{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T13:30:38Z","timestamp":1772199038489,"version":"3.50.1"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T00:00:00Z","timestamp":1404345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The McCusker Foundation","award":["MC-2011-12-001"],"award-info":[{"award-number":["MC-2011-12-001"]}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>This study investigated iron-induced injury after warm ischemia in a non\u2013heart-beating (NHB) rat liver model and the effects of deferoxamine (DFO). Livers from heart-beating (HB) rats or rats that were NHB for 60 minutes were stored in University of Wisconsin solution for 5 hours at 4\u00b0C [cold storage (CS)] and then were subjected to 2 hours of machine reperfusion (MRP) at 37\u00b0C. Three NHB groups were compared: (1) no DFO, (2) DFO 30 minutes before cardiac arrest and during CS and MRP, and (3) DFO during CS and MRP. Aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) levels in the NHB perfusate were significantly elevated (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.01) in comparison with levels in HB controls after CS and MRP. After CS, the levels of iron and tumor necrosis factor \u03b1 (TNF-\u03b1) were 0.077 \u00b1 0.007 \u03bcmol\/g and 151 \u00b1 26 pg\/g, respectively, in the NHB group and 0.022 \u00b1 0.004 \u03bcmol\/g and 17 \u00b1 7 pg\/g, respectively, in the HB group (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.01). After MRP, LDH significantly correlated with iron (<jats:italic toggle=\"yes\">R<\/jats:italic>\n                                 <jats:sup>2<\/jats:sup> = 0.81, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.01). The DFO pretreatment of NHB donors decreased AST (7.3 \u00b1 0.8 versus 4.0 \u00b1 0.5 U\/g of liver, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.05) and LDH (42.5 \u00b1 4.1 versus 20.4 \u00b1 2.5 U\/g of liver, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.05) with 2 hours of MRP and increased bile flow during MRP (142 \u00b1 34 versus 240 \u00b1 18 \u03bcL\/g, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.05). It also reduced the levels of iron (0.077 \u00b1 0.007 versus 0.050 \u00b1 0.008 \u03bcmol\/g, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.05) and TNF-\u03b1 (151 \u00b1 26 versus 51 \u00b1 13 pg\/g, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.05) after CS and the levels of lipid peroxidation products F2-isoprostane (149 \u00b1 11 versus 99 \u00b1 10 ng\/g, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.05) and malondialdehyde (1.58 \u00b1 0.1 versus 1.14 \u00b1 0.08 \u03bcmol\/g, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.05) after MRP. In conclusion, iron-initiated oxidative stress is likely involved in NHB donor liver injury, and importantly, DFO pretreatment reduces liver damage. <jats:italic toggle=\"yes\">Liver Transpl 20:904\u2013911, 2014<\/jats:italic>. \u00a9 2014 AASLD.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/lt.23893","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T02:46:41Z","timestamp":1397962001000},"page":"904-911","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["Iron-induced oxidative rat liver injury after non\u2013heart-beating warm ischemia is mediated by tumor necrosis factor \u03b1 and prevented by deferoxamine"],"prefix":"10.1097","volume":"20","author":[{"given":"Xianwa","family":"Niu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen Hua","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bastiaan","family":"De Boer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc","family":"Delriviere","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling Jun","family":"Mou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary P.","family":"Jeffrey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-7-20250124","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1111\/j.1600-6143.2011.03587.x","article-title":"Major challenges limiting liver transplantation in the United States.","volume":"11","author":"Wertheim","year":"2011","journal-title":"Am J 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