{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:51:45Z","timestamp":1761630705577,"version":"3.40.5"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":221,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5U01DK62483"],"award-info":[{"award-number":["5U01DK62483"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>Previous reports have drawn attention to persistently decreased platelet counts among liver donors. We hypothesized an etiologic association between altered platelet counts and postdonation splenomegaly and sought to explore this relationship. This study analyzed de\u2010identified computed tomography\/magnetic resonance scans of 388 donors from 9 Adult\u2010to\u2010Adult Living Donor Liver Transplantation Cohort Study centers read at a central computational image analysis laboratory. Resulting liver and spleen volumes were correlated with time\u2010matched clinical laboratory values. Predonation liver volumes varied 2\u2010fold in healthy subjects, even when they were normalized by the body surface area (BSA; range\u2009=\u2009522\u20101887 cc\/m<jats:sup>2<\/jats:sup>, n\u2009=\u2009346). At month 3 (M3), postdonation liver volumes were, on average, 79% of predonation volumes [interquartile range (IQR)\u2009=\u200973%\u201086%, n\u2009=\u2009165] and approached 88% at year 1 (Y1; IQR\u2009=\u200980%\u201093%, n\u2009=\u200975). The mean spleen volume before donation was 245 cc (n\u2009=\u2009346). Spleen volumes greater than 100% of the predonation volume occurred in 92% of donors at M3 (n\u2009=\u2009165) and in 88% at Y1 after donation (n\u2009=\u200975). We sought to develop a standard spleen volume (SSV) model to predict normal spleen volumes in donors before donation and found that decreased platelet counts, a younger age, a higher predonation liver volume, higher hemoglobin levels, and a higher BSA predicted a larger spleen volume (n\u2009=\u2009344,<jats:italic toggle=\"yes\">R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.52). When this was applied to postdonation values, some large volumes were underpredicted by the SSV model. Models developed on the basis of the reduced sample of postdonation volumes yielded smaller underpredictions. These findings confirm previous observations of thrombocytopenia being associated with splenomegaly after donation. The results of the SSV model suggest that the biology of this phenomenon is complex. This merits further long\u2010term mechanistic studies of liver donors with an investigation of the role of other factors such as thrombopoietin and exposure to viral infections to better understand the evolution of the spleen volume after liver donation.<jats:italic toggle=\"yes\">Liver Transpl 21:151\u2010161, 2015<\/jats:italic>. \u00a9 2014 AASLD.<\/jats:p>","DOI":"10.1002\/lt.24062","type":"journal-article","created":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T07:09:00Z","timestamp":1418108940000},"page":"151-161","source":"Crossref","is-referenced-by-count":22,"title":["Changes in liver and spleen volumes after living liver donation: A report from the adult\u2010to\u2010adult living donor liver transplantation cohort study (A2ALL)"],"prefix":"10.1097","volume":"21","author":[{"given":"Jean C.","family":"Emond","sequence":"first","affiliation":[{"name":"Center for Liver Disease and Transplantation,Columbia University,New York,NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Surgery,Virginia Commonwealth University,Richmond,VA"},{"name":"Transplant Institute,Harvard Medical School,Boston,MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Everson","sequence":"additional","affiliation":[{"name":"Section of Hepatology,University of Colorado Denver,Aurora,CO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Samstein","sequence":"additional","affiliation":[{"name":"Center for Liver Disease and Transplantation,Columbia University,New York,NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James J.","family":"Pomposelli","sequence":"additional","affiliation":[{"name":"Department of Transplantation,Lahey Hospital and Medical Center,Burlington,MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binsheng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiology,Columbia University Medical Center,New York,NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Forney","sequence":"additional","affiliation":[{"name":"Arbor Research Collaborative for Health,Ann Arbor,MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim M.","family":"Olthoff","sequence":"additional","affiliation":[{"name":"Department of Surgery,University of Pennsylvania,Philadelphia,PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Talia B.","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Surgery,Northwestern University,Chicago,IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenda W.","family":"Gillespie","sequence":"additional","affiliation":[{"name":"Departments of Biostatistics,University of Michigan,Ann Arbor,MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M.","family":"Merion","sequence":"additional","affiliation":[{"name":"Arbor Research Collaborative for Health,Ann Arbor,MI"},{"name":"Department of Surgery,University of Michigan,Ann Arbor,MI"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2015,1,23]]},"reference":[{"key":"lt24062-bib-0001-20240115","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1097\/01.sla.0000179646.37145.ef","article-title":"Outcomes of 385 adult\u2010to\u2010adult living donor liver transplant recipients: a report from the A2ALL consortium","volume":"242","year":"2005","journal-title":"Ann Surg"},{"key":"lt24062-bib-0002-20240115","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1053\/jlts.2002.30981","article-title":"Living donor liver transplantation: summary of a conference at the National Institutes of 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