{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T16:54:32Z","timestamp":1772470472668,"version":"3.50.1"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":3014,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      Hepatorenal syndrome (HRS) is a well-recognized complication of end-stage liver disease. Once thought to be a reversible condition with liver transplantation (LT) alone, HRS may directly contribute to the requirement for long-term dialysis posttransplant. As a result, discussion has now focused on whether or when a kidney allograft should be considered for these patients. Using the International Ascites Club guidelines with a pretransplant serum creatinine (SCr) &gt;2.0 mg\/dL to define HRS, 130 patients undergoing LT over a 10-yr period were identified, for an overall incidence of 9%. Patient survival rates at 1, 3, and 5 yr were 74%, and 68%, and 62%, respectively. Survival was significantly worse when compared to non-HRS patients undergoing LT over the same study period (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0001). For patients presenting with type 2 HRS, 7 patients (6%) developed irreversible kidney failure posttransplant compared to 0.34% in the non-HRS population (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001). Five of these patients died within 1 yr with a median survival time of 139 days. Combined liver and kidney transplantation (CLKT) for patients with HRS is not recommended. However, an improvement in outcome can be accomplished by addressing those patients who require dialysis greater than 60 days posttransplant. We propose a role for kidney after liver transplantation (KALT) in select HRS patients.\n                      <jats:italic toggle=\"yes\">Liver Transpl 13:838\u2013843, 2007.<\/jats:italic>\n                      \u00a9 2007 AASLD.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lt.21149","type":"journal-article","created":{"date-parts":[[2007,5,30]],"date-time":"2007-05-30T16:47:22Z","timestamp":1180543642000},"page":"838-843","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":76,"title":["Hepatorenal Syndrome"],"prefix":"10.1097","volume":"13","author":[{"given":"Richard","family":"Ruiz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yousri M.","family":"Barri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda W.","family":"Jennings","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srinath","family":"Chinnakotla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M.","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlon F.","family":"Levy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greg J.","family":"McKenna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry B.","family":"Randall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmund Q.","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goran B.","family":"Klintmalm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-11-20260302","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1002\/hep.20687","article-title":"MELD score and clinical type predict prognosis in hepatorenal syndrome: relevance to liver transplantation.","volume":"41","author":"Alessandria","year":"2005","journal-title":"Hepatology"},{"key":"R2-11-20260302","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0016-5085(93)90031-7","article-title":"Incidence, predictive factors, and prognosis of the hepatorenal syndrome in cirrhosis with ascites.","volume":"105","author":"Gines","year":"1993","journal-title":"Gastroenterology"},{"key":"R3-11-20260302","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1097\/00007890-199502150-00010","article-title":"Impact of pretransplant renal function on survival after liver transplantation.","volume":"59","author":"Gonwa","year":"1995","journal-title":"Transplantation"},{"key":"R5-11-20260302","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1097\/00007890-199712270-00024","article-title":"Hepatorenal syndrome: combined liver kidney transplants versus isolated liver transplant.","volume":"64","author":"Jeyarajah","year":"1997","journal-title":"Transplantation"},{"key":"R6-11-20260302","first-page":"164","article-title":"Definition and diagnostic criteria of refractory ascites and hepatorenal syndrome in cirrhosis. International Ascites Club.","volume":"23","author":"Arroyo","year":"1996","journal-title":"Hepatology"},{"key":"R7-11-20260302","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1001\/archsurg.141.8.735","article-title":"Longterm analysis of combined liver and kidney transplantation at a single center.","volume":"141","author":"Ruiz","year":"2006","journal-title":"Arch Surg"},{"key":"R8-11-20260302","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.transproceed.2006.01.074","article-title":"Acute renal failure after liver transplantation: Incidence, etiology, therapy, and outcome.","volume":"38","author":"Junge","year":"2006","journal-title":"Transplant Proc"},{"key":"R9-11-20260302","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1016\/j.transproceed.2004.07.002","article-title":"Acute renal failure after cadaveric related liver transplantation.","volume":"36","author":"Chuang","year":"2004","journal-title":"Transplant Proc"},{"key":"R10-11-20260302","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1097\/00007890-199102000-00030","article-title":"Longterm survival and renal function following liver transplantation in patients with and without hepatorenal syndrome-experience in 300 patients.","volume":"51","author":"Gonwa","year":"1991","journal-title":"Transplantation"},{"key":"R11-11-20260302","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1053\/jlts.2002.32504","article-title":"Identification of patients best suited for combined liverkidney transplantation: Part II.","volume":"8","author":"Davis","year":"2002","journal-title":"Liver Transpl"},{"key":"R12-11-20260302","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1046\/j.1399-0012.2003.00132.x","article-title":"Postliver transplant acute renal failure: factors predicting development of endstage renal disease.","volume":"18","author":"Paramesh","year":"2004","journal-title":"Clin Transplant"},{"key":"R13-11-20260302","first-page":"329","article-title":"Results of combined and sequential liverkidney transplantation. Liver Transpl 2003; 9: 1067-1078.","volume":"10","author":"Demirci","year":"2004","journal-title":"Erratum in: Liver Transpl"}],"container-title":["Liver Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flt.21149","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01445473-200706000-00011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T16:00:52Z","timestamp":1772467252000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01445473-200706000-00011"}},"subtitle":["A Proposal for Kidney After Liver Transplantation (KALT)"],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007]]}},"URL":"https:\/\/doi.org\/10.1002\/lt.21149","relation":{},"ISSN":["1527-6465"],"issn-type":[{"value":"1527-6465","type":"print"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}