treated conservatively with combined radiochemotherapy and 5 underwent surgical resection. Patients with radiochemotherapy showed a mean survival of 14.8 months vs. 24.8 months for the patients of the surgery group. No major postoperative complication has been observed. A total of 2 patients of the surgery group are still alive after a follow-up of 15 and 89 months. In conclusion, de novo esophageal and cancer of the cardia after LT is a rare event. In spite of immunosuppression, no increased complication rate has been observed. Patients may have a survival benefit from surgical resection. <jats:italic toggle=\"yes\">Liver Transpl 13:443\u2013450, 2007.<\/jats:italic> \u00a9 2007 AASLD.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/lt.21058","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T23:08:15Z","timestamp":1172185695000},"page":"443-450","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":28,"title":["De Novo Esophageal Neoplasia After Liver Transplantation"],"prefix":"10.1097","volume":"13","author":[{"given":"Sabine J.","family":"Presser","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Schumacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Neuhaus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Thuss-Patience","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Stieler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Neuhaus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-20-20250124","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1097\/01.TP.0000092955.28529.1E","article-title":"Quality of life in adult survivors beyond 10 years after liver, kidney, and heart transplantation.","volume":"76","author":"Karam","year":"2003","journal-title":"Transplantation"},{"key":"R2-20-20250124","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1097\/00007890-200003150-00018","article-title":"Longterm medical complications in patients surviving or 5 years after liver transplant.","volume":"69","author":"Sheiner","year":"2000","journal-title":"Transplantation"},{"key":"R3-20-20250124","doi-asserted-by":"crossref","first-page":"S109","DOI":"10.1053\/jlts.2001.28645","article-title":"De novo malignancies after liver transplantation: a major cause of late death.","volume":"7","author":"Fung","year":"2001","journal-title":"Liver Transpl"},{"key":"R4-20-20250124","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/lt.20128","article-title":"Recurrence of hepatocellular carcinoma after liver transplant: patterns and prognosis.","volume":"10","author":"Roayaie","year":"2004","journal-title":"Liver 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