{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:45:04Z","timestamp":1791773104419,"version":"4.3.4"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2010,5,18]],"date-time":"2010-05-18T00:00:00Z","timestamp":1274140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:sec>\n            <jats:title>Abstract<\/jats:title>\n            <jats:p>Portal vein thrombosis (PVT) complicates the liver transplant operation and potentially affects waiting list survival. The implications on calculations of survival benefit, which balance both waiting list and posttransplant survival effects of PVT, have not been determined. The objective of this study is to describe the effect of PVT on the survival benefit of liver transplantation. Using Scientific Registry of Transplant Recipients data on adult liver transplant candidates wait-listed between September 2001 and December 2007, Cox proportional hazard models were fitted to estimate the covariate-adjusted effect of PVT on transplant rate, waiting list survival, and posttransplant survival. We then used sequential stratification to estimate liver transplant survival benefit by cross-classifications defined by Model for End-Stage Liver Disease (MELD) score and PVT status. The prevalence of reported PVT among 22,291 liver transplant recipients was 4.02% (N = 897). PVT was not a predictor of waiting list mortality (hazard ratio = 0.90, <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.23) but was a predictor of posttransplant mortality (hazard ratio = 1.32, <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.02). Overall, transplant benefit was not significantly different for patients with PVT versus without PVT (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.21), but there was a shift in the benefit curve. Specifically, the threshold for transplant benefit among patients without PVT was MELD score &gt;11 compared to MELD score &gt;13 for patients with PVT. PVT is associated with significantly higher posttransplant mortality but does not affect waiting list mortality. Among patients with low MELD score, PVT is associated with less transplant survival benefit. Clinicians should carefully consider the risks of liver transplantation in clinically stable patients who have PVT. Liver Transpl 16:999-1005, 2010. \u00a9 2010 AASLD.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/lt.22105","type":"journal-article","created":{"date-parts":[[2010,5,18]],"date-time":"2010-05-18T23:21:39Z","timestamp":1274224899000},"page":"999-1005","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":203,"title":["Portal vein thrombosis and liver transplant survival benefit"],"prefix":"10.1097","volume":"16","author":[{"given":"Michael J.","family":"Englesbe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas E.","family":"Schaubel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijie","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary K.","family":"Guidinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Merion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-10-20250203","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.jhep.2004.01.001","article-title":"Risk factors and clinical presentation of portal vein thrombosis in patients with liver cirrhosis.","volume":"40","author":"Amitrano","year":"2004","journal-title":"J Hepatol"},{"key":"R2-10-20250203","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.3748\/wjg.v12.i13.2115","article-title":"Portal vein thrombosis: prevalence, patient characteristics and lifetime risk: a population study based on 23,796 consecutive autopsies.","volume":"12","author":"Ogren","year":"2006","journal-title":"World J Gastroenterol"},{"key":"R3-10-20250203","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1136\/gut.49.5.720","article-title":"Extrahepatic portal vein thrombosis: aetiology and determinants of survival.","volume":"49","author":"Janssen","year":"2001","journal-title":"Gut"},{"key":"R4-10-20250203","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1002\/hep.510310307","article-title":"Cause of portal or hepatic venous thrombosis in adults: the role of multiple concurrent factors.","volume":"31","author":"Denninger","year":"2000","journal-title":"Hepatology"},{"key":"R5-10-20250203","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1751-553X.2007.00973.x","article-title":"The JAK2(V617F) tyrosine kinase mutation identifies clinically latent myeloproliferative disorders in patients presenting with hepatic or portal vein thrombosis.","volume":"30","author":"Goulding","year":"2008","journal-title":"Int J Lab Hematol"},{"key":"R7-10-20250203","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1097\/00000658-200202000-00019","article-title":"Thrombendvenectomy for organized portal vein thrombosis at the time of liver transplantation.","volume":"235","author":"Molmenti","year":"2002","journal-title":"Ann Surg"},{"key":"R8-10-20250203","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1471-230X-7-34","article-title":"Portal vein thrombosis; risk factors, clinical presentation and treatment.","volume":"7","author":"Sogaard","year":"2007","journal-title":"BMC Gastroenterol"},{"key":"R10-10-20250203","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1111\/j.1600-6143.2008.02400.x","article-title":"Survival outcomes following liver transplantation (SOFT) score: a novel method to predict patient survival following liver transplantation.","volume":"8","author":"Rana","year":"2008","journal-title":"Am J Transplant"},{"key":"R12-10-20250203","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0168-8278(00)80259-7","article-title":"Portal vein thrombosis in adults: pathophysiology, pathogenesis and management.","volume":"32","author":"Valla","year":"2000","journal-title":"J Hepatol"},{"key":"R13-10-20250203","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/lt.21941","article-title":"Portal vein thrombosis and survival in patients with cirrhosis.","volume":"16","author":"Englesbe","year":"2010","journal-title":"Liver Transpl"},{"key":"R14-10-20250203","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/j.1600-6143.2006.01242.x","article-title":"Characteristics associated with liver graft failure: the concept of a donor risk index.","volume":"6","author":"Feng","year":"2006","journal-title":"Am J Transplant"},{"key":"R15-10-20250203","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1198\/jasa.2009.0003","article-title":"Estimating the effect of a time-dependent treatment by levels of an internal time-dependent covariate: Application to the contrast between liver wait-list and posttransplant mortality.","volume":"104","author":"Schaubel","year":"2009","journal-title":"J Am Stat Assoc"},{"key":"R16-10-20250203","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1111\/j.1541-0420.2006.00527.x","article-title":"A sequential stratification method for estimating the effect of a time-dependent experimental treatment in observational studies.","volume":"62","author":"Schaubel","year":"2006","journal-title":"Biometrics"},{"key":"R17-10-20250203","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1600-6143.2007.02086.x","article-title":"The survival benefit of deceased donor liver transplantation as a function of candidate disease severity and donor quality.","volume":"8","author":"Schaubel","year":"2008","journal-title":"Am J Transplant"},{"key":"R20-10-20250203","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1600-6143.2004.00703.x","article-title":"The survival benefit of liver transplantation.","volume":"5","author":"Merion","year":"2005","journal-title":"Am J Transplant"},{"key":"R21-10-20250203","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1006\/jsre.1996.0053","article-title":"A high incidence of native portal vein thrombosis in veterans undergoing liver transplantation.","volume":"60","author":"Gayowski","year":"1996","journal-title":"J Surg Res"},{"key":"R22-10-20250203","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/j.1600-6143.2006.01649.x","article-title":"Ten-year experience in porto-caval hemitransposition for liver transplantation in the presence of portal vein thrombosis.","volume":"7","author":"Selvaggi","year":"2007","journal-title":"Am J Transplant"}],"container-title":["Liver Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flt.22105","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flt.22105","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01445473-201008000-00010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T19:00:17Z","timestamp":1738609217000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01445473-201008000-00010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":17,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1002\/lt.22105","relation":{},"ISSN":["1527-6465"],"issn-type":[{"value":"1527-6465","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8]]}}}