{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:13:51Z","timestamp":1780395231912,"version":"3.54.1"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2011,3,28]],"date-time":"2011-03-28T00:00:00Z","timestamp":1301270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:sec>\n            <jats:title>Abstract<\/jats:title>\n            <jats:p>Liver transplant recipients have an increased risk of malignancy. Smoking is related to some of the most frequent causes of posttransplant malignancy. The incidence and risk factors for the development of neoplasia related to smoking (head and neck, lung, esophageal, and kidney and urinary tract carcinomas) were studied in 339 liver transplant recipients. Risk factors for the development of smoking-related neoplasia were also studied in 135 patients who had a history of smoking so that it could be determined whether smoking withdrawal was associated with a lower risk of malignancy. After a mean follow-up of 7.5 years, 26 patients were diagnosed with 29 smoking-related malignancies. The 5- and 10-year actuarial rates were 5% and 13%, respectively. In multivariate analysis, smoking and older age were independently associated with a higher risk of malignancy. In the smoker subgroup, the variables related to a higher risk of malignancy were active smoking and older age. In conclusion, smoking withdrawal after liver transplantation may have a protective effect against the development of neoplasia. <jats:bold>\n                                    Liver Transpl, 2011. \u00a9 2011 AASLD.\n                                 <\/jats:bold>\n                              <\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/lt.22247","type":"journal-article","created":{"date-parts":[[2011,1,10]],"date-time":"2011-01-10T14:08:13Z","timestamp":1294668493000},"page":"402-408","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":97,"title":["Risk factors of lung, head and neck, esophageal, and kidney and urinary tract carcinomas after liver transplantation"],"prefix":"10.1097","volume":"17","author":[{"given":"Ignacio J.","family":"Herrero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Pardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delia","family":"D'Avola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e9lix","family":"Alegre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Rotellar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"I\u00f1arrairaegui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Mart\u00ed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Sangro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Quiroga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"suppl 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complications.","volume":"10","author":"Herrero","year":"2004","journal-title":"Liver Transpl"},{"key":"R14-7-20250124","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/j.1399-0012.2008.00927.x","article-title":"Usefulness of a program of neoplasia surveillance in liver transplantation. A preliminary report.","volume":"23","author":"Herrero","year":"2009","journal-title":"Clin Transplant"},{"key":"R15-7-20250124","first-page":"245","article-title":"Incidence and mortality due to cancer in Navarre, 1998-2002. Trend in the last 30 years in Spanish.","volume":"30","author":"Ardanaz","year":"2007","journal-title":"An Sist Sanit Navar"},{"key":"R16-7-20250124","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/S0041-1345(98)01994-0","article-title":"Incidence and outcome of de novo malignancies after liver transplantation.","volume":"31","author":"Galve","year":"1999","journal-title":"Transplant Proc"},{"key":"R17-7-20250124","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1111\/j.1600-6143.2004.00380.x","article-title":"De novo internal neoplasms after liver transplantation: increased risk and aggressive behavior in recent years?","volume":"4","author":"Benlloch","year":"2004","journal-title":"Am J Transplant"},{"key":"R18-7-20250124","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1053\/jlts.2002.29350","article-title":"De novo tumors after liver transplantation: a single institution experience.","volume":"8","author":"Sanchez","year":"2002","journal-title":"Liver Transpl"},{"key":"R19-7-20250124","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1002\/lt.21471","article-title":"Smoking-related morbidity and mortality following liver transplantation.","volume":"14","author":"Leithead","year":"2008","journal-title":"Liver Transpl"},{"key":"R20-7-20250124","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1053\/jlts.2002.34150","article-title":"Cigarette smoking is associated with an increased incidence of vascular complications after liver transplantation.","volume":"8","author":"Pungpapong","year":"2002","journal-title":"Liver Transpl"},{"key":"R21-7-20250124","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1432-2277.2010.01146.x","article-title":"The effect of smoking on biliary complications following liver transplantation.","volume":"24","author":"Mathur","year":"2011","journal-title":"Transpl Int"},{"key":"R22-7-20250124","first-page":"74","article-title":"Vascular events after liver transplantation: a long-term follow-up study.","volume":"21","author":"Borg","year":"2008","journal-title":"Transpl Int"},{"key":"R23-7-20250124","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1002\/lt.22064","article-title":"Increased incidence of early de novo cancer in liver graft recipients treated with cyclosporine: an association with C2 monitoring and recipient age.","volume":"16","author":"Tjon","year":"2010","journal-title":"Liver Transpl"},{"key":"R24-7-20250124","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1053\/jlts.2001.22460","article-title":"Prognostic model for early acute rejection after liver transplantation.","volume":"7","author":"Gomez-Manero","year":"2001","journal-title":"Liver Transpl"},{"key":"R25-7-20250124","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1002\/hep.510280306","article-title":"Acute hepatic allograft rejection: incidence, risk factors, and impact on outcome.","volume":"28","author":"Wiesner","year":"1998","journal-title":"HEPATOLOGY"}],"container-title":["Liver Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flt.22247","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flt.22247","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01445473-201104000-00007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T17:04:23Z","timestamp":1737738263000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01445473-201104000-00007"}},"subtitle":["The effect of smoking withdrawal a"],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1002\/lt.22247","relation":{},"ISSN":["1527-6465"],"issn-type":[{"value":"1527-6465","type":"print"}],"subject":[],"published":{"date-parts":[[2011,4]]}}}