{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T01:14:08Z","timestamp":1779153248330,"version":"3.51.4"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2013,4,9]],"date-time":"2013-04-09T00:00:00Z","timestamp":1365465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Early allograft dysfunction (EAD) is a serious complication after liver transplantation (LT). There is no uniform definition of EAD, and most definitions are based on arbitrary laboratory values. The aim of this study was to devise a definition of EAD that maximizes the predictive power for early death and graft failure. In this single-center, retrospective study, the ability of the international normalized ratio (INR), total bilirubin, aspartate aminotransferase (AST), physiological Model for End-Stage Liver Disease (MELD) score, and serum albumin levels within 7 days after LT to predict 90-day mortality or graft loss was compared with 2 previously used definitions of EAD: (1) peak total bilirubin level &gt;10 mg\/dL on days 2 to 7 and (2) either a total bilirubin level &gt;10 mg\/dL or an INR &gt;1.6 on day 7 or an AST or alanine aminotransferase level &gt;2000 IU\/L within the first 7 days. Of 572 enrolled LT patients 38 died or required retransplantation within 90 days. Peak INR, total bilirubin level, AST levels, and MELD scores were predictors of 90-day graft failure. MELD score on postoperative day 5 was the best predictor with an area under the curve of the receiver operating characteristic curve of 0.812 (95% CI: 0.739-0.886, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001). The best cutoff of MELD score on day 5 for predicting 90-day mortality or graft loss was 18.9. A MELD score &gt;18.9 on postoperative day 5 was a better predictor than any other laboratory value or definition of EAD. This study has demonstrated that the MELD score can be a useful tool not only for pretransplant graft allocation but also for postoperative risk stratification. <jats:italic toggle=\"yes\">Liver Transpl 19:534\u2013542, 2013<\/jats:italic>. \u00a9 2013 AASLD.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/lt.23634","type":"journal-article","created":{"date-parts":[[2013,3,6]],"date-time":"2013-03-06T05:55:33Z","timestamp":1362549333000},"page":"534-542","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":57,"title":["Predicting early allograft failure and mortality after liver transplantation"],"prefix":"10.1097","volume":"19","author":[{"given":"Gebhard","family":"Wagener","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Raffel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew T.","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moury","family":"Minhaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Emond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-9-20250124","doi-asserted-by":"crossref","first-page":"807813","DOI":"10.1097\/00007890-199304000-00024","article-title":"Risk factors for primary dysfunction after liver transplantationa multivariate analysis.","volume":"55","author":"Ploeg","year":"1993","journal-title":"Transplantation"},{"key":"R2-9-20250124","doi-asserted-by":"crossref","first-page":"20872090","DOI":"10.1016\/S0041-1345(99)00270-5","article-title":"Risk factors for primary dysfunction after liver transplantation in the University of Wisconsin solution era.","volume":"31","author":"Brokelman","year":"1999","journal-title":"Transplant Proc"},{"key":"R3-9-20250124","first-page":"899904","article-title":"Causes of early mortality after liver transplantation: a twentyyears single centre experience in French.","volume":"30","author":"Jung","year":"2011","journal-title":"Ann Fr Anesth Reanim"},{"key":"R4-9-20250124","doi-asserted-by":"crossref","first-page":"14851487","DOI":"10.1016\/j.transproceed.2008.01.076","article-title":"A singlecenter experience of retransplantation for liver transplant recipients with a failing graft.","volume":"40","author":"Chen","year":"2008","journal-title":"Transplant Proc"},{"key":"R5-9-20250124","doi-asserted-by":"crossref","first-page":"11101113","DOI":"10.1016\/j.transproceed.2011.01.141","article-title":"Risk factors in liver retransplantation: a singlecenter experience.","volume":"43","author":"Crivellin","year":"2011","journal-title":"Transplant Proc"},{"key":"R6-9-20250124","first-page":"180184","article-title":"Liver retransplantation: report of 80 cases and review of literature.","volume":"5","author":"Shen","year":"2006","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"R7-9-20250124","first-page":"302310","article-title":"Early allograft dysfunction after liver transplantation: a definition and predictors of outcome. National Institute of Diabetes and Digestive and Kidney Diseases Liver Transplantation Database.","volume":"66","author":"Deschenes","year":"1998","journal-title":"Transplantation"},{"key":"R8-9-20250124","doi-asserted-by":"crossref","first-page":"943949","DOI":"10.1002\/lt.22091","article-title":"Validation of a current definition of early allograft dysfunction in liver transplant recipients and analysis of risk factors.","volume":"16","author":"Olthoff","year":"2010","journal-title":"Liver Transpl"},{"key":"R9-9-20250124","doi-asserted-by":"crossref","first-page":"10231032","DOI":"10.1111\/j.1432-2277.2010.01089.x","article-title":"How to define initial poor graft function after liver transplantation? a new functional definition by the LiMAx test.","volume":"23","author":"Stockmann","year":"2010","journal-title":"Transpl Int"},{"key":"R10-9-20250124","doi-asserted-by":"crossref","first-page":"816824","DOI":"10.1111\/j.1478-3231.2007.01494.x","article-title":"A novel prognostic model based on serum levels of total bilirubin and creatinine early after liver transplantation.","volume":"27","author":"Xu","year":"2007","journal-title":"Liver Int"},{"key":"R11-9-20250124","doi-asserted-by":"crossref","first-page":"464470","DOI":"10.1053\/jhep.2001.22172","article-title":"A model to predict survival in patients with endstage liver disease.","volume":"33","author":"Kamath","year":"2001","journal-title":"Hepatology"},{"key":"R12-9-20250124","first-page":"602605","article-title":"Standardizing the prothrombin time. 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When 1 plus 1 doesnt make 2.","volume":"166","author":"Wolfe","year":"2002","journal-title":"CMAJ"}],"container-title":["Liver Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flt.23634","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flt.23634","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01445473-201305000-00009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T17:26:19Z","timestamp":1737739579000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01445473-201305000-00009"}},"subtitle":["The role of the postoperative model for end-stage liver disease score"],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1002\/lt.23634","relation":{},"ISSN":["1527-6465"],"issn-type":[{"value":"1527-6465","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]}}}