{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:55:05Z","timestamp":1777510505308,"version":"3.51.4"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2013,3,11]],"date-time":"2013-03-11T00:00:00Z","timestamp":1362960000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Portal vein thrombosis (PVT) occurs in \u226412% of pediatric recipients of liver transplantation (LT). Known complications of PVT include portal hypertension, allograft loss, and mortality. The management of PVT is varied. A single-center, case-control study of pediatric LT recipients with portal vein (PV) changes after LT was performed. Cases were categorized as early PVT (if PVT was detected within 30 days of transplantation) or late PVT (if PVT was detected more than 30 days after transplantation or if early PVT persisted beyond 30 days). Two non-PVT control patients were matched on the basis of the recipient weight, transplant indication, and allograft type to each patient with PVT. Thirty-two of the 415 LT recipients (7.7%) received 37 allografts and developed PVT. In comparison with control patients, a higher proportion of patients with PVT had PVT present before LT (13.3% versus 0%, <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.01). Patients with early PVT usually returned to the operating room, and 9 of 15 patients (60%) had PV flow restored. Patients with late PVT had lower white blood cell (4.9 [1000\/\u03bcL] versus 6.8 [1000\/\u03bcL], <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.01) and platelet counts (140 [1000\/\u03bcL] versus 259 [1000\/\u03bcL], <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.01), an elevated international normalized ratio (1.2 versus 1.0, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001), and more gastrointestinal bleeding (25% versus 8.3%, <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.03) compared to controls. Patients with PVT were also less frequently at the expected grade level (52% versus 88%, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001). The patient survival rates were 84%, 78%, and 78% and 91%, 84%, and 79% for cases and controls at 1, 5, and 10 years, respectively. The allograft survival rates were 90%, 80%, and 80% for cases and 94%, 89%, and 87% for controls at 1, 5, and 10 years, respectively. In conclusion, patients with early and late PVT had preserved allograft function, and there was no impact on mortality. Patients diagnosed with early PVT often underwent operative interventions with successful restoration of flow. Patients diagnosed with late PVT experienced variceal bleeding, and some required portosystemic shunting procedures. Academic delays were also more common. In late PVT, the clinical presentation dictates care because the optimal management algorithm has not yet been determined. Multi-institutional studies are needed to confirm these findings and improve patient outcomes.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/lt.23583","type":"journal-article","created":{"date-parts":[[2013,3,13]],"date-time":"2013-03-13T22:15:07Z","timestamp":1363212907000},"page":"315-321","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":46,"title":["Management and long-term consequences of portal vein thrombosis after liver transplantation in children"],"prefix":"10.1097","volume":"19","author":[{"given":"Kyle M.","family":"Jensen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen M.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria H.","family":"Alonso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaimie D.","family":"Nathan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick C.","family":"Ryckman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greg M.","family":"Tiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R2-11-20250124","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1097\/00000658-200211000-00017","article-title":"Longterm venous complications after fullsize and segmental pediatric liver transplantation.","volume":"236","author":"Buell","year":"2002","journal-title":"Ann Surg"},{"key":"R3-11-20250124","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.transproceed.2010.02.059","article-title":"Risk factors for portal vein complications after pediatric living donor liver transplantation with leftsided grafts.","volume":"42","author":"Moon","year":"2010","journal-title":"Transplant Proc"},{"key":"R4-11-20250124","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.surg.2010.04.018","article-title":"Portal vein thrombosis in biliary atresia patients after living donor liver transplantation.","volume":"149","author":"Ou","year":"2011","journal-title":"Surgery"},{"key":"R5-11-20250124","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1111\/j.1600-6143.2008.02360.x","article-title":"Portal vein complications in pediatric living donor liver transplantation using leftside grafts.","volume":"8","author":"Ueda","year":"2008","journal-title":"Am J Transplant"},{"key":"R6-11-20250124","first-page":"34","article-title":"Liver transplant recipients with portal vein thrombosis: a single center retrospective study.","volume":"8","author":"Tao","year":"2009","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"R7-11-20250124","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/lt.500030401","article-title":"Portal vein complications after liver transplantation for biliary atresia.","volume":"3","author":"Chardot","year":"1997","journal-title":"Liver Transpl Surg"},{"key":"R8-11-20250124","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1007\/s00383-009-2430-y","article-title":"Surgical complications after living donor liver transplantation in patients with biliary atresia: a relatively high incidence of portal vein complications.","volume":"25","author":"Takahashi","year":"2009","journal-title":"Pediatr Surg Int"},{"key":"R9-11-20250124","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/S0140-6736(88)92597-4","article-title":"Protein C deficiency and portal thrombosis in liver transplantation in children.","volume":"2","author":"Harper","year":"1988","journal-title":"Lancet"},{"key":"R10-11-20250124","doi-asserted-by":"crossref","first-page":"165","DOI":"10.2223\/JPED.969","article-title":"Thrombophilic disorders in children and adolescents with portal vein thrombosis in Portuguese.","volume":"79","author":"Pinto","year":"2003","journal-title":"J Pediatr (Rio J)"},{"key":"R12-11-20250124","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.jhep.2009.12.012","article-title":"Encephalopathy assessment in children with extrahepatic portal vein obstruction with MR, psychometry and critical flicker frequency.","volume":"52","author":"Yadav","year":"2010","journal-title":"J Hepatol"},{"key":"R13-11-20250124","first-page":"1008","article-title":"Late onset portal vein thrombosis and its risk factors.","volume":"55","author":"Kishi","year":"2008","journal-title":"Hepatogastroenterology"},{"key":"R14-11-20250124","doi-asserted-by":"crossref","first-page":"e405","DOI":"10.1542\/peds.2005-1177","article-title":"Surgically restoring portal blood flow to the liver in children with primary extrahepatic portal vein thrombosis improves fluid neurocognitive ability.","volume":"117","author":"Mack","year":"2006","journal-title":"Pediatrics"},{"key":"R15-11-20250124","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1097\/01.sla.0000205827.73706.97","article-title":"Correction of extrahepatic portal vein thrombosis by the mesenteric to left portal vein bypass.","volume":"243","author":"Superina","year":"2006","journal-title":"Ann Surg"},{"key":"R17-11-20250124","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.3748\/wjg.14.2377","article-title":"Changes in count and function of splenic lymphocytes from patients with portal hypertension.","volume":"14","author":"Li","year":"2008","journal-title":"World J Gastroenterol"},{"key":"R18-11-20250124","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.cgh.2011.09.010","article-title":"Hypercoagulability in patients with chronic noncirrhotic portal vein thrombosis.","volume":"10","author":"Raffa","year":"2012","journal-title":"Clin Gastroenterol Hepatol"},{"key":"R19-11-20250124","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1002\/lt.22371","article-title":"Portal vein thrombosis and outcomes for pediatric liver transplant candidates and recipients in the United States.","volume":"17","author":"Waits","year":"2011","journal-title":"Liver Transpl"},{"key":"R20-11-20250124","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1111\/j.1399-3046.2009.01259.x","article-title":"Incidence, impact, and treatment of portal and hepatic venous complications following pediatric liver transplantation: a singlecenter 12 year experience.","volume":"14","author":"Heffron","year":"2010","journal-title":"Pediatr Transplant"},{"key":"R21-11-20250124","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.jamcollsurg.2008.12.032","article-title":"Vascular complications of orthotopic liver transplantation: experience in more than 4,200 patients.","volume":"208","author":"Duffy","year":"2009","journal-title":"J Am Coll Surg"},{"key":"R22-11-20250124","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.transproceed.2005.01.044","article-title":"Portal vein complications in the longterm course after pediatric living donor liver transplantation.","volume":"37","author":"Ueda","year":"2005","journal-title":"Transplant Proc"}],"container-title":["Liver Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flt.23583","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flt.23583","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01445473-201303000-00011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T17:18:36Z","timestamp":1737739116000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01445473-201303000-00011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1002\/lt.23583","relation":{},"ISSN":["1527-6465"],"issn-type":[{"value":"1527-6465","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}