{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T21:33:03Z","timestamp":1789162383965,"version":"build-2803163510"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2009,6,26]],"date-time":"2009-06-26T00:00:00Z","timestamp":1245974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:title>\n                           <jats:bold>Abstract<\/jats:bold>\n                        <\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>Hepatosplenic \u03b3\u03b4 T-cell lymphoma is a rare lymphoproliferative disorder originating from natural killer\u2013like V\u03b41-lymphocytes. This subtype has been described after different types of solid organ transplants. In this article, we describe the first 2 cases after liver transplantation. Both patients had thrombocytopenia with (hepato)splenomegaly but without peripheral lymphadenopathies and sinusoidal infiltration of the liver and spleen by monomorphic \u03b3\u03b4-lymphocytes on pathological examination. The clinical and pathological findings, immunophenotypical profile, prognosis, and treatment are highlighted. In order to make an early diagnosis, physicians who take care of liver transplant recipients should be aware of the characteristic features of this posttransplant lymphoproliferative disorder. Therefore, a diagnostic algorithm is proposed. Liver Transpl 15:686\u2013692, 2009. \u00a9 2009 AASLD.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/lt.21748","type":"journal-article","created":{"date-parts":[[2009,6,26]],"date-time":"2009-06-26T14:28:15Z","timestamp":1246026495000},"page":"686-692","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":22,"title":["Hepatosplenic \u03b3\u03b4 T-Cell Lymphoma After Liver Transplantation: Report of the First 2 Cases and Review of the Literature"],"prefix":"10.1097","volume":"15","author":[{"given":"Philip R.","family":"Roelandt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Maertens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Vandenberghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Verslype","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Roskams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Aerts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Nevens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daan","family":"Dierickx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-4-20250326","doi-asserted-by":"crossref","first-page":"3626","DOI":"10.1182\/blood.V88.9.3626.bloodjournal8893626","article-title":"Posttransplant Tcell lymphoproliferative disorderan aggressive, late complication of solidorgan transplantation.","volume":"88","author":"Hanson","year":"1996","journal-title":"Blood"},{"key":"R3-4-20250326","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/sj.leu.2401784","article-title":"Hepatosplenic T cell lymphoma. 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ASTSASTP EBVPTLD Task Force and the Mayo Clinic Organized International Consensus Development Meeting.","volume":"68","author":"Paya","year":"1999","journal-title":"Transplantation"},{"key":"R41-4-20250326","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1034\/j.1399-0012.2003.00054.x","article-title":"Humanized antiCD20 monoclonal antibody (Rituximab) treatment for posttransplant lymphoproliferative disorder.","volume":"17","author":"Ganne","year":"2003","journal-title":"Clin Transpl"},{"key":"R42-4-20250326","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1432-2277.2003.tb00286.x","article-title":"AntiCD20 monoclonal antibody treatment of EpsteinBarr virusinduced intrahepatic lymphoproliferative disorder following liver transplantation.","volume":"16","author":"Yedibela","year":"2003","journal-title":"Transpl Int"}],"container-title":["Liver Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flt.21748","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flt.21748","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01445473-200907000-00004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T14:27:57Z","timestamp":1743258477000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01445473-200907000-00004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1002\/lt.21748","relation":{},"ISSN":["1527-6465"],"issn-type":[{"value":"1527-6465","type":"print"}],"subject":[],"published":{"date-parts":[[2009,7]]}}}