{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T16:09:49Z","timestamp":1785168589425,"version":"3.55.0"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2015,2,10]],"date-time":"2015-02-10T00:00:00Z","timestamp":1423526400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2015,2,10]],"date-time":"2015-02-10T00:00:00Z","timestamp":1423526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:p>Hepatorenal syndrome type 1 (HRS1) is acute renal failure in the setting of advanced cirrhosis, and it results from hemodynamic derangements, which should be fully reversible after liver transplantation. However, the rate of hepatorenal syndrome (HRS) reversal and factors predicting renal outcomes after transplantation have not been fully elucidated. The aim of this study was to assess outcomes of HRS1 patients after liver transplantation and factors predicting HRS reversal. A chart review of all liver transplant patients with HRS1 (according to International Ascites Club criteria) at Toronto General Hospital from 2001 to 2010 was conducted. Patient demographic data, pretransplant and posttransplant laboratory data, and the presence of and time to posttransplant HRS reversal (serum creatinine\u2009&lt;\u20091.5 mg\/dL) were extracted from the center's transplant electronic database. Patients were followed until death or the end of the 2011 calendar year. Sixty\u2010two patients (mean age, 54.7\u2009\u00b1\u20091.2 years; mean Model for End\u2010Stage Liver Disease score, 35\u2009\u00b1\u20091) with HRS1 (serum creatinine, 3.37\u2009\u00b1\u20090.13 mg\/dL) at liver transplant were enrolled. Thirty\u2010eight patients received midodrine, octreotide, and albumin without success and subsequently received renal dialysis. One further patient received dialysis without pharmacotherapy. After liver transplantation, HRS1 resolved in 47 of 62 patients (75.8%) at a mean time of 13\u2009\u00b1\u20092 days. Patients without HRS reversal had significantly higher pretransplant serum creatinine levels (3.81\u2009\u00b1\u20090.34 versus 3.23\u2009\u00b1\u20090.14 mg\/dL,<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.06), a longer duration of HRS1 {25 days [95% confidence interval (CI), 16\u201042 days] versus 10 days (95% CI, 10\u201018 days),<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.02}, a longer duration of pretransplant dialysis [27 days (95% CI, 13\u201041 days) versus 10 days (95% CI, 6\u201014 days),<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.01], and increased posttransplant mortality (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.0045) in comparison with those whose renal function recovered. The only predictor of HRS1 nonreversal was the duration of pretransplant dialysis with a 6% increased risk of nonreversal with each additional day of dialysis. In conclusion, our study suggests that patients with HRS1 should receive a timely liver transplant to improve their outcome.<jats:italic toggle=\"yes\">Liver Transpl 21:300\u2013307, 2015<\/jats:italic>. \u00a9 2015 AASLD.<\/jats:p>","DOI":"10.1002\/lt.24049","type":"journal-article","created":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T09:25:55Z","timestamp":1416907555000},"page":"300-307","source":"Crossref","is-referenced-by-count":137,"title":["Outcomes of patients with cirrhosis and hepatorenal syndrome type 1 treated with liver transplantation"],"prefix":"10.1097","volume":"21","author":[{"given":"Florence","family":"Wong","sequence":"first","affiliation":[{"name":"Division of Gastroenterology,Department of Medicine,Toronto General Hospital, University of Toronto,Toronto,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wesley","family":"Leung","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology,Department of Medicine,Toronto General Hospital, University of Toronto,Toronto,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Al Beshir","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology,Department of Medicine,Toronto General Hospital, University of Toronto,Toronto,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Marquez","sequence":"additional","affiliation":[{"name":"Liver Transplant Program\/Multiorgan Transplant Program,University Health Network\/Toronto General Hospital,Toronto,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eberhard L.","family":"Renner","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology,Department of Medicine,Toronto General Hospital, University of Toronto,Toronto,Canada"},{"name":"Liver Transplant Program\/Multiorgan Transplant Program,University Health Network\/Toronto General Hospital,Toronto,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2015,2,10]]},"reference":[{"key":"lt24049-bib-0001-20240115","first-page":"1310","article-title":"Diagnosis, prevention and treatment of hepatorenal syndrome in cirrhosis","volume":"56","year":"2007","journal-title":"Gut"},{"key":"lt24049-bib-0002-20240115","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1002\/hep.20687","article-title":"MELD score and clinical type predict prognosis in hepatorenal syndrome: relevance to liver transplantation","volume":"41","year":"2005","journal-title":"Hepatology"},{"key":"lt24049-bib-0003-20240115","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1053\/j.gastro.2008.02.024","article-title":"Terlipressin and albumin vs albumin in patients with cirrhosis and hepatorenal syndrome: a randomized 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