{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T09:33:58Z","timestamp":1768556038427,"version":"3.49.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1065,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Liver transplantation (LT) is the treatment of choice for hepatorenal syndrome (HRS). However, the clinical benefits of living donor liver transplantation (LDLT) are not yet well established. We, therefore, investigated the outcomes of patients with HRS who underwent LDLT and patients with HRS who received transplants from deceased donors. This study focused on 71 patients with HRS out of a total of 726 consecutive adult Korean patients who underwent LT at a single Asian center. We compared 48 patients who underwent LDLT with 23 patients who underwent deceased donor liver transplantation (DDLT). Patients with HRS showed poorer survival than patients without HRS (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.01). Poorer survival was associated with higher in-hospital mortality for patients with HRS (18.3% versus 5.2%, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001). In comparison with DDLT, LDLT was associated with younger donors and shorter ischemic times. The survival rate with LDLT was significantly higher than the survival rate with DDLT (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.02). Among patients with high Model for End-Stage Liver Disease scores (\u226530) or type 1 HRS, the survival rates for the LDLT group were not inferior to those for the DDLT group. LDLT significantly improved recipient survival after adjustments for several risk factors (hazard ratio = 0.20, 95% confidence interval = 0.05-0.85, <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.03). Kidney function was significantly improved after LT, and there was no difference between LDLT and DDLT. No patients in the HRS cohort required maintenance renal replacement therapy. In conclusion, LDLT may be a beneficial option for patients with HRS. Liver Transpl 18:1237\u20131244, 2012. \u00a9 2012 AASLD.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/lt.23493","type":"journal-article","created":{"date-parts":[[2012,6,19]],"date-time":"2012-06-19T17:58:48Z","timestamp":1340128728000},"page":"1237-1243","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":30,"title":["Clinical outcomes of patients with hepatorenal syndrome after living donor liver transplantation"],"prefix":"10.1097","volume":"18","author":[{"given":"Jung Pyo","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyuk Yong","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji In","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nam-Joon","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung-Suk","family":"Suh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hae Won","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myounghee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun Kyu","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun Soo","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yon Su","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-15-20250124","first-page":"13101318","article-title":"Diagnosis, prevention and treatment of hepatorenal syndrome in cirrhosis.","volume":"56","author":"Salerno","year":"2007","journal-title":"Gut"},{"key":"R2-15-20250124","doi-asserted-by":"crossref","first-page":"428430","DOI":"10.1097\/00007890-199102000-00030","article-title":"Longterm survival and renal function following liver transplantation in patients with and without hepatorenal syndromeexperience in 300 patients.","volume":"51","author":"Gonwa","year":"1991","journal-title":"Transplantation"},{"key":"R3-15-20250124","doi-asserted-by":"crossref","first-page":"361365","DOI":"10.1097\/00007890-199502150-00010","article-title":"Impact of pretransplant renal function on survival after liver transplantation.","volume":"59","author":"Gonwa","year":"1995","journal-title":"Transplantation"},{"key":"R4-15-20250124","doi-asserted-by":"crossref","first-page":"838843","DOI":"10.1002\/lt.21149","article-title":"Hepatorenal syndrome: a proposal for kidney after liver transplantation (KALT).","volume":"13","author":"Ruiz","year":"2007","journal-title":"Liver Transpl"},{"key":"R5-15-20250124","doi-asserted-by":"crossref","first-page":"11551159","DOI":"10.1056\/NEJM197311292892201","article-title":"Recovery from hepatorenal syndrome after orthotopic liver transplantation.","volume":"289","author":"Iwatsuki","year":"1973","journal-title":"N Engl J Med"},{"key":"R7-15-20250124","doi-asserted-by":"crossref","first-page":"415419","DOI":"10.1097\/00000658-198704000-00012","article-title":"The reversal of the hepatorenal syndrome in four pediatric patients following successful orthotopic liver transplantation.","volume":"205","author":"Wood","year":"1987","journal-title":"Ann Surg"},{"key":"R8-15-20250124","doi-asserted-by":"crossref","first-page":"910915","DOI":"10.1053\/jlts.2002.35665","article-title":"Safety of right lobectomy in living donor liver transplantation.","volume":"8","author":"Suh","year":"2002","journal-title":"Liver Transpl"},{"key":"R9-15-20250124","doi-asserted-by":"crossref","first-page":"797806","DOI":"10.1002\/lt.21030","article-title":"Threequarters of right liver donors experienced postoperative complications.","volume":"13","author":"Yi","year":"2007","journal-title":"Liver Transpl"},{"key":"R10-15-20250124","doi-asserted-by":"crossref","first-page":"496503","DOI":"10.1002\/lt.21606","article-title":"Improved outcome of adult recipients with a high Model for EndStage Liver Disease score and a smallforsize graft.","volume":"15","author":"Yi","year":"2009","journal-title":"Liver Transpl"},{"key":"R12-15-20250124","first-page":"164176","article-title":"Definition and diagnostic criteria of refractory ascites and hepatorenal syndrome in cirrhosis. 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