{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:50:10Z","timestamp":1786978210156,"version":"build-2736575974"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":2984,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      Liver transplantation (LT) has been reported in only 1 patient with hereditary variant apolipoprotein AI (apoAI) amyloidosis and was associated with a 50% decrease in production of variant apoAI. The potential for this to benefit clinical manifestations of apoAI amyloidosis such as peripheral neuropathy has not been determined. A 59-yr-old Irish-born male with hereditary systemic amyloidosis associated with apoAI Gly26Arg, which was suspected to be the cause of a progressive peripheral neuropathy, along with end-stage renal failure and hepatic dysfunction, underwent hepatorenal transplantation. Evaluation of his clinical outcome included serial neurological examinations and nerve conduction studies. The proportion of variant apoAI in the plasma was estimated before and after LT. Hepatorenal transplantation was successful, with the plasma concentration of variant apoAI decreasing by over 50% after transplantation and this was associated with progressive resolution of the patient's neuropathic symptoms and a significant and sustained improvement in electrophysiological parameters. In conclusion, liver transplantation reduces production of the amyloid fibril precursor protein to a degree that can facilitate net regression of amyloid deposits, which may aid recovery of end-organ damage such as that seen in peripheral neuropathy.\n                      <jats:italic toggle=\"yes\">Liver Transpl 13:1028\u20131031, 2007.<\/jats:italic>\n                      \u00a9 2007 AASLD.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lt.21176","type":"journal-article","created":{"date-parts":[[2007,6,28]],"date-time":"2007-06-28T14:47:47Z","timestamp":1183042067000},"page":"1028-1031","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":22,"title":["Hereditary Amyloidosis with Progressive Peripheral Neuropathy Associated with Apolipoprotein AI Gly26Arg"],"prefix":"10.1097","volume":"13","author":[{"given":"Adam G.","family":"Testro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen O.","family":"Brennan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.L.","family":"Macdonell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip N.","family":"Hawkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter W.","family":"Angus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-15-20250124","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1042\/bst0210493","article-title":"Synthesis and secretion of apolipoprotein AI.","volume":"21","author":"Calandra","year":"1993","journal-title":"Biochem Soc Trans"},{"key":"R2-15-20250124","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1097\/00007890-200104150-00026","article-title":"Clinical and biochemical outcome of hepatorenal transplantation for hereditary systemic amyloidosis associates with apolipoprotein A1 Gly26Arg.","volume":"71","author":"Gillmore","year":"2001","journal-title":"Transplantation"},{"key":"R4-15-20250124","first-page":"149","article-title":"Familial nephropathic systemic amyloidosis caused by apolipoprotein AI variant Gly26Arg.","volume":"87","author":"Vigushin","year":"1994","journal-title":"QJM"},{"key":"R5-15-20250124","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1042\/cs090033P","article-title":"A new deletion mutation of the apolipoprotein AI gene causing hereditary amyloidosis.","volume":"90","author":"Persey","year":"1996","journal-title":"Clin Sci"},{"key":"R6-15-20250124","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/0888-7543(90)90288-6","article-title":"A mutation in apolipoprotein AI in the Iowa type of familial amyloidotic polyneuropathy.","volume":"8","author":"Nichols","year":"1990","journal-title":"Genomics"},{"key":"R7-15-20250124","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1053\/jhep.2002.35063","article-title":"Novel fibrinogen 375 ArgTrp mutation (fibrinogen aguadilla) causes hepatic endoplasmic reticulum storage and hypofibrinogenaemia.","volume":"36","author":"Brennan","year":"2002","journal-title":"Hepatology"},{"key":"R8-15-20250124","doi-asserted-by":"crossref","first-page":"143","DOI":"10.7326\/0003-4819-109-2-143","article-title":"Nervous system complications of uremia.","volume":"109","author":"Fraser","year":"1988","journal-title":"Ann Intern Med"},{"key":"R9-15-20250124","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1212\/WNL.19.1.10","article-title":"Inherited predisposition to generalized amyloidosis. Clinical and pathological study of a family with neuropathy, nephropathy, and peptic ulcer. Neurology 1969; 19: 10-25. 323.sition to generalized amyloidosis. Clinical and pathological study of a family with neuropathy, nephropathy, and peptic ulcer.","volume":"19","author":"Van Allen","year":"1969","journal-title":"Neurology"}],"container-title":["Liver Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flt.21176","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01445473-200707000-00015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T11:14:27Z","timestamp":1737717267000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01445473-200707000-00015"}},"subtitle":["Outcome of Hepatorenal Transplantation"],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":8,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2007]]}},"URL":"https:\/\/doi.org\/10.1002\/lt.21176","relation":{},"ISSN":["1527-6465"],"issn-type":[{"value":"1527-6465","type":"print"}],"subject":[],"published":{"date-parts":[[2007,7]]}}}