{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T07:16:08Z","timestamp":1773731768902,"version":"3.50.1"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","license":[{"start":{"date-parts":[[2012,12,7]],"date-time":"2012-12-07T00:00:00Z","timestamp":1354838400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"National Institutes of Health Genomics of Transplantation"},{"name":"American Recovery and Reinvestment Act","award":["5U19-AI070119"],"award-info":[{"award-number":["5U19-AI070119"]}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>There have been many reports showing significant associations between recipient genetic variants and allograft outcomes, including acute rejection and graft failure, but less is known about the contribution of the donor genotype. We analyzed 37 single-nucleotide polymorphisms (SNPs) within the toll-like receptor 4 (TLR4) gene from deceased donor liver allografts transplanted into 738 recipients to determine their effects on liver graft failure (LGF). Two SNPs exhibited a significant association with LGF after adjustments for donor race and recipient race and corrections for multiple test comparisons: rs11536865 [hazard ratio (HR) = 2.5, <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.0003] and rs5030717 (HR = 1.67, <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.0008). An additional SNP, rs913930, exhibited a significant association in Caucasian donors (HR = 1.62, <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.0006), and 2 SNPs exhibited a suggestive association in African American donors: rs11536865 (HR = 2.45, <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.002) and rs5030717 (HR = 2.32, <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.002). Additionally, the liver donor risk index (HR = 2.56, 95% confidence interval = 1.54-4.26, <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.0003) and the recipient hepatitis C virus (HCV) status (HR = 1.53, 95% confidence interval = 1.04-2.24, <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.032) increased the risk of all-cause LGF in a Cox proportional hazards model adjusted for recipient race. Donor polymorphisms in TLR4 could be important factors in modulating TLR4 activity and, therefore, affect the risk of graft loss. Additionally, there is a suggestion of an interaction between polymorphisms within TLR4 and the HCV status. Liver Transpl, 2012. \u00a9 2012 AASLD.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/lt.23549","type":"journal-article","created":{"date-parts":[[2012,9,15]],"date-time":"2012-09-15T11:32:23Z","timestamp":1347708743000},"page":"1399-1405","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":24,"title":["Donor polymorphisms of toll-like receptor 4 associated with graft failure in liver transplant recipients"],"prefix":"10.1097","volume":"18","author":[{"given":"William S.","family":"Oetting","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihua","family":"Guan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David P.","family":"Schladt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert 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K.","family":"Israni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-1-20250124","doi-asserted-by":"crossref","first-page":"905916","DOI":"10.1038\/clpt.2011.346","article-title":"Human pregnane X receptor genotype of the donor but not of the recipient is a risk factor for delayed graft function after renal transplantation.","volume":"91","author":"Hauser","year":"2012","journal-title":"Clin Pharmacol Ther"},{"key":"R2-1-20250124","doi-asserted-by":"crossref","first-page":"12171224","DOI":"10.1002\/lt.21834","article-title":"Donor mannosebinding lectin gene polymorphisms influence the outcome of liver transplantation.","volume":"15","author":"Cervera","year":"2009","journal-title":"Liver Transpl"},{"key":"R3-1-20250124","doi-asserted-by":"crossref","first-page":"377385","DOI":"10.1111\/j.1600-6143.2007.02048.x","article-title":"Heme oxygenase1 genotype of the donor is associated with graft survival 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