{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T07:42:43Z","timestamp":1771918963906,"version":"3.50.1"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1370,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:sec>\n            <jats:title>Abstract<\/jats:title>\n            <jats:p>Living liver donation is a successful treatment for patients with end-stage liver disease. Most adults are provided with a right lobe graft to ensure a generous recipient liver volume. Some centers are re-exploring the use of smaller left lobe grafts to potentially reduce the donor risk. However, the evidence showing that the donor risk is lower with left lobe donation is inconsistent, and most previous studies have been limited by potential learning curve effects, small sample sizes, or poorly matched comparison groups. To address these deficiencies, we conducted a case-control study. Forty-five consecutive patients who underwent left hepatectomy (LH; n = 4) or left lateral segmentectomy (LLS; n = 41) were compared with matched controls who underwent right hepatectomy (RH) or extended right hepatectomy (ERH). The overall complication rates of the 3 groups were similar (31%-37%). There were no grade 4 or 5 complications. There were more grade 3 complications for the RH patients (13.3%) and the ERH patients (15.6%) versus the LH\/LLS patients (2.2%). The extent of the liver resection significantly correlated with the peak international normalized ratio (INR), the days to INR normalization, and the peak bilirubin level. A univariate analysis demonstrated that hepatectomy, the spared volume percentage, and the peak bilirubin level were strongly associated with grade 3 complications. A higher peak bilirubin level, which correlated with a lower residual liver volume, was associated with grade 3 complications in a multivariate analysis (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.005). RH and grade 3 complications were associated with an increased length of stay (&gt;7 days) in a multivariate analysis. In conclusion, this analysis demonstrates a significant correlation between the residual liver volume and liver dysfunction, serious adverse postoperative events, and longer hospital stays. Donor safety should be the first priority of all living liver donor programs. We propose that the surgical procedure removing the smallest amount of the liver required to provide adequate recipient graft function should become the standard of care for living liver donation. Liver Transpl, 2011. \u00a9 2011 AASLD.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/lt.22420","type":"journal-article","created":{"date-parts":[[2011,8,17]],"date-time":"2011-08-17T18:50:01Z","timestamp":1313607001000},"page":"1404-1411","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":45,"title":["Living Donor Hepatectomy: The Importance of the Residual Liver Volume"],"prefix":"10.1097","volume":"17","author":[{"given":"Trevor W.","family":"Reichman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charbel","family":"Sandroussi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solomon M.","family":"Azouz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lesley","family":"Adcock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark S.","family":"Cattral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian D.","family":"McGilvray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul D.","family":"Greig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anand","family":"Ghanekar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Selzner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Levy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Grant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-6-20250124","doi-asserted-by":"crossref","first-page":"589598","DOI":"10.1111\/j.1600-6143.2005.01220.x","article-title":"Improved survival after live donor adult liver transplantation (LDALT) using right lobe grafts: program experience and lessons learned.","volume":"6","author":"Pomposelli","year":"2006","journal-title":"Am J Transplant"},{"key":"R2-6-20250124","doi-asserted-by":"crossref","first-page":"149156","DOI":"10.1111\/j.1600-6143.2004.00654.x","article-title":"Adult living donor versus deceased donor liver transplantation: a 6year single center experience.","volume":"5","author":"Maluf","year":"2005","journal-title":"Am J Transplant"},{"key":"R3-6-20250124","doi-asserted-by":"crossref","first-page":"25692579","DOI":"10.1111\/j.1600-6143.2008.02440.x","article-title":"; for A2ALL Study Group. Recipient morbidity after living and deceased donor liver transplantation: findings from the A2ALL Retrospective Cohort Study.","volume":"8","author":"Freise","year":"2008","journal-title":"Am J Transplant"},{"key":"R4-6-20250124","doi-asserted-by":"crossref","first-page":"404410","DOI":"10.1097\/01.sla.0000201544.36473.a2","article-title":"Operative outcomes of adulttoadult right lobe live donor liver transplantation: a comparative study with cadaveric wholegraft liver transplantation in a single center.","volume":"243","author":"Liu","year":"2006","journal-title":"Ann Surg"},{"key":"R5-6-20250124","doi-asserted-by":"crossref","first-page":"9981002","DOI":"10.1111\/j.1600-6143.2006.01692.x","article-title":"Reduced mortality with rightlobe living donor compared to deceaseddonor liver transplantation when analyzed from the time of listing.","volume":"7","author":"Shah","year":"2007","journal-title":"Am J Transplant"},{"key":"R6-6-20250124","doi-asserted-by":"crossref","first-page":"364371","DOI":"10.1111\/j.1600-6143.2009.02950.x","article-title":"Adult living liver donors have excellent longterm medical outcomes: the University of Toronto liver transplant experience.","volume":"10","author":"Adcock","year":"2010","journal-title":"Am J Transplant"},{"key":"R7-6-20250124","doi-asserted-by":"crossref","first-page":"649657","DOI":"10.1002\/lt.22043","article-title":"Left lobe adulttoadult living donor liver transplantation: small grafts and hemiportocaval shunts in the prevention of smallforsize syndrome.","volume":"16","author":"Botha","year":"2010","journal-title":"Liver Transpl"},{"key":"R8-6-20250124","doi-asserted-by":"crossref","first-page":"110114","DOI":"10.1097\/TP.0b013e3181aaccb0","article-title":"; for Japanese Liver Transplantation Society. Donor complications associated with living donor liver transplantation in Japan.","volume":"88","author":"Hashikura","year":"2009","journal-title":"Transplantation"},{"key":"R9-6-20250124","doi-asserted-by":"crossref","first-page":"315325","DOI":"10.1097\/01.sla.0000236600.24667.a4","article-title":"Outcomes of adulttoadult living donor liver transplantation: a single institutions experience with 335 consecutive cases.","volume":"245","author":"Morioka","year":"2007","journal-title":"Ann Surg"},{"key":"R10-6-20250124","doi-asserted-by":"crossref","first-page":"9198","DOI":"10.1002\/lt.20987","article-title":"Effect of side and size of graft on surgical outcomes of adulttoadult live donor liver transplantation.","volume":"13","author":"Chan","year":"2007","journal-title":"Liver Transpl"},{"key":"R11-6-20250124","doi-asserted-by":"crossref","first-page":"780788","DOI":"10.1034\/j.1600-6143.2002.20813.x","article-title":"Analysis of donor risk in livingdonor hepatectomy: the impact of resection type on clinical outcome.","volume":"2","author":"Salame","year":"2002","journal-title":"Am J Transplant"},{"key":"R12-6-20250124","doi-asserted-by":"crossref","first-page":"17651767","DOI":"10.1097\/01.TP.0000129406.35825.6D","article-title":"Comparative analysis of live liver donation risk using a comprehensive grading system for severity.","volume":"77","author":"Salvalaggio","year":"2004","journal-title":"Transplantation"},{"key":"R13-6-20250124","doi-asserted-by":"crossref","first-page":"5862","DOI":"10.1053\/jlts.2002.29761","article-title":"Safe donor hepatectomy for living related liver transplantation.","volume":"8","author":"Sugawara","year":"2002","journal-title":"Liver Transpl"},{"key":"R14-6-20250124","doi-asserted-by":"crossref","first-page":"11741179","DOI":"10.1001\/archsurg.137.10.1174","article-title":"Characteristics of liver grafts in livingdonor adult liver transplantation: comparison between right and leftlobe grafts.","volume":"137","author":"Shimada","year":"2002","journal-title":"Arch Surg"},{"key":"R15-6-20250124","doi-asserted-by":"crossref","first-page":"751757","DOI":"10.1111\/j.1600-6143.2004.00405.x","article-title":"Livingdonor right hepatectomy with or without inclusion of middle hepatic vein: comparison of morbidity and outcome in 56 patients.","volume":"4","author":"Cattral","year":"2004","journal-title":"Am J Transplant"},{"key":"R16-6-20250124","doi-asserted-by":"crossref","first-page":"205213","DOI":"10.1097\/01.sla.0000133083.54934.ae","article-title":"Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey.","volume":"240","author":"Dindo","year":"2004","journal-title":"Ann Surg"},{"issue":"suppl","key":"R17-6-20250124","first-page":"S12S15","article-title":"Complications and longterm outcome of living liver donors: a survey of 1,508 cases in five Asian centers.","volume":"75","author":"Lo","year":"2003","journal-title":"Transplantation"},{"key":"R18-6-20250124","doi-asserted-by":"crossref","first-page":"11691178","DOI":"10.1111\/j.1600-6143.2009.02614.x","article-title":"Adult rightlobe living liver donors: quality of life, attitudes and predictors of donor outcomes.","volume":"9","author":"DuBay","year":"2009","journal-title":"Am J Transplant"},{"key":"R19-6-20250124","doi-asserted-by":"crossref","first-page":"20992104","DOI":"10.1111\/j.1600-6143.2010.03244.x","article-title":"Anonymous living liver donation: donor profiles and outcomes.","volume":"10","author":"Reichman","year":"2010","journal-title":"Am J Transplant"},{"key":"R20-6-20250124","doi-asserted-by":"crossref","first-page":"261269","DOI":"10.1097\/00000658-199709000-00005","article-title":"Adulttoadult living donor liver transplantation using extended right lobe grafts.","volume":"226","author":"Lo","year":"1997","journal-title":"Ann 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