{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:09:50Z","timestamp":1777496990066,"version":"3.51.4"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2013,10,10]],"date-time":"2013-10-10T00:00:00Z","timestamp":1381363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>The impact of ischemia\/reperfusion injury in the setting of transplantation for hepatocellular carcinoma (HCC) has not been thoroughly investigated. The present study examined data from the Scientific Registry of Transplant Recipients for all recipients of deceased donor liver transplants performed between January 1, 1995 and October 31, 2011. In a multivariate Cox analysis, significant predictors of patient survival included the following: HCC diagnosis (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.01), donation after cardiac death (DCD) allograft (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001), hepatitis C virus-positive status (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.01), recipient age (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.01), donor age (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001), Model for End-Stage Liver Disease score (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001), recipient race, and an alpha-fetoprotein level &gt; 400 ng\/mL at the time of transplantation. In order to test whether the decreased survival seen for HCC recipients of DCD grafts was more than would be expected because of the inferior nature of DCD grafts and the diagnosis of HCC, a DCD allograft\/HCC diagnosis interaction term was created to look for potentiation of effect. In a multivariate analysis adjusted for all other covariates, this interaction term was statistically significant (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.049) and confirmed that there was potentiation of inferior survival with the use of DCD allografts in recipients with HCC. In conclusion, patient survival and graft survival were inferior for HCC recipients of DCD allografts versus recipients of donation after brain death allografts. This potentiation of effect of inferior survival remained even after adjustments for the inherent inferiority observed in DCD allografts as well as other known risk factors. It is hypothesized that this difference could reflect an increased rate of recurrence of HCC. <jats:italic toggle=\"yes\">Liver Transpl 19:1214\u20131223, 2013<\/jats:italic>. \u00a9 2013 AASLD.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/lt.23715","type":"journal-article","created":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T18:52:44Z","timestamp":1375383164000},"page":"1214-1223","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":62,"title":["Inferior survival in liver transplant recipients with hepatocellular carcinoma receiving donation after cardiac death liver allografts"],"prefix":"10.1097","volume":"19","author":[{"given":"Kris P.","family":"Croome","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Wall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasha","family":"Chandok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gavin","family":"Beck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Marotta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Hernandez-Alejandro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-6-20250124","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1002\/lt.21778","article-title":"An intention-to-treat analysis of liver transplantation for hepatocellular carcinoma using Organ Procurement Transplant Network data.","volume":"15","author":"Pelletier","year":"2009","journal-title":"Liver Transpl"},{"issue":"suppl 2","key":"R2-6-20250124","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1002\/lt.22423","article-title":"Toward optimizing the indications for orthotopic liver transplantation in hepatocellular carcinoma.","volume":"17","author":"Samuel","year":"2011","journal-title":"Liver Transpl"},{"key":"R3-6-20250124","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.jhep.2011.01.040","article-title":"A comprehensive risk assessment of mortality following donation after cardiac death liver transplantan analysis of the national registry.","volume":"55","author":"Jay","year":"2011","journal-title":"J Hepatol"},{"key":"R4-6-20250124","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1002\/lt.21811","article-title":"Liver transplantation using controlled donation after cardiac death donors: an analysis of a large single-center experience.","volume":"15","author":"Grewal","year":"2009","journal-title":"Liver Transpl"},{"key":"R5-6-20250124","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.transproceed.2012.01.115","article-title":"Should a lower quality organ go to the least sick patient? Model for End-Stage Liver Disease score and donor risk index as predictors of early allograft dysfunction.","volume":"44","author":"Croome","year":"2012","journal-title":"Transplant Proc"},{"key":"R6-6-20250124","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1600-6143.2007.02086.x","article-title":"The survival benefit of deceased donor liver transplantation as a function of candidate disease severity and donor quality.","volume":"8","author":"Schaubel","year":"2008","journal-title":"Am J Transplant"},{"key":"R7-6-20250124","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/00024382-199601000-00008","article-title":"Liver ischemia and reperfusion induces a systemic inflammatory response through Kupffer cell activation.","volume":"5","author":"Wanner","year":"1996","journal-title":"Shock"},{"key":"R8-6-20250124","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1097\/SLA.0b013e3182104784","article-title":"Biliary complications after liver 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