{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T18:57:30Z","timestamp":1778871450889,"version":"3.51.4"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":2892,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>Human leukocyte antigen (HLA) compatibility has no clinically significant impact in cadaveric liver transplantation. Less is known regarding living-donor liver transplantation (LDLT). Our prior analysis of the Organ Procurement and Transplantation Network (OPTN) database suggested a higher graft failure rate in patients who underwent LDLT from donors with close HLA match. We further investigated the effect of HLA-A, -B, and -DR matching on 5-yr graft survival in adult LDLT by analyzing OPTN data regarding adult LDLT performed between 1998 and 2005. We evaluated associations between 5-yr graft survival and total, locus-specific, and haplotype match levels. Separate analyses were conducted for recipients with autoimmune (fulminant autoimmune hepatitis, cirrhosis secondary to autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis) or nonautoimmune liver disease. Multivariable Cox proportional hazard models were used to evaluate interactions and adjust for potential confounders. Among 631 patients with available donor\/recipient HLA data, the degree of HLA match had no significant effect on 5-yr graft survival, even when analyzed separately in recipients with autoimmune vs. nonautoimmune liver disease. To be able to include all 1,838 adult LDLTs, we considered a first-degree related donor as substitute for a close HLA match. We found no difference in graft survival in related vs. unrelated pairs. In conclusion, our results show no detrimental impact of close HLA matching on graft survival in adult LDLT, including in recipients with underlying autoimmune liver disease. <jats:italic toggle=\"yes\">Liver Transpl 13:1405\u20131413, 2007.<\/jats:italic> \u00a9 2007 AASLD.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/lt.21264","type":"journal-article","created":{"date-parts":[[2007,9,27]],"date-time":"2007-09-27T16:46:51Z","timestamp":1190911611000},"page":"1405-1413","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":25,"title":["Human Leukocyte Antigen and Adult Living-Donor Liver Transplantation Outcomes"],"prefix":"10.1097","volume":"13","author":[{"given":"Simona S.","family":"Jakab","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor J.","family":"Navarro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beth W.","family":"Colombe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantine","family":"Daskalakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven K.","family":"Herrine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-11-20250124","first-page":"705","article-title":"The antibody crossmatch in liver transplantation.","volume":"100","author":"Gordon","year":"1986","journal-title":"Surgery"},{"key":"R2-11-20250124","first-page":"372","article-title":"Histocompatibility and Liver Transplant Outcome: Does HLA exert a dualistic effect?","volume":"46","author":"Markus","year":"1988","journal-title":"Transplantation"},{"key":"R3-11-20250124","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1002\/hep.1840170611","article-title":"Influence of human leucocytes antigen matching on liver allograft survival and rejection: the dualistic effect.","volume":"17","author":"Donaldson","year":"1993","journal-title":"Hepatology"},{"key":"R4-11-20250124","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/00007890-200301150-00024","article-title":"Impact of Human Leukocyte Antigen Matching in Liver Transplantation.","volume":"75","author":"Neumann","year":"2003","journal-title":"Transplantation"},{"key":"R5-11-20250124","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1002\/lt.20680","article-title":"The effect of HLA class I (A and B) and class II (DR) compatibility on liver transplantation outcomes: an analysis of the OPTN database.","volume":"12","author":"Navarro","year":"2006","journal-title":"Liver Transpl"},{"key":"R6-11-20250124","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1097\/00007890-199305000-00024","article-title":"The influence of HLA matching on cytomegalovirus hepatitis and chronic rejection after liver transplantation.","volume":"55","author":"Manez","year":"1993","journal-title":"Transplantation"},{"key":"R7-11-20250124","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1053\/jhep.2000.7879","article-title":"Influence of immunogenetic background on the outcome of recurrent hepatitis C after liver transplantation.","volume":"31","author":"Belli","year":"2000","journal-title":"Hepatology"},{"key":"R8-11-20250124","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1016\/S0041-1345(00)01591-8","article-title":"Impact of HLA matching in livingrelated liver transplantation.","volume":"32","author":"Hirata","year":"2000","journal-title":"Transplant Proc"},{"key":"RU9-11-20250124","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1016\/S0041-1345(00)01590-6","article-title":"Influence of HLA compatibility on livingrelated liver transplantation.","volume":"32","author":"Harihara","year":"2000","journal-title":"Transplant Proc"},{"key":"RU10-11-20250124","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1097\/00007890-200210270-00020","article-title":"Role of HLA compatibility in pediatric livingrelated liver transplantation.","volume":"74","author":"Kasahara","year":"2002","journal-title":"Transplantation"},{"key":"R11-11-20250124","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1034\/j.1399-0012.2003.00057.x","article-title":"Risk factors for acute rejection in living donor liver transplantation.","volume":"17","author":"Sugawara","year":"2003","journal-title":"Clin Transplant"},{"key":"R12-11-20250124","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1111\/j.1478-3231.2005.01160.x","article-title":"Influence of HLA compatibility and lymphocyte crossmatching on acute cellular rejection following living donor adult liver transplantation.","volume":"25","author":"Suehiro","year":"2005","journal-title":"Liver Int"},{"key":"R13-11-20250124","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/lt.20856","article-title":"Impact of human leukocyte antigen mismatching on outcomes of living donor liver transplantation for primary biliary cirrhosis.","volume":"13","author":"Morioka","year":"2007","journal-title":"Liver Transpl"}],"container-title":["Liver 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Database\u2020"],"short-title":[],"issued":{"date-parts":[[2007,10]]},"references-count":13,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2007]]}},"URL":"https:\/\/doi.org\/10.1002\/lt.21264","relation":{},"ISSN":["1527-6465"],"issn-type":[{"value":"1527-6465","type":"print"}],"subject":[],"published":{"date-parts":[[2007,10]]}}}