{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T10:47:54Z","timestamp":1792838874347,"version":"4.5.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2013,8,18]],"date-time":"2013-08-18T00:00:00Z","timestamp":1376784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Functional outcomes for long-term survivors of acute liver failure (ALF) are not well characterized. The aim of this prospective study was to determine health-related quality of life in long-term adult ALF survivors. Acute Liver Failure Study Group registry participants completed the Centers for Disease Control and Prevention Health-Related Quality of Life 14 and Short Form 36 (SF-36) questionnaires at 1- and\/or 2-year follow-up study visits. Responses were compared among ALF subgroups and to those for available general US population controls. Among the 282 adult ALF patients, 125 had undergone liver transplantation (LT), whereas 157, including 95 acetaminophen overdose (APAP) patients and 62 non-APAP patients, were spontaneous survivors (SSs). APAP SS patients reported significantly lower general health scores and more days of impaired mental and physical health, activity limitations due to poor health, pain, depression, and anxiety in comparison with the other groups (<jats:italic toggle=\"yes\">P<\/jats:italic> \u2264 0.001). There were no significant differences in coma grade or in the use of mechanical ventilation or intracranial pressure monitoring among the patient groups during their ALF hospitalization, but APAP SSs had significantly higher rates of psychiatric disease and substance abuse (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001). In comparison with the general US population, a greater proportion of the combined SS patients reported fair or poor health and \u226514 days of impaired physical\/mental health and activity limitations due to poor health. In addition, a greater proportion of LT recipients reported \u226514 days of impaired physical\/mental health. Similar results were observed with the SF-36 across the 3 ALF subgroups and in comparison with population controls. In conclusion, long-term adult survivors of ALF reported significantly lower quality of life scores than US population controls. Furthermore, APAP SS patients reported the lowest quality of life scores, possibly because of higher rates of premorbid psychiatric and substance abuse disorders. <jats:italic toggle=\"yes\">Liver Transpl 19:991\u20131000, 2013<\/jats:italic>. \u00a9 2013 AASLD.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/lt.23688","type":"journal-article","created":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T11:06:35Z","timestamp":1371553595000},"page":"991-1000","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":35,"title":["Quality of life is significantly impaired in long-term survivors of acute liver failure and particularly in acetaminophen-overdose patients"],"prefix":"10.1097","volume":"19","author":[{"given":"Amol S.","family":"Rangnekar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlyn","family":"Ellerbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Durkalski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan","family":"McGuire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William M.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Fontana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R3-9-20250124","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1053\/jlts.2002.35550","article-title":"Delayed neuropsychologic dysfunction after liver transplantation for acute liver failure: a matched, casecontrolled study.","volume":"8","author":"Jackson","year":"2002","journal-title":"Liver Transpl"},{"key":"R4-9-20250124","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1053\/jlts.2003.50239","article-title":"Cognitive dysfunction and healthrelated quality of life in longterm liver transplant survivors.","volume":"9","author":"Lewis","year":"2003","journal-title":"Liver Transpl"},{"key":"R5-9-20250124","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1002\/lt.21931","article-title":"Longterm outcomes of emergency liver transplantation for acute liver failure.","volume":"15","author":"Chan","year":"2009","journal-title":"Liver Transpl"},{"key":"R6-9-20250124","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1477-7525-4-66","article-title":"Psychometric properties of the Centers for Disease Control and Prevention HealthRelated Quality of Life (CDC HRQOL) items in adults with arthritis.","volume":"4","author":"Mielenz","year":"2006","journal-title":"Health Qual Life Outcomes"},{"key":"R7-9-20250124","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1136\/jech.57.5.339","article-title":"Retest reliability of surveillance questions on health related quality of life.","volume":"57","author":"Andresen","year":"2003","journal-title":"J Epidemiol Community Health"},{"key":"R9-9-20250124","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1111\/j.1399-0012.2012.01597.x","article-title":"Influence of liverdisease etiology on longterm quality of life and employment after liver transplantation.","volume":"26","author":"Aberg","year":"2012","journal-title":"Clin Transplant"},{"key":"R10-9-20250124","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1362-1017.2006.00169.x","article-title":"Quality of life following emergency liver transplantation for acute liver failure.","volume":"11","author":"Sargent","year":"2006","journal-title":"Nurs Crit Care"},{"key":"R11-9-20250124","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.transproceed.2010.11.015","article-title":"Posttraumatic stress disorders, mood disorders, and quality of life in transplant recipients with acute liver failure.","volume":"43","author":"Guimaro","year":"2011","journal-title":"Transplant Proc"},{"key":"R13-9-20250124","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1478-3231.2010.02435.x","article-title":"Enhanced efficacy of pegylated interferon alpha2a over pegylated interferon and ribavirin in chronic hepatitis C genotype 4A randomized trial and quality of life analysis.","volume":"31","author":"Kamal","year":"2011","journal-title":"Liver Int"},{"key":"R14-9-20250124","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1111\/j.1365-2036.2010.04235.x","article-title":"Changes in quality of life and sexual health are associated with lowdose peginterferon therapy and disease progression in patients with chronic hepatitis C.","volume":"31","author":"Snow","year":"2010","journal-title":"Aliment Pharmacol Ther"},{"key":"R16-9-20250124","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1053\/jlts.2000.18499","article-title":"Impact of liver transplantation on healthrelated quality of life.","volume":"6","author":"Younossi","year":"2000","journal-title":"Liver Transpl"},{"key":"R17-9-20250124","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.jhep.2007.12.013","article-title":"Quality of life after liver transplantation. A systematic review.","volume":"48","author":"Tome","year":"2008","journal-title":"J Hepatol"},{"key":"R18-9-20250124","first-page":"281","article-title":"Quality of life and psychosocial situation before and after a lung, liver or an allogeneic bone marrow transplant.","volume":"136","author":"Goetzmann","year":"2006","journal-title":"Swiss Med Wkly"},{"key":"R19-9-20250124","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.amjsurg.2003.07.024","article-title":"Survival and quality of life after organ transplantation in veterans and nonveterans.","volume":"186","author":"Moore","year":"2003","journal-title":"Am J Surg"},{"issue":"suppl 2","key":"R20-9-20250124","first-page":"S42S49","article-title":"Healthrelated quality of life after liver transplantation for adult recipients.","volume":"15","author":"Bownik","year":"2009","journal-title":"Liver Transpl"},{"key":"R21-9-20250124","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1002\/lt.21561","article-title":"Quality of life up to 30 years following liver transplantation.","volume":"14","author":"Desai","year":"2008","journal-title":"Liver Transpl"},{"key":"R22-9-20250124","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/lt.22268","article-title":"Differences in healthrelated quality of life scores after orthotopic liver transplantation with respect to selected socioeconomic factors.","volume":"17","author":"Saab","year":"2011","journal-title":"Liver Transpl"},{"key":"R23-9-20250124","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1097\/SLA.0b013e3181f5f23a","article-title":"Longterm patient outcome and quality of life after liver transplantation: analysis of 20year survivors.","volume":"252","author":"Duffy","year":"2010","journal-title":"Ann Surg"},{"key":"R24-9-20250124","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/j.1399-0012.2007.00672.x","article-title":"Factors influencing change in healthrelated quality of life after liver transplantation.","volume":"21","author":"Estraviz","year":"2007","journal-title":"Clin Transplant"},{"key":"R25-9-20250124","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1007\/s00134-009-1588-z","article-title":"Sixmonth outcome in acute kidney injury requiring renal replacement therapy in the ICU: a multicentre prospective study.","volume":"35","author":"Delannoy","year":"2009","journal-title":"Intensive Care Med"},{"key":"R26-9-20250124","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1227\/NEU.0b013e31820cd40d","article-title":"Healthrelated quality of life after aneurysmal subarachnoid hemorrhage: profile and clinical factors.","volume":"68","author":"Wong","year":"2011","journal-title":"Neurosurgery"},{"key":"R27-9-20250124","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1007\/s00134-009-1616-z","article-title":"Quality of life and functional outcome at 3, 6 and 12 months after acute necrotising pancreatitis.","volume":"35","author":"Wright","year":"2009","journal-title":"Intensive Care Med"},{"key":"R28-9-20250124","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1440-1843.2008.01419.x","article-title":"Cognitive, mood and quality of life impairments in a select population of ARDS survivors.","volume":"14","author":"Mikkelsen","year":"2009","journal-title":"Respirology"},{"key":"R29-9-20250124","doi-asserted-by":"crossref","first-page":"R67","DOI":"10.1186\/cc8967","article-title":"Preexisting disease: the most important factor for health related quality of life longterm after critical illness: a prospective, longitudinal, multicentre trial.","volume":"14","author":"Orwelius","year":"2010","journal-title":"Crit Care"},{"key":"R30-9-20250124","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/art.11381","article-title":"Performance of a generic healthrelated quality of life measure in a clinic population with rheumatic disease.","volume":"49","author":"Currey","year":"2003","journal-title":"Arthritis Rheum"},{"key":"R32-9-20250124","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1089\/jwh.2007.0468","article-title":"Gender differences in coronary heart disease and healthrelated quality of life: findings from 10 states from the 2004 Behavioral Risk Factor Surveillance System.","volume":"17","author":"Ford","year":"2008","journal-title":"J Womens Health (Larchmt)"},{"key":"R33-9-20250124","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1477-7525-2-5","article-title":"Healthrelated quality of life among older adults with arthritis.","volume":"2","author":"Dominick","year":"2004","journal-title":"Health Qual Life Outcomes"},{"key":"R35-9-20250124","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1002\/lt.21799","article-title":"Outcomes of liver transplantation for paracetamol (acetaminophen)induced hepatic failure.","volume":"15","author":"Cooper","year":"2009","journal-title":"Liver Transpl"},{"issue":"suppl 1","key":"R37-9-20250124","first-page":"192A","article-title":"Outcomes and complications of intracranial pressure monitoring in acute liver failure: a retrospective cohort study abstract.","volume":"56","author":"Karvellas","year":"2012","journal-title":"Hepatology"}],"container-title":["Liver Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flt.23688","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flt.23688","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01445473-201309000-00009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T17:23:36Z","timestamp":1737739416000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01445473-201309000-00009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1002\/lt.23688","relation":{},"ISSN":["1527-6465"],"issn-type":[{"value":"1527-6465","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]}}}