{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T09:50:06Z","timestamp":1780998606710,"version":"3.54.1"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2009,9,29]],"date-time":"2009-09-29T00:00:00Z","timestamp":1254182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001424","name":"American Liver Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001424","id-type":"DOI","asserted-by":"crossref"}]},{"name":"American Association for the Study of Liver Diseases through the Jan Albrecht Award"},{"name":"Veterans Affairs Puget Sound Health Care System through the Research Enhancement Award Program"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["T32"],"award-info":[{"award-number":["T32"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000102","name":"Health Resources and Services Administration","doi-asserted-by":"crossref","award":["231-00-0115"],"award-info":[{"award-number":["231-00-0115"]}],"id":[{"id":"10.13039\/100000102","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>Liver transplantation using grafts from donors with antibody against hepatitis B core antigen (anti-HBc) increases the recipients' risk of developing hepatitis B virus (HBV) infection post-transplantation. Our aim was to assess whether using such grafts was associated with reduced posttransplantation survival and whether this association depended on recipients' prior exposure to HBV on the basis of their pretransplantation serological patterns. Data were derived from the United Network for Organ Sharing on adult, cadaveric, first-time liver transplants performed between 1994 and 2006. Among recipients who did not have HBV infection before transplantation, those with anti-HBc\u2013positive donors had significantly worse unadjusted posttransplantation patient survival than recipients with anti-HBc\u2013negative donors [hazard ratio, 1.35; 95% confidence interval (CI), 1.21-1.50]. However, after adjustments for other predictors of posttransplantation survival, including donor age, donor race, and recipient underlying liver diseases, patient survival was not significantly different between the 2 groups (hazard ratio, 1.09; 95% CI, 0.97-1.24). Among recipients without antibody against hepatitis B surface antigen (anti-HBs), use of anti-HBc\u2013positive donor grafts was associated with a trend toward worse survival (adjusted hazard ratio, 1.18; 95% CI, 0.95-1.46), whereas no such trend was observed among recipients positive for anti-HBs. In conclusion, in patients without HBV infection before transplantation, using anti-HBc\u2013positive donors was not independently associated with worse posttransplantation survival. Matching these donors to recipients with anti-HBs pre-transplantation may be especially safe. Liver Transpl 15:1343\u20131350, 2009. \u00a9 2009 AASLD.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/lt.21788","type":"journal-article","created":{"date-parts":[[2009,9,29]],"date-time":"2009-09-29T13:54:22Z","timestamp":1254232462000},"page":"1343-1350","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":32,"title":["Survival after orthotopic liver transplantation: The impact of antibody against hepatitis B core antigen in the donor"],"prefix":"10.1097","volume":"15","author":[{"given":"Lei","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Koepsell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Manhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Ioannou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-28-20250326","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/00007890-199501270-00014","article-title":"The risk of transmission of hepatitis B from HBsAg(), HBcAb(), HBIgM() organ donors.","volume":"59","author":"Wachs","year":"1995","journal-title":"Transplantation"},{"key":"R2-28-20250326","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1053\/gast.1997.v113.pm9352871","article-title":"Transmission of hepatitis B by transplantation of livers from donors positive for antibody to hepatitis B core antigen. The National Institute of Diabetes and Digestive and Kidney Diseases Liver Transplantation Database.","volume":"113","author":"Dickson","year":"1997","journal-title":"Gastroenterology"},{"key":"R3-28-20250326","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1053\/jlts.2001.20786","article-title":"De novo hepatitis B after liver transplantation from hepatitis B core antibodypositive donors in an area with high prevalence of antiHBc positivity in the donor population.","volume":"7","author":"Prieto","year":"2001","journal-title":"Liver Transpl"},{"key":"R4-28-20250326","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/lt.500030202","article-title":"The clinical course of transplantationassociated de novo hepatitis B infection in the liver transplant recipient.","volume":"3","author":"Douglas","year":"1997","journal-title":"Liver Transpl Surg"},{"key":"R5-28-20250326","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1097\/00007890-199712150-00013","article-title":"Infectivity of hepatic allografts with antibodies to hepatitis B virus.","volume":"64","author":"Dodson","year":"1997","journal-title":"Transplantation"},{"key":"R6-28-20250326","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1053\/jlts.2002.33451","article-title":"Safe use of livers from donors with positive hepatitis B core antibody.","volume":"8","author":"Manzarbeitia","year":"2002","journal-title":"Liver Transpl"},{"key":"R7-28-20250326","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1172\/JCI116950C1","article-title":"Hepatitis B virus persistence after recovery from acute viral hepatitis.","volume":"94","author":"Michalak","year":"1994","journal-title":"J Clin Invest"},{"key":"R8-28-20250326","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/0016-5085(91)90599-G","article-title":"Reactivation of hepatitis B virus replication in patients receiving cytotoxic therapy. Report of a prospective study.","volume":"100","author":"Lok","year":"1991","journal-title":"Gastroenterology"},{"key":"R9-28-20250326","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1097\/00007890-199910150-00028","article-title":"Prevention of de novo hepatitis B infection in recipients of hepatic allografts from antiHBc positive donors.","volume":"68","author":"Dodson","year":"1999","journal-title":"Transplantation"},{"key":"R10-28-20250326","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1053\/jlts.2001.23911","article-title":"Transmission of hepatitis B infection from hepatitis B core antibody-positive liver allografts is prevented by lamivudine therapy.","volume":"7","author":"Yu","year":"2001","journal-title":"Liver Transpl"},{"key":"R12-28-20250326","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1136\/gut.50.1.95","article-title":"Antibodies to hepatitis B surface antigen prevent viral reactivation in recipients of liver grafts from antiHBC 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