{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:29:22Z","timestamp":1791311362863,"version":"4.3.1"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":221,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>Hepatic artery stenosis (HAS) is thought to predispose patients to biliary complications secondary to ischemic injury. Despite this, the clinical significance of HAS remains poorly defined. The aims of this study were to determine the prevalence and outcomes of HAS and to define which patients might benefit from endovascular treatment. From a prospective database of 662 adult patients undergoing liver transplantation between 2000 and 2011, we identified 54 patients who developed HAS. HAS was defined as any stenosis\u2009&gt;\u200970% that was seen during multidetector computed tomographic angiography (MDCTA) or digital subtraction angiography. The benefit of endovascular therapy was evaluated with propensity score matching. New biliary complications occurred in 17 patients (31.4%), and 23 of the 54 study patients with HAS received endovascular treatment. Among the propensity score\u2013matched patients, the biliary stricture\u2013free survival time was significantly longer for those who received endovascular therapy (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.03). An incidental diagnosis (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.07) and a time from transplantation\u2009&gt;\u20096 months (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.021) were associated with a reduced risk of developing biliary stricture. Patients with symptomatic HAS who received treatment had better biliary stricture\u2013free survival than patients who were treated conservatively, although no significant difference was recorded (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.11). No patient with asymptomatic HAS and normal liver function tests developed biliary strictures. In conclusion, HAS intervention was associated with improved biliary stricture\u2013free survival. In patients with late\u2010onset HAS (\u22656 months) and asymptomatic patients, endovascular treatment is not warranted. <jats:italic toggle=\"yes\">Liver Transpl 21:162\u2010168, 2015<\/jats:italic>. \u00a9 2014 AASLD.<\/jats:p>","DOI":"10.1002\/lt.24043","type":"journal-article","created":{"date-parts":[[2014,11,6]],"date-time":"2014-11-06T23:36:11Z","timestamp":1415316971000},"page":"162-168","source":"Crossref","is-referenced-by-count":46,"title":["Hepatic artery stenosis after liver transplantation: Is endovascular treatment always necessary?"],"prefix":"10.1097","volume":"21","author":[{"given":"Carlo","family":"Pulitano","sequence":"first","affiliation":[{"name":"Australian National Liver Transplant Unit,Royal Prince Alfred Hospital,Sydney,Australia"},{"name":"Centenary Research Institute, University of Sydney,Sydney,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Joseph","sequence":"additional","affiliation":[{"name":"Australian National Liver Transplant Unit,Royal Prince Alfred Hospital,Sydney,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charbel","family":"Sandroussi","sequence":"additional","affiliation":[{"name":"Australian National Liver Transplant Unit,Royal Prince Alfred Hospital,Sydney,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Verran","sequence":"additional","affiliation":[{"name":"Australian National Liver Transplant Unit,Royal Prince Alfred Hospital,Sydney,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone I.","family":"Strasser","sequence":"additional","affiliation":[{"name":"Australian National Liver Transplant Unit,Royal Prince Alfred Hospital,Sydney,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas A.","family":"Shackel","sequence":"additional","affiliation":[{"name":"Australian National Liver Transplant Unit,Royal Prince Alfred Hospital,Sydney,Australia"},{"name":"Centenary Research Institute, University of Sydney,Sydney,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey W.","family":"McCaughan","sequence":"additional","affiliation":[{"name":"Australian National Liver Transplant Unit,Royal Prince Alfred Hospital,Sydney,Australia"},{"name":"Centenary Research Institute, University of Sydney,Sydney,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Crawford","sequence":"additional","affiliation":[{"name":"Australian National Liver Transplant Unit,Royal Prince Alfred Hospital,Sydney,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2015,1,23]]},"reference":[{"key":"lt24043-bib-0001-20240115","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.jamcollsurg.2008.12.032","article-title":"Vascular complications of orthotopic liver transplantation: experience in 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