{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T03:02:38Z","timestamp":1774321358181,"version":"3.50.1"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2011,9,26]],"date-time":"2011-09-26T00:00:00Z","timestamp":1316995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>The ability of interferon-\u03b3 release assays (IGRAs) to detect latent tuberculosis (TB) infection before liver transplantation (LT) is not well established. The aims of this study were (1) to compare the ability of the tuberculin skin test (TST) and the QuantiFERON-TB Gold In-Tube (QFT-IT) test (a whole-blood IGRA) to diagnose latent TB infections in patients awaiting LT and (2) to correlate the results with the severity of liver disease. We conducted a prospective, cross-sectional study of patients who were evaluated for LT between July 2008 and July 2010. The 95 patients who were included underwent the 2-step TST and the QFT-IT test. The mean Model for End-Stage Liver Disease (MELD) score was 13.8. Forty-four patients (46.3%) had positive TST results, 42 (44.2%) had positive QFT-IT results, and 2 (2.1%) had indeterminate QFT-IT results. Simultaneous TST and QFT-IT testing yielded a positivity rate of 55.8% [95% confidence interval (CI) = 45.3-65.9] with either test, and the 2-step TST yielded a positivity rate of 46.3% (95% CI = 36.1-56.8); the difference was 9.5% (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.004). In an adjusted analysis, the rates for positive TST results were lower in patients with MELD scores \u226518 [odds ratio (OR) = 0.2, 95% CI = 0.04-0.7], lower in Child-Pugh-Turcotte (CPT) class C patients versus CPT class A patients (OR = 0.1, 95% CI = 0.02-0.6), and higher in males (OR = 6.4, 95% CI = 1.9-22.0). In contrast, only being male (OR = 3.5, 95% CI = 1.1-11.0) was associated with positive QFT-IT results; no association was found with the MELD score (OR = 0.8, 95% CI = 0.2-2.8) or the CPT class (OR = 0.3; 0.05-1.4). In conclusion, the QFT-IT test is better than the TST for detecting latent TB infection in patients with more advanced liver disease. Our results support the regular use of the QFT-IT test for screening patients with end-stage liver disease for latent TB infection before LT. Liver Transpl 17:1205\u20131211, 2011. \u00a9 2011 AASLD.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/lt.22375","type":"journal-article","created":{"date-parts":[[2011,7,11]],"date-time":"2011-07-11T17:55:45Z","timestamp":1310406945000},"page":"1205-1211","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":49,"title":["Comparison of the 2-step tuberculin skin test and the quantiFERON-TB gold in-tube test for the screening of tuberculosis infection before liver transplantation"],"prefix":"10.1097","volume":"17","author":[{"given":"Susana","family":"Casas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Moure","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Castellote","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria R.","family":"Guerra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Andreu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoni G.","family":"Rafecas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Alcaide","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Santin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-11-20250124","doi-asserted-by":"crossref","first-page":"12661277","DOI":"10.1086\/514993","article-title":"Mycobacterium tuberculosis infection in solidorgan transplant recipients: impact and implications for management.","volume":"27","author":"Singh","year":"1998","journal-title":"Clin Infect Dis"},{"key":"R2-11-20250124","doi-asserted-by":"crossref","first-page":"12781286","DOI":"10.1097\/00007890-199705150-00015","article-title":"Clinical presentation and outcome of tuberculosis in kidney, liver, and heart transplant recipients in Spain. Spanish Transplantation Infection Study Group, GESITRA.","volume":"63","author":"Aguado","year":"1997","journal-title":"Transplantation"},{"issue":"suppl 10","key":"R3-11-20250124","first-page":"3741","article-title":"Am J T","volume":"4","year":"2004","journal-title":"ransplant"},{"key":"R4-11-20250124","doi-asserted-by":"crossref","first-page":"581587","DOI":"10.1086\/427692","article-title":"Mycobacterium tuberculosis infection in recipients of solid organ transplants.","volume":"40","author":"Munoz","year":"2005","journal-title":"Clin Infect Dis"},{"key":"R5-11-20250124","first-page":"16571665","article-title":"; for Spanish Network for Research in Infectious Diseases. Tuberculosis after solidorgan transplant: incidence, risk factors, and clinical characteristics in the RESITRA (Spanish Network of Infection in Transplantation) cohort.","volume":"48","author":"TorreCisneros","year":"2009","journal-title":"Clin Infect Dis"},{"key":"R6-11-20250124","doi-asserted-by":"crossref","first-page":"12761284","DOI":"10.1086\/597590","article-title":"Tuberculosis in solidorgan transplant recipients: consensus statement of the Group for the Study of Infection in Transplant Recipients (GESITRA) of the Spanish Society of Infectious Diseases and Clinical Microbiology.","volume":"48","author":"Aguado","year":"2009","journal-title":"Clin Infect Dis"},{"issue":"suppl 4","key":"R7-11-20250124","first-page":"S57S62","article-title":"Dorman S; and for AST Infectious Diseases Community of Practice. Mycobacterium tuberculosis in solid organ transplant recipients.","volume":"9","author":"Subramanian","year":"2009","journal-title":"Am J Transplant"},{"key":"R8-11-20250124","doi-asserted-by":"crossref","first-page":"894906","DOI":"10.1002\/lt.21709","article-title":"Tuberculosis in liver transplant recipients: a systematic review and metaanalysis of individual patient data.","volume":"15","author":"Holty","year":"2009","journal-title":"Liver Transpl"},{"key":"R9-11-20250124","doi-asserted-by":"crossref","first-page":"303312","DOI":"10.1517\/17530050902758738","article-title":"Interferon gamma release assays for diagnosing active and latent tuberculosis.","volume":"3","author":"Thijsen","year":"2009","journal-title":"Expert Opin Med Diagn"},{"issue":"suppl 1","key":"R10-11-20250124","first-page":"2633","article-title":"Diagnosis of tuberculosis infection using interferonbased assays.","volume":"29","author":"Santin Cerezales","year":"2011","journal-title":"Enferm Infecc Microbiol 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