{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T16:19:47Z","timestamp":1756311587142,"version":"3.40.3"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":2191,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>The purpose of this study was to investigate the effectiveness of the combined use of intravenous morphine and intramuscular glucagon in improving magnetic resonance cholangiopancreatography (MRCP) image quality in donors for living-related liver transplantation. Sixteen healthy donor candidates underwent an MRCP study. Coronal, single-shot, fast spin-echo, heavily T2-weighted dynamic MRCP images were obtained before and 3 minutes after the intravenous administration of morphine HCl with a dose of 0.04 mg\/kg. Thirty minutes after the injection of morphine, intramuscular glucagon was used. Another MRCP image of the same pulse sequence was generated 15 minutes after the injection of glucagon with a dose of 1 mg. The diameter, signal intensity, and number of branches of bile ducts in MRCP images taken immediately before and after the injection of morphine and after the injection of glucagon (plus delayed morphine effects) were compared and analyzed. In all 16 donor candidates, the diameters of the right and left hepatic ducts, common bile duct, and main pancreatic duct were significantly increased (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.05) in the MRCP images taken 3 minutes after the injection of morphine and 15 minutes after the injection of glucagon (plus delayed morphine effects) in comparison with MRCP images taken before any drug administration. The qualitative grading scores of the signal intensity and order of branches of bile ducts revealed improvements in the MRCP images after the injection of glucagon (plus delayed morphine effects; <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.05). In conclusion, combining the intravenous administration of low-dose morphine and the intramuscular use of glucagon before MRCP examination improves the visualization of the nondilated biliary ductal anatomy, which is important for the preoperative biliary evaluation of donor candidates for living-related liver transplantation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/lt.21789","type":"journal-article","created":{"date-parts":[[2009,8,28]],"date-time":"2009-08-28T13:12:29Z","timestamp":1251465149000},"page":"1021-1027","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":9,"title":["Morphine- and glucagon-augmented magnetic resonance cholangiopancreatography to evaluate living liver donors"],"prefix":"10.1097","volume":"15","author":[{"given":"Yuan Heng","family":"Mo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po Chin","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming Chih","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po Huang","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu Shan","family":"Jaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven Shinn-Forng","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-5-20250327","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1055\/s-2007-1004160","article-title":"Clinical significance of magnetic resonance cholangiopancreatography (MRCP) compared to endoscopic retrograde cholangiopancreatography (ERCP).","volume":"29","author":"Hintze","year":"1997","journal-title":"Endoscopy"},{"key":"R2-5-20250327","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.2214\/ajr.171.5.9798883","article-title":"Value of MR cholangiopancreatography in evaluating choledochal cysts.","volume":"171","author":"Irie","year":"1998","journal-title":"AJR Am J Roentgenol"},{"key":"R3-5-20250327","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1136\/gut.43.5.680","article-title":"A prospective evaluation of magnetic resonance cholangiopancreatography in patients with suspected bile duct obstruction.","volume":"43","author":"Adamek","year":"1998","journal-title":"Gut"},{"key":"R4-5-20250327","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1148\/radiology.210.3.r99fe55605","article-title":"Comparison of endoscopic retrograde cholangiopancreatography with MR cholangiopancreatography in patients with pancreatitis.","volume":"210","author":"Sica","year":"1999","journal-title":"Radiology"},{"key":"R5-5-20250327","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1067\/mge.2002.120324","article-title":"Prospective assessment of magnetic resonance cholangiopancreatography for noninvasive imaging of the biliary tree.","volume":"55","author":"Taylor","year":"2002","journal-title":"Gastrointest Endosc"},{"key":"R6-5-20250327","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S0720-048X(03)00084-6","article-title":"Does intravenous glucagon improve common bile duct visualisation during magnetic resonance cholangiopancreatography? Results in 42 patients.","volume":"49","author":"Dalal","year":"2004","journal-title":"Eur J Radiol"},{"key":"R7-5-20250327","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1007\/s00261-005-0155-5","article-title":"Fentanylaugmented MRCP.","volume":"31","author":"Agarwal","year":"2006","journal-title":"Abdom Imaging"},{"key":"R8-5-20250327","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.3748\/wjg.v10.i19.2901","article-title":"Effects of narcotic analgesic drugs on human Oddis sphincter motility.","volume":"10","author":"Wu","year":"2004","journal-title":"World J Gastroenterol"},{"key":"R9-5-20250327","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1148\/rg.243035087","article-title":"MR cholangiopancreatography: improved ductal distention with intravenous morphine administration.","volume":"24","author":"Silva","year":"2004","journal-title":"Radiographics"},{"key":"R10-5-20250327","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/S0016-5107(03)02303-4","article-title":"Secretin MRCP and endoscopic pancreatic manometry in the evaluation of sphincter of Oddi function: a comparative pilot study in patients with idiopathic recurrent pancreatitis.","volume":"58","author":"Mariani","year":"2003","journal-title":"Gastrointest Endosc"},{"key":"R11-5-20250327","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1148\/radiographics.22.3.g02ma20477","article-title":"Pharmacologic interventions in nuclear radiology: indications, imaging protocols, and clinical results.","volume":"22","author":"Saremi","year":"2002","journal-title":"Radiographics"},{"key":"R12-5-20250327","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/jmri.10446","article-title":"The utility of MRCP in preoperative mapping of biliary anatomy in adulttoadult living related liver transplant donors.","volume":"19","author":"Limanond","year":"2004","journal-title":"J Magn Reson Imaging"},{"key":"R13-5-20250327","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1148\/radiol.2333031977","article-title":"Defining intrahepatic biliary anatomy in living liver transplant donor candidates at mangafodipir trisodiumenhanced MR cholangiography versus conventional T2weighted MR cholangiography.","volume":"233","author":"Lee","year":"2004","journal-title":"Radiology"},{"key":"R14-5-20250327","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.2214\/ajr.179.5.1791281","article-title":"Intrahepatic biliary anatomy of living adult liver donors: correlation of mangafodipir trisodiumenhanced MR cholangiography and intraoperative cholangiography.","volume":"179","author":"Kapoor","year":"2002","journal-title":"AJR Am J Roentgenol"},{"key":"R15-5-20250327","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.2214\/ajr.176.6.1761475","article-title":"MR imaging as the sole preoperative imaging modality for right hepatectomy: a prospective study of living adulttoadult liver donor candidates.","volume":"176","author":"Lee","year":"2001","journal-title":"AJR Am J Roentgenol"},{"key":"R16-5-20250327","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.2214\/ajr.176.6.1761483","article-title":"Right lobe living donor liver transplantation: preoperative evaluation of the donor with MR imaging.","volume":"176","author":"Fulcher","year":"2001","journal-title":"AJR Am J Roentgenol"},{"key":"R17-5-20250327","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1097\/00007890-200111150-00010","article-title":"Single imaging modality evaluation of living donors in liver transplantation: magnetic resonance imaging.","volume":"72","author":"Cheng","year":"2001","journal-title":"Transplantation"},{"key":"R18-5-20250327","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1148\/radiology.206.2.9457189","article-title":"Optimal MR cholangiopancreatographic sequence and its clinical application.","volume":"206","author":"Irie","year":"1998","journal-title":"Radiology"},{"key":"R19-5-20250327","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1148\/radiology.181.3.1947101","article-title":"Dilated biliary tract: evaluation with MR cholangiography with a T2weighted contrastenhanced fast sequence.","volume":"181","author":"Wallner","year":"1991","journal-title":"Radiology"},{"key":"R20-5-20250327","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/j.1445-1433.2004.03114.x","article-title":"Magnetic resonance imaging of the common bile duct to exclude choledocholithiasis.","volume":"74","author":"Kejriwal","year":"2004","journal-title":"ANZ J Surg"},{"key":"R21-5-20250327","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1007\/s00464-002-8704-2","article-title":"Role of endoscopic retrograde cholangiopancreatography in the management of suspected choledocholithiasis.","volume":"17","author":"Sharma","year":"2003","journal-title":"Surg Endosc"},{"key":"R22-5-20250327","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1067\/mge.2002.124206","article-title":"A prospective comparison of the diagnostic accuracy of ERCP, MRCP, CT, and EUS in biliary strictures.","volume":"55","author":"Rosch","year":"2002","journal-title":"Gastrointest Endosc"},{"key":"R23-5-20250327","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1148\/radiographics.22.1.g02jae2e2","article-title":"MR imaging of the pancreas: a pictorial tour.","volume":"22","author":"Matos","year":"2002","journal-title":"Radiographics"},{"key":"R24-5-20250327","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/S0033-8389(02)00056-8","article-title":"MR imaging of the pancreas: a practical approach.","volume":"40","author":"Ly","year":"2002","journal-title":"Radiol Clin North Am"},{"key":"R25-5-20250327","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1046\/j.0007-1323.2002.02066.x","article-title":"Comparison of magnetic resonance cholangiography and percutaneous transhepatic cholangiography in the evaluation of bile duct strictures after cholecystectomy.","volume":"89","author":"Chaudhary","year":"2002","journal-title":"Br J Surg"},{"key":"R26-5-20250327","doi-asserted-by":"crossref","first-page":"389","DOI":"10.2214\/ajr.177.2.1770389","article-title":"Anatomic variants of the biliary tree: MR cholangiographic findings and clinical applications.","volume":"177","author":"Mortele","year":"2001","journal-title":"AJR Am J Roentgenol"},{"key":"R27-5-20250327","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3348\/kjr.2003.4.2.85","article-title":"Anatomic variation in intrahepatic bile ducts: an analysis of intraoperative cholangiograms in 300 consecutive donors for living donor liver transplantation.","volume":"4","author":"Choi","year":"2003","journal-title":"Korean J Radiol"},{"key":"R28-5-20250327","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1007\/s005340070033","article-title":"Anatomical keys and pitfalls in living donor liver transplantation.","volume":"7","author":"Imamura","year":"2000","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"R29-5-20250327","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1002\/jmri.21485","article-title":"Navigatortriggered prospective acquisition correction (PACE) technique versus conventional respiratorytriggered technique for freebreathing 3D MRCP: an initial prospective comparative study using healthy volunteers.","volume":"28","author":"Morita","year":"2008","journal-title":"J Magn Reson Imaging"},{"key":"R30-5-20250327","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1148\/radiographics.20.4.g00jl23939","article-title":"MR cholangiopancreatography of bile and pancreatic duct abnormalities with emphasis on the singleshot fast spinecho technique.","volume":"20","author":"Vitellas","year":"2000","journal-title":"Radiographics"},{"key":"R31-5-20250327","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1148\/radiology.203.2.9114101","article-title":"Pancreatic duct: morphologic and functional evaluation with dynamic MR pancreatography after secretin stimulation.","volume":"203","author":"Matos","year":"1997","journal-title":"Radiology"},{"key":"R32-5-20250327","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0002-9610(98)00148-2","article-title":"A new evaluation of pancreatic function after pancreatoduodenectomy using secretin magnetic resonance cholangiopancreatography.","volume":"176","author":"Sho","year":"1998","journal-title":"Am J Surg"},{"key":"R33-5-20250327","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.2214\/ajr.147.6.1177","article-title":"Morphineaugmented cholescintigraphy in the diagnosis of acute cholecystitis.","volume":"147","author":"Kim","year":"1986","journal-title":"AJR Am J Roentgenol"}],"container-title":["Liver Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flt.21789","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01445473-200909000-00005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T05:45:27Z","timestamp":1743313527000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01445473-200909000-00005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":33,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1002\/lt.21789","relation":{},"ISSN":["1527-6465"],"issn-type":[{"type":"print","value":"1527-6465"}],"subject":[],"published":{"date-parts":[[2009,9]]}}}