{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T09:21:03Z","timestamp":1760865663711,"version":"3.33.0"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Supplement 3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1400,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:sec>\n            <jats:title>Key Points<\/jats:title>\n            <jats:p>1. Despite highly potent immunosuppression regimens, there is a small cohort of patients at risk of graft failure due to rejection.<\/jats:p>\n            <jats:p>2. Steroid-resistant rejection is managed by the escalation of immunosuppression, but only one-third of patients with chronic rejection respond to this approach.<\/jats:p>\n            <jats:p>3. Interferon therapy for recurrent hepatitis C may induce an immunoreactive state and increase rejection rates.<\/jats:p>\n            <jats:p>4. Cyclosporine reduces the risk of recurrence of primary biliary cirrhosis but does not alter survival rates.<\/jats:p>\n            <jats:p>5. Patterns of primary sclerosing cholangitis recurrence are not affected by immunosuppression.<\/jats:p>\n            <jats:p>6. Autoimmune hepatitis recurrence and de novo autoimmune hepatitis are corticosteroid-responsive in most cases.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/lt.22413","type":"journal-article","created":{"date-parts":[[2011,8,17]],"date-time":"2011-08-17T18:49:45Z","timestamp":1313606985000},"page":"S29-S33","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":17,"title":["The immunoreactive patient: Rejection and autoimmune disease"],"prefix":"10.1097","volume":"17","author":[{"given":"John","family":"O'Grady","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-6-20250124","doi-asserted-by":"crossref","first-page":"971983","DOI":"10.1111\/j.1432-2277.2010.01143.x","article-title":"Current views on rejection pathology in liver transplantation.","volume":"23","author":"Neil","year":"2010","journal-title":"Transpl Int"},{"key":"R3-6-20250124","doi-asserted-by":"crossref","first-page":"502508","DOI":"10.1002\/lt.500050611","article-title":"Tacrolimus rescue in liver transplant recipients with refractory rejection or intolerance or malabsorption of cyclosporine. 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