{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:42:21Z","timestamp":1788871341294,"version":"build-2803163510"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2009,9,29]],"date-time":"2009-09-29T00:00:00Z","timestamp":1254182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Fondo de Investigaciones Sanitarias","award":["grants FIS 03\/0559"],"award-info":[{"award-number":["grants FIS 03\/0559"]}]},{"name":"Fondo de Investigaciones Sanitarias","award":["05\/0230"],"award-info":[{"award-number":["05\/0230"]}]},{"name":"Red Espa\u00f1ola de Investigaci\u00f3n en Patolog\u00eda Infecciosa","award":["RD06\/0008\/1013"],"award-info":[{"award-number":["RD06\/0008\/1013"]}]},{"name":"Spanish Network for Research on Infection in Organ Transplantation"},{"name":"Mutua Madrile\u00f1a Automovil\u00edstica Foundation","award":["2004"],"award-info":[{"award-number":["2004"]}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Mannose-binding lectin (MBL) is a C-type lectin produced mainly by the liver that binds to a wide range of pathogens. Polymorphisms at the promoter and exon 1 of the\n                      <jats:italic toggle=\"yes\">MBL2<\/jats:italic>\n                      gene are responsible for low serum levels of MBL and have been associated with an increased risk of infections. We prospectively analyzed 95 liver transplant recipients. Well-known functionally relevant polymorphisms of the\n                      <jats:italic toggle=\"yes\">MBL2<\/jats:italic>\n                      gene of the liver donor were examined by gene sequencing. Infectious events were collected prospectively. No differences in the incidence of infections were found according to the donor\n                      <jats:italic toggle=\"yes\">MBL2<\/jats:italic>\n                      genotypes. Survival was lower in patients receiving a liver graft from a donor with an exon 1\n                      <jats:italic toggle=\"yes\">MBL2<\/jats:italic>\n                      variant genotype, and they had higher infection-related mortality (50% versus 14%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.040). No differences were found according to other polymorphisms involving the promoter and 5\u2032-untranslated region. When we analyzed bacterial infection episodes, we found that patients receiving a liver from a donor with an exon 1 variant genotype had a higher incidence of septic shock (46% versus 11%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.004). Independent variables associated with graft or patient survival were as follows: receiving a graft from a donor with an exon 1\n                      <jats:italic toggle=\"yes\">MBL2<\/jats:italic>\n                      variant genotype [adjusted hazard ratio (aHR), 9.64; 95% confidence interval (CI), 2.59-36.0], the Model for End-Stage Liver Disease score (aHR, 1.14; 95% CI, 1.05-1.23), and bacterial infections (aHR, 11.1; 95% CI, 2.73-44.9). Liver transplantation from a donor with a variant\n                      <jats:italic toggle=\"yes\">MBL2<\/jats:italic>\n                      exon 1 genotype was associated with a worse prognosis, mainly because of infections of higher severity. Liver Transpl 15:1217\u20131224, 2009. \u00a9 2009 AASLD.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lt.21834","type":"journal-article","created":{"date-parts":[[2009,9,29]],"date-time":"2009-09-29T09:54:22Z","timestamp":1254218062000},"page":"1217-1224","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":45,"title":["Donor mannose-binding lectin gene polymorphisms influence the outcome of liver transplantation"],"prefix":"10.1097","volume":"15","author":[{"given":"Carlos","family":"Cervera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domingo","family":"Balderramo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bel\u00e9n","family":"Su\u00e1rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jhon","family":"Prieto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Fuster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Linares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Fuster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asunci\u00f3n","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Lozano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miquel","family":"Navasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-11-20250326","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1086\/379324","article-title":"Impact 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