{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:08:51Z","timestamp":1787069331771,"version":"build-2736575974"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2008,9,29]],"date-time":"2008-09-29T00:00:00Z","timestamp":1222646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Addenbrooke's Transplant Research Fund"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Liver transplantation provides a return to a satisfactory quality of life (QOL) for the majority of patients in the short to medium term (first 5 years), but there is very little information on the QOL in the longer term and the factors influencing it. We therefore undertook a single-center cross-sectional analysis to determine QOL in patients 10 or more years after liver transplantation. All liver transplant recipients who were followed up at the Cambridge Transplant Unit for 10 or more years (transplanted between 1968 and 1994) and resident in the United Kingdom were asked to complete by post the Short Form 36 version 2 and the Ferrans and Powers questionnaires to evaluate their QOL. Univariate and multivariate analysis were performed to assess the relationship between a range of clinical parameters and QOL. One hundred two patients were invited to participate, and 61 (59.8%) responded. Overall, the patients reported a satisfactory QOL. On the Ferrans and Powers questionnaire, the patients had a mean Quality of Life Index score of 24.5. Factors associated with reduced physical functioning were age &gt; 50 years at transplantation, female gender, and recurrence of the primary liver disease. On the Short Form 36 version 2 questionnaire, recipients had reduced physical functioning but normal mental health parameters in comparison with the normal population. Age &gt; 60 years at the time of survey, female gender, and posttransplant complications were associated with reduced physical functioning. In conclusion, patients 10 or more years after liver transplantation generally have a good QOL, although physical functioning is reduced. Addressing issues such as recurrent disease and posttransplant problems such as osteoporosis may help to improve long-term QOL. Liver Transpl 14:1473\u20131479, 2008. \u00a9 2008 AASLD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lt.21561","type":"journal-article","created":{"date-parts":[[2008,9,29]],"date-time":"2008-09-29T11:29:42Z","timestamp":1222687782000},"page":"1473-1479","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":78,"title":["Quality of Life up to 30 years Following Liver Transplantation"],"prefix":"10.1097","volume":"14","author":[{"given":"Rajendra","family":"Desai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neville V.","family":"Jamieson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander E.","family":"Gimson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Watson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Gibbs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Bradley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raaj K.","family":"Praseedom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"pt 2","key":"R1-13-20250326","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1111\/j.1600-6143.2006.01273.x","article-title":"Liver and intestine transplantation in the United States, 19952004.","volume":"6","author":"Shiffman","year":"2006","journal-title":"Am J Transplant"},{"key":"R2-13-20250326","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1053\/jlts.2002.31345","article-title":"Assessing healthrelated quality of life pre and postliver transplantation: a prospective multicenter study.","volume":"8","author":"Ratcliffe","year":"2002","journal-title":"Liver Transpl"},{"key":"R3-13-20250326","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/lt.500030201","article-title":"Changes in quality of life after liver transplantation among adults. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Liver Transplantation Database (LTD).","volume":"3","author":"Belle","year":"1997","journal-title":"Liver Transpl Surg"},{"key":"R6-13-20250326","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1136\/jech.53.1.46","article-title":"Assessment of the SF36 version 2 in the United Kingdom.","volume":"53","author":"Jenkinson","year":"1999","journal-title":"J Epidemiol Community Health"},{"key":"R7-13-20250326","doi-asserted-by":"crossref","first-page":"805","DOI":"10.2337\/diacare.27.3.805","article-title":"NewOnset Diabetes After Transplantation 2003 International Consensus Guidelines: an endocrinologists view.","volume":"27","author":"Davidson","year":"2004","journal-title":"Diabetes Care"},{"key":"R8-13-20250326","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1097\/01.TP.0000149698.79739.EF","article-title":"Post transplantation bone 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