{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:07:45Z","timestamp":1786118865025,"version":"build-2736575974"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":2709,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      <jats:bold>Living donor liver transplantation has acquired widespread acceptance. A thorough workup of the potential living donor is guided by 2 objectives: the first is ensuring the safety of the surgical procedure for the donor, and the second is identifying donor grafts that pose potential risks for the recipient. Of 305 living-related liver donors, liver biopsy was performed in 201. The results of those patients' liver function tests and serologic tests were within normal limits. Forty-one of the 201 patients had steatosis on abdominal ultrasonography or tomography. Of 201 liver biopsies, 94 (46.8%) demonstrated normal findings, whereas 107 (53.2%) showed abnormal findings on pathology. Of 107 patients with abnormal pathological findings, 32 (29.9%) had fatty changes, 4 (3.7%) had steatohepatitis, and 71 (66.4%) had nonsteatotic histologic findings including fibrosis, hepatitis, and granulomatous reactions. In conclusion, our data show that half of the living-related liver donors, appearing absolutely healthy, had biopsies with abnormal pathology results. As it is well known that increasing percentages of steatosis may reduce the functional mass of the graft and occult liver diseases may not be detected without liver biopsy, we recommend that liver biopsies be part of the routine evaluation protocol for living-related liver donors in all transplantation institutions.<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lt.21410","type":"journal-article","created":{"date-parts":[[2008,3,26]],"date-time":"2008-03-26T13:46:59Z","timestamp":1206539219000},"page":"541-546","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":22,"title":["Value of An Individual Liver Biopsy in the Preoperative Evaluation of Apparently Healthy Potential Liver Donors"],"prefix":"10.1097","volume":"14","author":[{"given":"Nurten","family":"Savas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Coskun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banu","family":"Bilezikci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irfan","family":"Uruc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamdi","family":"Karakayali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ugur","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Haberal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-21-20250326","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1056\/NEJMsa021345","article-title":"A survey of liver transplantation from living adult donors in the United States.","volume":"348","author":"Brown","year":"2003","journal-title":"N Engl J Med"},{"key":"R2-21-20250326","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1148\/radiol.2301021176","article-title":"Macrovesicular hepatic steatosis in living related liver donors: correlation between CT and histologic findings.","volume":"230","author":"Limanond","year":"2004","journal-title":"Radiology"},{"issue":"pt 1","key":"R3-21-20250326","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/hep.1840200410","article-title":"Selecting the donor liver: risk factors for poor function after orthotopic liver transplantation. review.","volume":"20","author":"Strasberg","year":"1994","journal-title":"Hepatology"},{"key":"R4-21-20250326","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1097\/01.TP.0000140499.23683.0D","article-title":"Noninvasive evaluation of graft steatosis in living donor liver transplantation.","volume":"78","author":"Iwasaki","year":"2004","journal-title":"Transplantation"},{"key":"R5-21-20250326","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1002\/lt.20462","article-title":"Preoperative donor liver biopsy for adult living donor liver transplantation: risks and benefits.","volume":"11","author":"Nadalin","year":"2005","journal-title":"Liver Transpl"},{"key":"R6-21-20250326","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1097\/00007890-199611150-00011","article-title":"Use of fatty donor liver is associated with diminished early patient and graft survival.","volume":"62","author":"Marsman","year":"1996","journal-title":"Transplantation"},{"key":"R7-21-20250326","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1053\/hupa.2000.18473","article-title":"Steatosis in donor and transplant liver biopsies. review.","volume":"31","author":"Crowley","year":"2000","journal-title":"Hum Pathol"},{"key":"R8-21-20250326","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1097\/00007890-200006150-00034","article-title":"Selection and outcome of living donors for adult to adult right lobe transplantation.","volume":"69","author":"Marcos","year":"2000","journal-title":"Transplantation"},{"key":"R9-21-20250326","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/0140-6736(92)92559-X","article-title":"Effect of extended cold ischemia with UW solution on graft function after liver transplantation.","volume":"340","author":"Adam","year":"1992","journal-title":"Lancet"},{"key":"R10-21-20250326","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1053\/jlts.2003.50099","article-title":"Clinical experience gained from the use of 120 steatotic donor livers for orthotopic liver transplantation.","volume":"9","author":"Verran","year":"2003","journal-title":"Liver Transpl"},{"key":"R11-21-20250326","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1097\/00007890-199304000-00024","article-title":"Risk factors for primary dysfunction after liver transplantationa multivariate analysis.","volume":"55","author":"Ploeg","year":"1993","journal-title":"Transplantation"},{"key":"R12-21-20250326","first-page":"2605","article-title":"Is needle biopsy mandatory for donor selection in live donor segmental liver transplantation?","volume":"27","author":"Haberal","year":"1995","journal-title":"Transplant Proc"},{"key":"R13-21-20250326","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1097\/00007890-199901270-00024","article-title":"Impact of graft size mismatching on graft prognosis in liver transplantation from living donors.","volume":"67","author":"Kiuchi","year":"1999","journal-title":"Transplantation"},{"issue":"suppl 2","key":"R14-21-20250326","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.1053\/jlts.2000.19011","article-title":"Rightlobe living donor liver transplantation.","volume":"6","author":"Marcos","year":"2000","journal-title":"Liver Transpl"},{"key":"R15-21-20250326","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/00007890-199901270-00002","article-title":"The mechanism of injury in a steatotic liver graft during cold preservation.","volume":"67","author":"Fukumori","year":"1999","journal-title":"Transplantation"},{"key":"R16-21-20250326","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/lt.500040110","article-title":"In vivo demonstration of impaired microcirculation in steatotic human liver grafts.","volume":"4","author":"Seifalian","year":"1998","journal-title":"Liver Transpl Surg"},{"key":"R17-21-20250326","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1053\/jlts.2001.23787","article-title":"Body mass index as a predictor of hepatic steatosis in living liver donors.","volume":"7","author":"Rinella","year":"2001","journal-title":"Liver Transpl"},{"key":"R18-21-20250326","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.humpath.2003.10.029","article-title":"Assessment of donor liver steatosis: pathologist or automated software?","volume":"35","author":"Marsman","year":"2004","journal-title":"Hum Pathol"},{"key":"R19-21-20250326","doi-asserted-by":"crossref","first-page":"473","DOI":"10.7326\/0003-4819-111-6-473","article-title":"Is liver biopsy useful in the evaluation of patients with chronically elevated liver enzymes?","volume":"111","author":"Van Ness","year":"1989","journal-title":"Ann Intern Med"},{"key":"R20-21-20250326","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1053\/jlts.2002.36740","article-title":"One hundred consecutive hepatic biopsies in the workup of living donors for right lobe liver transplantation.","volume":"8","author":"Ryan","year":"2002","journal-title":"Liver Transpl"},{"key":"R21-21-20250326","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1148\/radiol.2391050361","article-title":"Macrovesicular hepatic steatosis in living liver donors: use of CT for quantitative and qualitative assessment.","volume":"239","author":"Park","year":"2006","journal-title":"Radiology"},{"key":"R22-21-20250326","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1053\/jlts.2002.36492","article-title":"The optimal number of donor biopsy sites to evaluate liver histology for transplantation.","volume":"8","author":"Frankel","year":"2002","journal-title":"Liver Transpl"},{"key":"R23-21-20250326","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1440-1746.2005.03968.x","article-title":"Living donor liver transplantation: histological abnormalities found on liver biopsies of apparently healthy potential donors.","volume":"21","author":"Tran","year":"2006","journal-title":"J Gastroenterol Hepatol"}],"container-title":["Liver Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flt.21410","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ovid.com\/01445473-200804000-00021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T16:54:20Z","timestamp":1786035260000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01445473-200804000-00021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.1002\/lt.21410","relation":{},"ISSN":["1527-6465"],"issn-type":[{"value":"1527-6465","type":"print"}],"subject":[],"published":{"date-parts":[[2008,4]]}}}