{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:22:04Z","timestamp":1792214524564,"version":"4.4.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":330,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"NIH","award":["U01-DK62444"],"award-info":[{"award-number":["U01-DK62444"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>Adult\u2010to\u2010adult living donors and recipients were studied to characterize patterns of liver growth and identify associated factors in a multicenter study. Three hundred and fifty donors and 353 recipients in the Adult\u2010to\u2010Adult Living Donor Liver Transplantation Cohort Study (A2ALL) receiving transplants between March 2003 and February 2010 were included. Potential predictors of 3\u2010month liver volume included total and standard liver volumes (TLV and SLV), Model for End\u2010Stage Liver Disease (MELD) score (in recipients), the remnant and graft size, remnant\u2010to\u2010donor and graft\u2010to\u2010recipient weight ratios (RDWR and GRWR), remnant\/TLV, and graft\/SLV. Among donors, 3\u2010month absolute growth was 676\u2009\u00b1\u2009251 g (mean\u2009\u00b1\u2009SD), and percentage reconstitution was 80%\u2009\u00b1\u200913%. Among recipients, GRWR was 1.3%\u2009\u00b1\u20090.4% (8\u2009&lt;\u20090.8%). Graft weight was 60%\u2009\u00b1\u200913% of SLV. Three\u2010month absolute growth was 549\u2009\u00b1\u2009267 g, and percentage reconstitution was 93%\u2009\u00b1\u200918%. Predictors of greater 3\u2010month liver volume included larger patient size (donors and recipients), larger graft volume (recipients), and larger TLV (donors). Donors with the smallest remnant\/TLV ratios had larger than expected growth but also had higher postoperative bilirubin and international normalized ratio at 7 and 30 days. In a combined donor\u2010recipient analysis, donors had smaller 3\u2010month liver volumes than recipients adjusted for patient size, remnant or graft volume, and TLV or SLV (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.004). Recipient graft failure in the first 90 days was predicted by poor graft function at day 7 (HR\u2009=\u20094.50, <jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.001) but not by GRWR or graft fraction (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009&gt;\u20090.90 for each). Both donors and recipients had rapid yet incomplete restoration of tissue mass in the first 3 months, and this confirmed previous reports. Recipients achieved a greater percentage of expected total volume. Patient size and recipient graft volume significantly influenced 3\u2010month volumes. Importantly, donor liver volume is a critical predictor of the rate of regeneration, and donor remnant fraction affects postresection function. <jats:italic toggle=\"yes\">Liver Transpl 21:79\u201088, 2015<\/jats:italic>. \u00a9 2014 AASLD.<\/jats:p>","DOI":"10.1002\/lt.23966","type":"journal-article","created":{"date-parts":[[2014,7,28]],"date-time":"2014-07-28T09:56:01Z","timestamp":1406541361000},"page":"79-88","source":"Crossref","is-referenced-by-count":97,"title":["Liver regeneration after living donor transplantation: Adult\u2010to\u2010adult living donor liver transplantation cohort study"],"prefix":"10.1097","volume":"21","author":[{"given":"Kim M.","family":"Olthoff","sequence":"first","affiliation":[{"name":"Department of Surgery,University of Pennsylvania School of Medicine,Philadelphia,PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean C.","family":"Emond","sequence":"additional","affiliation":[{"name":"Columbia University,New York,NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tempie H.","family":"Shearon","sequence":"additional","affiliation":[{"name":"University of Michigan,Ann Arbor,MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Everson","sequence":"additional","affiliation":[{"name":"University of Colorado Denver,Aurora,CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talia B.","family":"Baker","sequence":"additional","affiliation":[{"name":"Northwestern University,Chicago,IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Virginia Commonwealth University,Richmond,VA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris E.","family":"Freise","sequence":"additional","affiliation":[{"name":"University of California San Francisco,San Francisco,CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda W.","family":"Gillespie","sequence":"additional","affiliation":[{"name":"University of Michigan,Ann Arbor,MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Everhart","sequence":"additional","affiliation":[{"name":"Division of Digestive Diseases and Nutrition,National Institutes of Diabetes and Digestive and Kidney Diseases,Bethesda,MD"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2014,10,6]]},"reference":[{"issue":"suppl 1","key":"lt23966-bib-0001-20240115","first-page":"S45","article-title":"Liver regeneration","volume":"43","year":"2006","journal-title":"Hepatology"},{"key":"lt23966-bib-0002-20240115","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1002\/lt.22288","article-title":"Outcomes of adult living donor liver transplantation: comparison of the Adult\u2010to\u2010Adult Living Donor Living Donor Liver Transplantation Cohort Study and the national 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Transpl"},{"key":"lt23966-bib-0006-20240115","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1097\/00007890-200004150-00028","article-title":"Liver regeneration and function in donor and recipient after right lobe adult to adult living donor liver transplantation","volume":"69","year":"2000","journal-title":"Transplantation"},{"key":"lt23966-bib-0007-20240115","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1002\/lt.22043","article-title":"Left lobe adult\u2010to\u2010adult living donor liver transplantation: small grafts and hemiportocaval shunts in the prevention of small\u2010for\u2010size syndrome","volume":"16","year":"2010","journal-title":"Liver Transpl"},{"key":"lt23966-bib-0008-20240115","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.transproceed.2010.03.007","article-title":"Regeneration rate of left liver grafts in adult living donor liver transplant","volume":"42","year":"2010","journal-title":"Transplant 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after living donor liver transplantation: long\u2010term follow\u2010up using CT and MR imaging","volume":"186","year":"2014","journal-title":"Rofo"},{"key":"lt23966-bib-0022-20240115","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1007\/s00268-012-1496-1","article-title":"Donor age affects liver regeneration during early period in the graft liver and late period in the remnant liver after living donor liver transplantation","volume":"36","year":"2012","journal-title":"World J Surg"},{"key":"lt23966-bib-0023-20240115","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/lt.20592","article-title":"Outcome of donors with a remnant liver volume of less than 35% after right hepatectomy","volume":"12","year":"2006","journal-title":"Liver Transpl"},{"key":"lt23966-bib-0024-20240115","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1002\/lt.20182","article-title":"Volumetric and functional recovery of the liver after right hepatectomy for living 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