{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T18:08:32Z","timestamp":1781719712842,"version":"3.54.5"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":2556,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>\n                                 <jats:bold>Extracorporeal albumin dialysis (ECAD) enables the elimination of albumin bound substances and is used as artificial liver support system. Albumin binding function for the benzodiazepine binding site specific marker Dansylsarcosine was estimated in plasma samples of 22 patients with cirrhosis and hyperbilirubinaemia (ECAD: n = 12; control: n = 10) during a period of 30 days in a randomized controlled clinical ECAD trial. Albumin Binding Capacity (ABiC) at baseline was reduced to 31.8% (median; range 24%-74%) and correlated to the severity of liver disease. Within two weeks a significant improvement of ABiC and a reduction of the albumin bound markers bilirubin and bile acids were observed in the ECAD group. During single treatments a significant decrease of albumin bound substances (bilirubin and bile acids) as well as an increase in ABiC was observed. In the control group, baseline ABiC was significantly lower in patients who died during study period (34.2% vs. 41.7%; P &lt; 0.028), whereas no significant differences were observed for CHILD, coagulation factors, albumin, bile acids nor bilirubin. At baseline 13 patients had a severely impaired ABiC (&lt;40%), improvement of ABiC was more frequent in the ECAD group (5\/6) than in the SMT group (2\/7). Reduced albumin binding function is present in decompensated liver failure and is related to severity and 30 day survival. ABiC can be improved by ECAD. The beneficial effect of this treatment may be related to the improvement of albumin binding function more than to the elimination of specific substances. Characterization of albumin function by the ABiC test may help to evaluate different liver support systems and other therapeutic measures.<\/jats:bold>\n                              <\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/lt.21504","type":"journal-article","created":{"date-parts":[[2008,8,28]],"date-time":"2008-08-28T18:18:14Z","timestamp":1219947494000},"page":"1333-1339","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":55,"title":["Improvement of Impaired Albumin Binding Capacity in Acute-on-Chronic Liver Failure by Albumin Dialysis"],"prefix":"10.1097","volume":"14","author":[{"given":"Sebastian","family":"Klammt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen R.","family":"Mitzner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Stange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Loock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Heemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Emmrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emil C.","family":"Reisinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-17-20250326","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1002\/hep.20720","article-title":"Albumin: biochemical properties and therapeutic potential.","volume":"41","author":"Quinlan","year":"2005","journal-title":"Hepatology"},{"key":"R3-17-20250326","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1248\/bpb.25.695","article-title":"Practical aspects of the ligandbinding and enzymatic properties of human serum albumin.","volume":"25","author":"KraghHansen","year":"2002","journal-title":"Biol Pharm Bull"},{"key":"R4-17-20250326","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.jmb.2006.08.056","article-title":"Chain lengthdependent binding of fatty acid anions to human serum albumin studied by sitedirected mutagenesis.","volume":"363","author":"KraghHansen","year":"2006","journal-title":"J Mol Biol"},{"key":"R5-17-20250326","first-page":"1052","article-title":"Further characterization of specific drug binding sites on human serum albumin.","volume":"12","author":"Sudlow","year":"1976","journal-title":"Mol Pharmacol"},{"key":"R6-17-20250326","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/S0026-895X(25)10691-3","article-title":"The characterization of two specific drug binding sites on human serum albumin.","volume":"11","author":"Sudlow","year":"1975","journal-title":"Mol Pharmacol"},{"key":"R7-17-20250326","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/S0026-895X(25)14450-7","article-title":"Structural requirements for drug binding to site II on human serum albumin.","volume":"24","author":"Wanwimolruk","year":"1983","journal-title":"Mol Pharmacol"},{"key":"R8-17-20250326","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0304-4165(95)00023-5","article-title":"Binding of lithocholate and its glucuronide and sulfate by human serum albumin.","volume":"1244","author":"Takikawa","year":"1995","journal-title":"Biochim Biophys Acta"},{"key":"R9-17-20250326","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1016\/0006-2952(78)90049-7","article-title":"Differentiated effects of liver cirrhosis on the albumin binding sites for diazepam, salicylic acid and warfarin.","volume":"27","author":"Kober","year":"1978","journal-title":"Biochem Pharmacol"},{"key":"R10-17-20250326","doi-asserted-by":"crossref","first-page":"399","DOI":"10.2165\/00003088-199937050-00004","article-title":"Effects of liver disease on pharmacokinetics. 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