{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:49:59Z","timestamp":1791175799059,"version":"4.1.0"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2009,2,25]],"date-time":"2009-02-25T00:00:00Z","timestamp":1235520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>We report a donor death after right hepatectomy for living donor transplantation due to an undiagnosed myeloma. The 47-year-old donor, who was the 147th case performed in our department, was in excellent health without any abnormalities in the preoperative investigations. Despite an uneventful right hepatectomy without transfusion, the patient developed a partial thrombus of the inferior vena cava with a right proximal pulmonary trunk embolism on postoperative day 6. Subsequently, he developed multiorgan dysfunction leading to a coagulopathy, respiratory distress, and renal failure requiring hemodialysis and mechanical ventilation. This clinical scenario led us to suspect a hematological disorder. Immune electrophoresis showed a monoclonal peak of immunoglobulin G (8.7 g\/L), a myelogram revealed an abnormally high level of dystrophic plasmocytes (more than 7%), and biopsies of salivary glands confirmed the diagnosis of immunoglobulin G kappa myeloma. The patient progressively deteriorated because of simultaneous hemorrhagic and infectious pulmonary complications resulting in septic shock. Despite an adequate combination of antimicrobial therapy and pleural drainage, the donor died on postoperative day 57 from multiple organ failure. This unusual cause of donor death after right hepatectomy reinforces the need for an extensive preoperative assessment. We advocate the addition of urinary protein loss and electrophoresis to the standard donor assessment protocol.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/lt.21685","type":"journal-article","created":{"date-parts":[[2009,2,25]],"date-time":"2009-02-25T20:05:46Z","timestamp":1235592346000},"page":"326-329","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":14,"title":["Living liver donor death related to complications of myeloma"],"prefix":"10.1097","volume":"15","author":[{"given":"Emmanuel","family":"Melloul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Dondero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Paugam-Burtz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lila","family":"Bouadma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Arnulf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Belghiti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-10-20250330","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1097\/01.sla.0000146146.97485.6c","article-title":"Evolution of donor morbidity in living related liver transplantationa single center analysis of 165 cases.","volume":"240","author":"Broering","year":"2004","journal-title":"Ann Surg"},{"key":"R3-10-20250330","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1002\/lt.20875","article-title":"Documented deaths of hepatic lobe donors for living donor liver transplantation.","volume":"12","author":"Trotter","year":"2006","journal-title":"Liver Transpl"},{"key":"R4-10-20250330","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1053\/j.gastro.2008.04.018","article-title":"Donor morbidity after living donation for liver transplantation.","volume":"135","author":"Ghobrial","year":"2008","journal-title":"Gastroenterology"},{"key":"R5-10-20250330","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1097\/01.tp.0000216825.56841.cd","article-title":"A report of the Vancouver Forum on the care of the live organ donor: lung, liver, pancreas, and intestine data and medical guidelines.","volume":"81","author":"Barr","year":"2006","journal-title":"Transplantation"},{"key":"R6-10-20250330","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/lt.21030","article-title":"Threequarters of right liver donors experienced postoperative complications.","volume":"13","author":"Yi","year":"2007","journal-title":"Liver Transpl"},{"key":"R7-10-20250330","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1002\/lt.20227","article-title":"Fulminant and fatal gas gangrene of the stomach in a healthy live liver donor.","volume":"10","author":"Miller","year":"2004","journal-title":"Liver Transpl"},{"issue":"suppl","key":"R8-10-20250330","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1097\/01.TP.0000046534.45645.47","article-title":"Complications and longterm outcome of living liver donors: a survey of 1,508 cases in five Asian centers.","volume":"75","author":"Lo","year":"2003","journal-title":"Transplantation"},{"key":"R9-10-20250330","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1053\/jlts.2001.28443","article-title":"The living donor experience: donor health assessment and outcomes after living donor liver transplantation.","volume":"7","author":"Beavers","year":"2001","journal-title":"Liver Transpl"},{"key":"R10-10-20250330","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0140-6736(03)14230-4","article-title":"Operative morbidity of living liver donors in Japan.","volume":"362","author":"Umeshita","year":"2003","journal-title":"Lancet"},{"key":"R11-10-20250330","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/lt.20663","article-title":"Living donor liver transplantationadult donor outcomes: a systematic review.","volume":"12","author":"Middleton","year":"2006","journal-title":"Liver Transpl"},{"key":"R12-10-20250330","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s00534-005-1017-9","article-title":"A prospective analysis of livingliver donation shows a high rate of adverse events.","volume":"13","author":"Dondero","year":"2006","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"R13-10-20250330","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1200\/JCO.2005.03.2086","article-title":"Early mortality after diagnosis of multiple myeloma: analysis of patients entered onto the United Kingdom Medical Research Council trials between 1980 and 2002. Medical Research Council Adult Leukaemia Working Party.","volume":"23","author":"Augustson","year":"2005","journal-title":"J Clin Oncol"},{"key":"R14-10-20250330","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1056\/NEJMoa053583","article-title":"Thalidomide and haematopoieticcell transplantation for multiple myeloma.","volume":"354","author":"Barlogie","year":"2006","journal-title":"N Engl J Med"},{"key":"R15-10-20250330","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3324\/haematol.10454","article-title":"Prothrombotic coagulation abnormalities in patients with newly diagnosed multiple myeloma.","volume":"92","author":"Auwerda","year":"2007","journal-title":"Haematologica"},{"key":"R16-10-20250330","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/01.tp.0000191624.70135.35","article-title":"Respiratory complications: a major concern after right hepatectomy in living liver donors.","volume":"81","author":"Dondero","year":"2006","journal-title":"Transplantation"},{"key":"R17-10-20250330","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1160\/TH07-03-0221","article-title":"Hypercoagulability after partial liver resection.","volume":"98","author":"Bezeaud","year":"2007","journal-title":"Thromb Haemost"},{"key":"R18-10-20250330","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1093\/qjmed\/90.12.773","article-title":"Presentation and survival of patients with severe renal failure and myeloma.","volume":"90","author":"Irish","year":"1997","journal-title":"QJM"},{"key":"R19-10-20250330","first-page":"517","article-title":"Perspectives in multiple myeloma: survival, prognostic factors and disease complications in a single centre between 1975 and 1988.","volume":"79","author":"Rayner","year":"1991","journal-title":"Q J Med"},{"key":"R20-10-20250330","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1007\/s002770100330","article-title":"Risk factors for early death in patients undergoing treatment for multiple myeloma.","volume":"80","author":"Murakami","year":"2001","journal-title":"Ann Hematol"},{"key":"R21-10-20250330","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/0002-9343(81)90303-X","article-title":"Influence of treatment and response status on infection risk in multiple myeloma.","volume":"71","author":"Perri","year":"1981","journal-title":"Am J Med"},{"key":"R22-10-20250330","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1080\/10428190601126602","article-title":"Renal failure in multiple myeloma: incidence, correlations, and prognostic significance.","volume":"48","author":"EleutherakisPapaiakovou","year":"2007","journal-title":"Leuk Lymphoma"},{"key":"R23-10-20250330","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1136\/bmj.288.6428.1411","article-title":"MRC myelomatosis trial: MRC working group party on leukaemia in adults.","volume":"288","year":"1984","journal-title":"Br Med J (Clin Res Ed)"},{"key":"R24-10-20250330","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/j.1365-2141.2007.06705.x","article-title":"Immunodeficiency and immunotherapy in multiple myeloma.","volume":"138","author":"Pratt","year":"2007","journal-title":"Br J Haematol"}],"container-title":["Liver Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flt.21685","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flt.21685","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01445473-200903000-00010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T23:33:59Z","timestamp":1743377639000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01445473-200903000-00010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1002\/lt.21685","relation":{},"ISSN":["1527-6465"],"issn-type":[{"value":"1527-6465","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3]]}}}