{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T20:26:02Z","timestamp":1759177562981,"version":"3.33.0"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2013,10,10]],"date-time":"2013-10-10T00:00:00Z","timestamp":1381363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Liver donor characteristics have a significant impact on graft quality and, in turn, recipient outcomes. In this study, we examined deceased liver donor characteristics and donor risk index (DRI) trends in Canada over the past decade. Data were extracted from the Canadian Organ Replacement Register and Transplant Qu\u00e9bec for the decade (2000-2010). Trends in the DRI and donor characteristics, including age, race, height, cause of death (COD), location, cold ischemia time (CIT), and type of donation, were examined. In all, 3746 transplants using deceased liver donors were analyzed. The age of donors, the proportion of black donors, the proportion of cerebrovascular accidents as the COD, and the proportion of donation after cardiac death (DCD) donors all increased over the aforementioned time period. The proportion of transplants classified geographically as local increased, and the CIT for donor livers decreased. Although many of the parameters adversely affecting the DRI increased over the study period, the DRI showed only a slightly significant trend of increasing. The increase in these parameters was counteracted by a decrease in modifiable risk factors such as the CIT and distance traveled. The 5-year recipient survival rate increased from 71.43% (1999-2001) to 75.50% (2005-2007); however, this trend was not significant. Although there was an increase in the use of older and DCD organs, recipient survival was not compromised. In conclusion, demographic trends for liver donors in Canada suggest an increase in the use of higher risk donors. However, the overall graft quality has been not compromised because of a decreasing trend for the CIT and an increase in local transplants. Better coordination and allocation practices in liver transplantation across Canada have minimized the risk of graft failure and resulted in good recipient outcomes. <jats:italic toggle=\"yes\">Liver Transpl 19:1236\u20131244, 2013<\/jats:italic>. \u00a9 2013 AASLD.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/lt.23718","type":"journal-article","created":{"date-parts":[[2013,8,2]],"date-time":"2013-08-02T13:24:38Z","timestamp":1375449878000},"page":"1236-1244","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":13,"title":["Changing donor characteristics in liver transplantation over the last 10 years in canada"],"prefix":"10.1097","volume":"19","author":[{"given":"Nathalie","family":"Sela","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kris P.","family":"Croome","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasha","family":"Chandok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Marotta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Wall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Hernandez-Alejandro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R2-8-20250124","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s00534-007-1300-z","article-title":"The use of marginal grafts in liver transplantation.","volume":"15","author":"Hashimoto","year":"2008","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"R3-8-20250124","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.transproceed.2012.01.115","article-title":"Should a lower quality organ go to the least sick patient? Model for End-Stage Liver Disease score and donor risk index as predictors of early allograft dysfunction.","volume":"44","author":"Croome","year":"2012","journal-title":"Transplant Proc"},{"key":"R4-8-20250124","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/j.1600-6143.2006.01242.x","article-title":"Characteristics associated with liver graft failure: the concept of a donor risk index.","volume":"6","author":"Feng","year":"2006","journal-title":"Am J Transplant"},{"issue":"pt 2","key":"R5-8-20250124","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/j.1600-6143.2009.03008.x","article-title":"Organ donation and utilization in the United States, 1999-2008.","volume":"10","author":"Klein","year":"2010","journal-title":"Am J Transplant"},{"key":"R6-8-20250124","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1016\/j.transproceed.2008.05.070","article-title":"Donor index and organ patient index as predictors of graft survival after liver transplantation.","volume":"40","author":"Avolio","year":"2008","journal-title":"Transplant Proc"},{"issue":"pt 2","key":"R8-8-20250124","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1111\/j.1600-6143.2010.03037.x","article-title":"Liver transplantation in the United States, 1999-2008.","volume":"10","author":"Thuluvath","year":"2010","journal-title":"Am J Transplant"},{"issue":"pt 2","key":"R9-8-20250124","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1111\/j.1600-6143.2009.02567.x","article-title":"Liver and intestine transplantation in the United States 1998-2007.","volume":"9","author":"Berg","year":"2009","journal-title":"Am J Transplant"},{"key":"R13-8-20250124","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1007\/BF03022802","article-title":"Organ utilization among deceased donors in Canada, 1993-2002.","volume":"53","author":"Badovinac","year":"2006","journal-title":"Can J Anaesth"},{"key":"R16-8-20250124","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1111\/j.1600-6143.2011.03487.x","article-title":"Variation in organ quality between liver transplant centers.","volume":"11","author":"Volk","year":"2011","journal-title":"Am J Transplant"},{"key":"R17-8-20250124","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.jhep.2011.01.040","article-title":"A comprehensive risk assessment of mortality following donation after cardiac death liver transplant an analysis of the national registry.","volume":"55","author":"Jay","year":"2011","journal-title":"J Hepatol"},{"key":"R19-8-20250124","doi-asserted-by":"crossref","first-page":"e2468","DOI":"10.1371\/journal.pone.0002468","article-title":"Consequences of cold-ischemia time on primary nonfunction and patient and graft survival in liver transplantation: a meta-analysis.","volume":"3","author":"Stahl","year":"2008","journal-title":"PLoS One"},{"key":"R20-8-20250124","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1477-2574.2011.00307.x","article-title":"Minimising cold ischaemic time is essential in cardiac death donor-associated liver transplantation.","volume":"13","author":"Karp","year":"2011","journal-title":"HPB (Oxford)"},{"key":"R21-8-20250124","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1111\/j.1600-6143.2008.02314.x","article-title":"Deceased organ donation in Canada: an opportunity to heal a fractured system.","volume":"8","author":"Gill","year":"2008","journal-title":"Am J Transplant"}],"container-title":["Liver Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flt.23718","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flt.23718","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01445473-201311000-00008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T17:27:23Z","timestamp":1737739643000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01445473-201311000-00008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":13,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1002\/lt.23718","relation":{},"ISSN":["1527-6465"],"issn-type":[{"type":"print","value":"1527-6465"}],"subject":[],"published":{"date-parts":[[2013,11]]}}}