{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T15:47:45Z","timestamp":1782316065426,"version":"3.54.5"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2011,6,27]],"date-time":"2011-06-27T00:00:00Z","timestamp":1309132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>The study objectives were to determine whether the findings of the Adult-to-Adult Living Donor Liver Transplantation Cohort Study (A2ALL) reflect the U.S. national experience and to define risk factors for patient mortality and graft loss in living donor liver transplantation (LDLT). A2ALL previously identified risk factors for mortality after LDLT, which included early center experience, older recipient age, and longer cold ischemia time. LDLT procedures at 9 A2ALL centers (<jats:italic toggle=\"yes\">n<\/jats:italic> = 702) and 67 non-A2ALL centers (<jats:italic toggle=\"yes\">n<\/jats:italic> = 1664) from January 1998 through December 2007 in the Scientific Registry of Transplant Recipients database were analyzed. Potential predictors of time from transplantation to death or graft failure were tested using Cox regression. No significant difference in overall mortality between A2ALL and non-A2ALL centers was found. Higher hazard ratios (HRs) were associated with donor age (HR = 1.13 per 10 years, <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.0002), recipient age (HR = 1.20 per 10 years, <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.0003), serum creatinine levels (HR = 1.52 per loge unit increase, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.0001), hepatocellular carcinoma (HR = 2.12, <jats:italic toggle=\"yes\">P<\/jats:italic>&lt;0.0001) or hepatitis C virus (HR = 1.18, <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.026), intensive care unit stay (HR = 2.52, <jats:italic toggle=\"yes\">P<\/jats:italic>&lt; 0.0001) or hospitalization (HR = 1.62, P &lt; 0.0001) versus home, earlier center experience (LDLT case number 15: HR = 1.61, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.0001, and a cold ischemia time &gt;4.5 hours (HR = 1.79, <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.0006). Except for center experience, risk factor effects between A2ALL and non-A2ALL centers were not significantly different. Variables associated with graft loss were identified and showed similar trends. In conclusion, mortality and graft loss risk factors were similar in A2ALL and non-A2ALL centers. These analyses demonstrate that findings from the A2ALL consortium are relevant to other centers in the U.S. performing LDLT, and conclusions and recommendations from A2ALL may help to guide clinical decision making. Liver Transpl 17:789-797, 2011. \u00a9 2011 AASLD.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/lt.22288","type":"journal-article","created":{"date-parts":[[2011,2,26]],"date-time":"2011-02-26T15:51:49Z","timestamp":1298735509000},"page":"789-797","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":103,"title":["Outcomes of Adult Living Donor Liver Transplantation"],"prefix":"10.1097","volume":"17","author":[{"given":"Kim M.","family":"Olthoff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael M.","family":"Abecassis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean C.","family":"Emond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igal","family":"Kam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Merion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda W.","family":"Gillespie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-6-20250124","doi-asserted-by":"crossref","first-page":"13131316","DOI":"10.1097\/00007890-199811270-00008","article-title":"Adult living donor liver transplantation using a right hepatic lobe.","volume":"66","author":"Wachs","year":"1998","journal-title":"Transplantation"},{"key":"R2-6-20250124","doi-asserted-by":"crossref","first-page":"314323","DOI":"10.1097\/01.sla.0000179646.37145.ef","article-title":"Outcomes of 385 adulttoadult living donor liver transplant recipients: a report from the A2ALL consortium.","volume":"242","author":"Olthoff","year":"2005","journal-title":"Ann Surg"},{"key":"R3-6-20250124","doi-asserted-by":"crossref","first-page":"25692579","DOI":"10.1111\/j.1600-6143.2008.02440.x","article-title":"Recipient morbidity after living and deceased donor liver transplantation: findings from the A2ALL retrospective cohort study.","volume":"8","author":"Freise","year":"2008","journal-title":"Am J Transplant"},{"key":"R4-6-20250124","doi-asserted-by":"crossref","first-page":"468476","DOI":"10.1053\/j.gastro.2008.04.018","article-title":"Donor morbidity after living donation for liver transplantation.","volume":"135","author":"Ghobrial","year":"2008","journal-title":"Gastroenterology"},{"key":"R5-6-20250124","doi-asserted-by":"crossref","first-page":"151158","DOI":"10.1097\/01.sla.0000129340.05238.a0","article-title":"Lessons learned from one hundred right lobe living donor liver transplants.","volume":"240","author":"Lo","year":"2004","journal-title":"Ann Surg"},{"key":"R6-6-20250124","doi-asserted-by":"crossref","first-page":"589598","DOI":"10.1111\/j.1600-6143.2005.01220.x","article-title":"Improved survival after live donor adult liver transplantation (LDALT) using right lobe grafts: program experience and lessons learned.","volume":"6","author":"Pomposelli","year":"2006","journal-title":"Am J Transplant"},{"key":"R7-6-20250124","doi-asserted-by":"crossref","first-page":"9981002","DOI":"10.1111\/j.1600-6143.2006.01692.x","article-title":"Reduced mortality with rightlobe living donor compared to deceaseddonor liver transplantation when analyzed from the time of listing.","volume":"7","author":"Shah","year":"2007","journal-title":"Am J Transplant"},{"key":"R8-6-20250124","doi-asserted-by":"crossref","first-page":"920927","DOI":"10.1111\/j.1600-6143.2004.00462.x","article-title":"Association of center volume with outcome after liver and kidney transplantation.","volume":"4","author":"Axelrod","year":"2004","journal-title":"Am J Transplant"},{"key":"R9-6-20250124","doi-asserted-by":"crossref","first-page":"12501260","DOI":"10.1016\/j.athoracsur.2008.06.071","article-title":"Increased mortality at lowvolume orthotopic heart transplantation centers: should current standards change?","volume":"86","author":"Weiss","year":"2008","journal-title":"Ann Thorac Surg"},{"key":"R10-6-20250124","doi-asserted-by":"crossref","first-page":"511520","DOI":"10.7326\/0003-4819-137-6-200209170-00012","article-title":"Is volume related to outcome in health care? A systematic review and methodologic critique of the literature.","volume":"137","author":"Halm","year":"2002","journal-title":"Ann Intern Med"},{"key":"R11-6-20250124","doi-asserted-by":"crossref","first-page":"21172127","DOI":"10.1056\/NEJMsa035205","article-title":"Surgeon volume and operative mortality in the United States.","volume":"349","author":"Birkmeyer","year":"2003","journal-title":"N Engl J Med"},{"key":"R12-6-20250124","doi-asserted-by":"crossref","first-page":"18061813","DOI":"10.1053\/j.gastro.2007.09.004","article-title":"Improvement in survival associated with adulttoadult living donor liver transplantation.","volume":"133","author":"Berg","year":"2007","journal-title":"Gastroenterology"},{"key":"R13-6-20250124","doi-asserted-by":"crossref","first-page":"301308","DOI":"10.1111\/j.1600-6143.2008.02487.x","article-title":"Incidence and severity of acute cellular rejection in recipients undergoing adult living donor or deceased donor liver transplantation.","volume":"9","author":"Shaked","year":"2009","journal-title":"Am J Transplant"},{"key":"R14-6-20250124","doi-asserted-by":"crossref","first-page":"16211633","DOI":"10.1111\/j.1600-6143.2010.03039.x","article-title":"Database comparison of the AdultToAdult Living Donor Liver Transplantation Cohort Study (A2ALL) and the SRTR U.S. Transplant Registry.","volume":"10","author":"Gillespie","year":"2010","journal-title":"Am J Transplant"}],"container-title":["Liver Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flt.22288","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flt.22288","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01445473-201107000-00006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T17:07:47Z","timestamp":1737738467000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01445473-201107000-00006"}},"subtitle":["Comparison of the Adult-to-Adult Living Donor Liver Transplantation Cohort Study and The National Experience"],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1002\/lt.22288","relation":{},"ISSN":["1527-6465"],"issn-type":[{"value":"1527-6465","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7]]}}}