{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T04:58:24Z","timestamp":1786251504638,"version":"build-2736575974"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1279,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,3]]},"abstract":"\n Abstract<\/jats:title>\n The platelet count (PC), the spleen size (SS), and the portal blood flow (PBF) have been independently studied in the perioperative period after orthotopic liver transplantation (OLT) for cirrhosis, but these parameters have not been described and analyzed in combination. We analyzed PC data and Doppler sonography measurements of SS and PBF from 125 adult patients before OLT and 1, 3, 6, 9, and 12 months after transplantation. A linear mixed model with fixed subject random intercepts was used. PCs increased significantly from 101.5 \u00b1 68.5 \u00d7 109<\/jats:sup>\/L before OLT to 162.4 \u00b1 86 \u00d7 109<\/jats:sup>\/L 1 month after OLT and remained stable for 1 year after the operation. PBF increased significantly from 619 \u00b1 239 mL\/minute before OLT to 1379 \u00b1 491 mL\/minute after OLT and remained stable during the first year. SS slowly decreased after OLT, but the decrease became significant only 9 months after the operation (13.8 \u00b1 4.2 cm before OLT versus 11.7 \u00b1 3.7 cm at 9 months, P<\/jats:italic> < 0.05). The cirrhosis etiology did not influence the evolution of the parameters. With or without replication or interferon treatment before OLT, the hepatitis C group viruses did not influence PCs postoperatively. The evolution of SS was correlated to the evolution of PCs in the year after transplantation. In conclusion, PCs and PBF increase rapidly after OLT, whereas SS slowly decreases. The cirrhosis etiology does not influence the evolution of PCs. Thrombocytopenia and splenomegaly are 2 results of portal hypertension, but the rapid normalization of PBF does not completely or rapidly reverse these 2 phenomena. \n Liver Transpl 18:340\u2013346, 2012.\n <\/jats:bold> \u00a9 2011 AASLD.<\/jats:bold>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/lt.22456","type":"journal-article","created":{"date-parts":[[2011,10,17]],"date-time":"2011-10-17T15:54:02Z","timestamp":1318866842000},"page":"340-346","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":23,"title":["Thrombocytopenia, Splenomegaly, and Portal Blood Flow in Patients Who Have Undergone Liver Transplantation for Cirrhosis"],"prefix":"10.1097","volume":"18","author":[{"given":"Daniel","family":"Eyraud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Granger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Ionescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Frat\u00e9a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Darnat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Christophe","family":"Vaillant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Michel","family":"Siksik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Hannoun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Coriat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-12-20250124","doi-asserted-by":"crossref","first-page":"923931","DOI":"10.1002\/lt.21510","article-title":"Platelets in liver transplantation: friend or foe?","volume":"14","author":"Pereboom","year":"2008","journal-title":"Liver Transpl"},{"key":"R2-12-20250124","doi-asserted-by":"crossref","first-page":"23312333","DOI":"10.1016\/j.transproceed.2004.07.001","article-title":"Persistent thrombocytopenia in liver transplant patients.","volume":"36","author":"Sutedja","year":"2004","journal-title":"Transplant Proc"},{"key":"R3-12-20250124","first-page":"1622","article-title":"Thrombocytopenia post liver transplantation. Correlations with preoperative platelet count, blood transfusion requirements, allograft function and outcome.","volume":"16","author":"McCaughan","year":"1992","journal-title":"J Hepatol"},{"key":"R4-12-20250124","first-page":"17101711","article-title":"Postliver transplantation thrombocytopenia: a persistent immunologic sequestration?","volume":"27","author":"Randoux","year":"1995","journal-title":"Transplant Proc"},{"key":"R5-12-20250124","doi-asserted-by":"crossref","first-page":"315321","DOI":"10.1046\/j.1365-2141.1997.2363056.x","article-title":"Thrombocytopenia following liver transplantation is associated with platelet consumption and thrombin generation.","volume":"98","author":"Richards","year":"1997","journal-title":"Br J Haematol"},{"key":"R6-12-20250124","doi-asserted-by":"crossref","first-page":"5864","DOI":"10.1002\/hep.510300112","article-title":"Systemic and splanchnic hemodynamic changes after liver transplantation for cirrhosis: a longterm prospective study.","volume":"30","author":"Piscaglia","year":"1999","journal-title":"Hepatology"},{"key":"R7-12-20250124","doi-asserted-by":"crossref","first-page":"175178","DOI":"10.1002\/hep.1840170202","article-title":"Persistence of systemic and splanchnic hyperkinetic circulation in liver transplant patients.","volume":"17","author":"Hadengue","year":"1993","journal-title":"Hepatology"},{"key":"R8-12-20250124","doi-asserted-by":"crossref","first-page":"355360","DOI":"10.1002\/hep.1840170302","article-title":"Hemodynamic and humoral changes after liver transplantation in patients with cirrhosis.","volume":"17","author":"Navasa","year":"1993","journal-title":"Hepatology"},{"key":"R9-12-20250124","doi-asserted-by":"crossref","first-page":"258262","DOI":"10.1002\/hep.1840150214","article-title":"High cardiac output of advanced liver disease persists after orthotopic liver transplantation.","volume":"15","author":"Henderson","year":"1992","journal-title":"Hepatology"},{"key":"R10-12-20250124","doi-asserted-by":"crossref","first-page":"601608","DOI":"10.1053\/jhep.2002.31352","article-title":"Change in portal flow after liver transplantation: effect on hepatic arterial resistance indices and role of spleen size.","volume":"35","author":"Bolognesi","year":"2002","journal-title":"Hepatology"},{"key":"R11-12-20250124","first-page":"147155","article-title":"Diagnostic value of Doppler assessment of the hepatic and portal vessels and ultrasound of the spleen in liver disease.","volume":"16","author":"ODonohue","year":"2004","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"R12-12-20250124","doi-asserted-by":"crossref","first-page":"119121","DOI":"10.2214\/ajr.157.1.2048509","article-title":"Normal splenic size in infants and children: sonographic measurements.","volume":"157","author":"Rosenberg","year":"1991","journal-title":"AJR Am J Roentgenol"},{"key":"R13-12-20250124","doi-asserted-by":"crossref","first-page":"573577","DOI":"10.1259\/bjr.75.895.750573","article-title":"Spleen size: how well do linear ultrasound measurements correlate with threedimensional CT volume assessments?","volume":"75","author":"Lamb","year":"2002","journal-title":"Br J Radiol"},{"key":"R14-12-20250124","doi-asserted-by":"crossref","first-page":"807813","DOI":"10.1097\/00007890-199304000-00024","article-title":"Risk factors for primary dysfunction after liver transplantationa multivariate analysis.","volume":"55","author":"Ploeg","year":"1993","journal-title":"Transplantation"},{"key":"R15-12-20250124","doi-asserted-by":"crossref","first-page":"646649","DOI":"10.1002\/bjs.1800600817","article-title":"Transection of the oesophagus for bleeding oesophageal varices.","volume":"60","author":"Pugh","year":"1973","journal-title":"Br J Surg"},{"key":"R16-12-20250124","doi-asserted-by":"crossref","first-page":"286301","DOI":"10.1002\/bimj.200510192","article-title":"Estimating correlation coefficient between two variables with repeated observations using mixed effects model.","volume":"48","author":"Roy","year":"2006","journal-title":"Biom J"},{"key":"R17-12-20250124","first-page":"507511","article-title":"Changes of splanchnic circulation with progression of chronic liver disease studied by echoDoppler flowmetry.","volume":"82","author":"Ohnishi","year":"1987","journal-title":"Am J Gastroenterol"},{"key":"R18-12-20250124","doi-asserted-by":"crossref","first-page":"6368","DOI":"10.1159\/000198095","article-title":"Spleen size and portal hypertension in cirrhosis.","volume":"17","author":"Westaby","year":"1978","journal-title":"Digestion"},{"key":"R19-12-20250124","first-page":"408410","article-title":"Relevance of reduced portal flow velocity, low platelet count and enlarged spleen diameter in the noninvasive diagnosis of compensated liver cirrhosis.","volume":"2","author":"Cioni","year":"1993","journal-title":"Eur J Med"},{"key":"R20-12-20250124","doi-asserted-by":"crossref","first-page":"7075","DOI":"10.1097\/00007890-200001150-00014","article-title":"Thrombocytopenia in liver transplant recipients: predictors, impact on fungal infections, and role of endogenous thrombopoietin.","volume":"69","author":"Chang","year":"2000","journal-title":"Transplantation"},{"key":"R21-12-20250124","doi-asserted-by":"crossref","first-page":"285288","DOI":"10.7326\/0003-4819-127-4-199708150-00005","article-title":"Thrombopoietin levels in patients with cirrhosis before and after orthotopic liver transplantation.","volume":"127","author":"Martin","year":"1997","journal-title":"Ann Intern Med"},{"key":"R22-12-20250124","first-page":"151156","article-title":"Thrombopoietic cytokines and reversal of thrombocytopenia after liver transplantation.","volume":"11","author":"PeckRadosavljevic","year":"1999","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"R23-12-20250124","doi-asserted-by":"crossref","first-page":"754758","DOI":"10.1136\/gut.44.5.754","article-title":"Thrombopoietin concentrations are low in patients with cirrhosis and thrombocytopenia and are restored after orthotopic liver transplantation.","volume":"44","author":"Goulis","year":"1999","journal-title":"Gut"},{"key":"R24-12-20250124","doi-asserted-by":"crossref","first-page":"351354","DOI":"10.1111\/j.1600-0609.1972.tb00952.x","article-title":"The relationship between splenic platelet pool and spleen size.","volume":"9","author":"Kutti","year":"1972","journal-title":"Scand J Haematol"},{"key":"R25-12-20250124","doi-asserted-by":"crossref","first-page":"181185","DOI":"10.1111\/j.1365-2141.1987.00187.x","article-title":"Splenic blood flow and intrasplenic platelet kinetics in relation to spleen volume.","volume":"67","author":"Wadenvik","year":"1987","journal-title":"Br J Haematol"},{"key":"R26-12-20250124","doi-asserted-by":"crossref","first-page":"135140","DOI":"10.1016\/S0168-8278(96)80021-3","article-title":"Thrombocytopenia associated with hepatitis C viral infection.","volume":"24","author":"Nagamine","year":"1996","journal-title":"J Hepatol"},{"key":"R27-12-20250124","doi-asserted-by":"crossref","first-page":"118124","DOI":"10.1111\/j.1600-6143.2004.00648.x","article-title":"Applicability, tolerability and efficacy of preemptive antiviral therapy in hepatitis Cinfected patients undergoing liver transplantation.","volume":"5","author":"Shergill","year":"2005","journal-title":"Am J Transplant"},{"key":"R28-12-20250124","doi-asserted-by":"crossref","first-page":"42284230","DOI":"10.1182\/blood.V99.11.4228","article-title":"Measurement of spleen volume by ultrasound scanning in patients with thrombocytosis: a prospective study.","volume":"99","author":"Picardi","year":"2002","journal-title":"Blood"},{"key":"R29-12-20250124","doi-asserted-by":"crossref","first-page":"626628","DOI":"10.1053\/jlts.2003.50081","article-title":"Portal hyperperfusion injury as the cause of primary nonfunction in a smallforsize liver graftsuccessful treatment with splenic artery ligation.","volume":"9","author":"Lo","year":"2003","journal-title":"Liver Transpl"},{"key":"R30-12-20250124","doi-asserted-by":"crossref","first-page":"208215","DOI":"10.1002\/lt.21663","article-title":"Significant correlation between spleen volume and thrombocytopenia in liver transplant patients: a concept for predicting persistent thrombocytopenia.","volume":"15","author":"Ohira","year":"2009","journal-title":"Liver Transpl"},{"key":"R31-12-20250124","doi-asserted-by":"crossref","first-page":"67876791","DOI":"10.3748\/wjg.v11.i43.6787","article-title":"Changes of duplex parameters and splenic size in liver transplant recipients during a long period of observation.","volume":"11","author":"Boozari","year":"2005","journal-title":"World J Gastroenterol"},{"key":"R32-12-20250124","doi-asserted-by":"crossref","first-page":"57235729","DOI":"10.3748\/wjg.14.5723","article-title":"Severe thrombocytopenia before liver transplantation is associated with delayed recovery of thrombocytopenia regardless of donor type.","volume":"14","author":"Chang","year":"2008","journal-title":"World J Gastroenterol"},{"key":"R33-12-20250124","doi-asserted-by":"crossref","first-page":"29062907","DOI":"10.1016\/S0041-1345(99)00610-7","article-title":"Is splenic artery ligation effective for thrombocytopenia early after liver transplantation?","volume":"31","author":"Matsukura","year":"1999","journal-title":"Transplant Proc"},{"key":"R34-12-20250124","doi-asserted-by":"crossref","first-page":"10541058","DOI":"10.1001\/archsurg.142.11.1054","article-title":"Impact of graft size on postoperative thrombocytopenia in living donor liver transplant.","volume":"142","author":"Marubashi","year":"2007","journal-title":"Arch Surg"},{"key":"R35-12-20250124","doi-asserted-by":"crossref","first-page":"320326","DOI":"10.1007\/s00268-009-0314-x","article-title":"Effect of liver transplantation on spleen size, collateral veins, and platelet counts.","volume":"34","author":"Chikamori","year":"2010","journal-title":"World J Surg"},{"key":"R36-12-20250124","first-page":"441452","article-title":"Splenic blood flow in cirrhosis and portal hypertension.","volume":"34","author":"Williams","year":"1968","journal-title":"Clin Sci"},{"key":"R37-12-20250124","doi-asserted-by":"crossref","first-page":"342348","DOI":"10.1002\/hep.1840200212","article-title":"The effect of splenomegaly on splanchnic hemodynamics in nonalcoholic cirrhosis after distal splenorenal shunt and splenopancreatic disconnection.","volume":"20","author":"Takagi","year":"1994","journal-title":"Hepatology"},{"key":"R38-12-20250124","doi-asserted-by":"crossref","first-page":"208213","DOI":"10.1016\/S0016-5085(19)33762-X","article-title":"Splenic blood flow and resistance in patients with cirrhosis before and after portacaval anastomoses.","volume":"59","author":"Gitlin","year":"1970","journal-title":"Gastroenterology"},{"key":"R39-12-20250124","doi-asserted-by":"crossref","first-page":"458465","DOI":"10.1002\/hep.1840220214","article-title":"Hemodynamics after orthotopic liver transplantation: study of associated factors and longterm effects.","volume":"22","author":"Gadano","year":"1995","journal-title":"Hepatology"},{"key":"R40-12-20250124","doi-asserted-by":"crossref","first-page":"10431049","DOI":"10.1002\/lt.21797","article-title":"Role of splanchnic hemodynamics in liver regeneration after living donor liver transplantation.","volume":"15","author":"Jiang","year":"2009","journal-title":"Liver Transpl"}],"container-title":["Liver Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flt.22456","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01445473-201203000-00012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T17:12:16Z","timestamp":1737738736000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01445473-201203000-00012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1002\/lt.22456","relation":{},"ISSN":["1527-6465"],"issn-type":[{"value":"1527-6465","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3]]}}}