{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:07:16Z","timestamp":1791184036509,"version":"4.1.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":155,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:p>In France, decisions regarding superurgent (SU) liver transplantation (LT) for patients with acute liver failure (ALF) are principally based on the Clichy\u2010Villejuif (CV) criteria. The aims of the present study were to study the outcomes of patients registered for SU LT and the factors that were predictive of spontaneous improvement and to determine the usefulness of the CV criteria. All patients listed in France for SU LT between 1997 and 2010 who were 15 years old or older with ALF were included. In all, 808 patients were listed for SU transplantation: 22% with paracetamol\u2010induced ALF and 78% with non\u2013paracetamol\u2010induced ALF. Of these 808 patients, 112 improved spontaneously, 587 underwent LT, and 109 died or left the waiting list because of a worsening condition. The 1\u2010year survival rate according to an intention\u2010to\u2010treat analysis and the survival after LT were 66.3% [interquartile range (IQR), 62.7%\u201069.7%] and 74.2% (IQR, 70.5%\u201077.6%), respectively. The factors that were predictive of a spontaneous recovery with ALF\u2010related paracetamol hepatotoxicity were as follows: hepatic encephalopathy grade 0, 1, or 2 [odds ratio (OR), 4.8; 95% confidence interval (CI), 1.99\u201011.6]; creatinine clearance\u2009\u2265\u200960 mL\/minute\/1.73 m<jats:sup>2<\/jats:sup> (OR, 4.77; 95% CI, 1.96\u201011.63), a bilirubin level\u2009&lt;\u2009200 \u00b5mol\/L (OR, 21.64; 95% CI, 1.76\u2010265.7); and a factor V level\u2009&gt;\u200920% (OR, 5.79; 95% CI, 1.66\u201020.29). For ALF\u2010related nonparacetamol hepatotoxicity, the factor that was predictive of a spontaneous recovery was a bilirubin level\u2009&lt;\u2009200 \u00b5mol\/L (OR, 10.38; 95% CI, 4.71\u201022.86). The sensitivity, specificity, and positive and negative predictive values for the CV criteria were 75%, 56%, 50%, and 79%, respectively, for ALF due to paracetamol and 69%, 50%, 64%, and 55%, respectively, for ALF not related to paracetamol. The performance of current criteria for SU transplantation could be improved if paracetamol\u2010induced ALF and non\u2013paracetamol\u2010induced ALF were split and 2 other items were included in this model: the bilirubin level and creatinine clearance. <jats:italic toggle=\"yes\">Liver Transpl 21:512\u2010523, 2015<\/jats:italic>. \u00a9 2015 AASLD.<\/jats:p>","DOI":"10.1002\/lt.24092","type":"journal-article","created":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T04:09:10Z","timestamp":1423800550000},"page":"512-523","source":"Crossref","is-referenced-by-count":63,"title":["Patients with acute liver failure listed for superurgent liver transplantation in France: Reevaluation of the clichy\u2010villejuif criteria"],"prefix":"10.1097","volume":"21","author":[{"given":"Philippe","family":"Ichai","sequence":"first","affiliation":[{"name":"Liver Intensive Care Unit,Centre Hepato\u2010Biliaire, H\u00f4pital Paul Brousse,AP\u2010HP,Villejuif,France"},{"name":"Unite 785, Inserm,Villejuif,France"},{"name":"Unit\u00e9s Mixtes de Recherche en Sant\u00e9 785,Universit\u00e9 Paris\u2010Sud,Villejuif,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Legeai","sequence":"additional","affiliation":[{"name":"Agence de la Biom\u00e9decine, La Plaine Saint\u2010Denis,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Francoz","sequence":"additional","affiliation":[{"name":"H\u00f4pital Beaujon, AP\u2010HP,Clichy,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Boudjema","sequence":"additional","affiliation":[{"name":"H\u00f4pital Pontchaillou,Centre Hospitalier Universitaire de Rennes,Rennes,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Boillot","sequence":"additional","affiliation":[{"name":"H\u00f4pital Edouard Herriot"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Ducerf","sequence":"additional","affiliation":[{"name":"H\u00f4pital de la Croix\u2010Rousse,Hospices Civils de Lyon,Lyon,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Mathurin","sequence":"additional","affiliation":[{"name":"H\u00f4pital Claude Huriez,Centre Hospitalier R\u00e9gional Universitaire de Lille,Lille,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois\u2010Ren\u00e9","family":"Pruvot","sequence":"additional","affiliation":[{"name":"H\u00f4pital Claude Huriez,Centre Hospitalier R\u00e9gional Universitaire de Lille,Lille,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Suc","sequence":"additional","affiliation":[{"name":"H\u00f4pital de Rangueil,Centre Hospitalier Universitaire de Toulouse,Toulouse,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Wolf","sequence":"additional","affiliation":[{"name":"H\u00f4pital de Hautepierre,Centre Hospitalier Universitaire de Strasbourg,Strasbourg,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Soubrane","sequence":"additional","affiliation":[{"name":"H\u00f4pital Saint\u2010Antoine, AP\u2010HP,Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves Patrice Le","family":"Treut","sequence":"additional","affiliation":[{"name":"H\u00f4pital de la Conception, AP\u2010HM,Marseille,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Cherqui","sequence":"additional","affiliation":[{"name":"H\u00f4pital Henri Mondor, AP\u2010HP,Cr\u00e9teil,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Hannoun","sequence":"additional","affiliation":[{"name":"Groupe Hospitalier Piti\u00e9\u2010Salp\u00e9tri\u00e8re, AP\u2010HP,Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges\u2010Philippe","family":"Pageaux","sequence":"additional","affiliation":[{"name":"H\u00f4pital Saint Eloi,Centre Hospitalier Universitaire de Montpellier,Montpellier,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Gugenheim","sequence":"additional","affiliation":[{"name":"H\u00f4pital de l'Archet,Centre Hospitalier Universitaire de Nice,Nice,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Letoublon","sequence":"additional","affiliation":[{"name":"H\u00f4pital Michallon,Centre Hospitalier Universitaire de Grenoble,Grenoble,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Saric","sequence":"additional","affiliation":[{"name":"H\u00f4pital Pellegrin,Centre Hospitalier Universitaire de Bordeaux,Bordeaux,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent Di","family":"Martino","sequence":"additional","affiliation":[{"name":"H\u00f4pital Jean Minjoz,Centre Hospitalier Universitaire de Besan\u00e7on,Besan\u00e7on,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armand","family":"Abergel","sequence":"additional","affiliation":[{"name":"H\u00f4pital de l'Estaing,Centre Hospitalier Universitaire de Clermont\u2010Ferrand,Clermont\u2010Ferrand,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Chiche","sequence":"additional","affiliation":[{"name":"H\u00f4pital de la C\u00f4te de Nacre,Centre Hospitalier Universitaire de Caen,Caen,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa Maria","family":"Antonini","sequence":"additional","affiliation":[{"name":"Liver Intensive Care Unit,Centre Hepato\u2010Biliaire, H\u00f4pital Paul Brousse,AP\u2010HP,Villejuif,France"},{"name":"Unite 785, Inserm,Villejuif,France"},{"name":"Unit\u00e9s Mixtes de Recherche en Sant\u00e9 785,Universit\u00e9 Paris\u2010Sud,Villejuif,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Jacquelinet","sequence":"additional","affiliation":[{"name":"Agence de la Biom\u00e9decine, La Plaine Saint\u2010Denis,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Castaing","sequence":"additional","affiliation":[{"name":"Liver Intensive Care Unit,Centre Hepato\u2010Biliaire, H\u00f4pital Paul Brousse,AP\u2010HP,Villejuif,France"},{"name":"Unite 785, Inserm,Villejuif,France"},{"name":"Unit\u00e9s Mixtes de Recherche en Sant\u00e9 785,Universit\u00e9 Paris\u2010Sud,Villejuif,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Samuel","sequence":"additional","affiliation":[{"name":"Liver Intensive Care Unit,Centre Hepato\u2010Biliaire, H\u00f4pital Paul Brousse,AP\u2010HP,Villejuif,France"},{"name":"Unite 785, Inserm,Villejuif,France"},{"name":"Unit\u00e9s Mixtes de Recherche en Sant\u00e9 785,Universit\u00e9 Paris\u2010Sud,Villejuif,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the French Liver Transplant Teams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2015,3,30]]},"reference":[{"key":"lt24092-bib-0001-20240115","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0140-6736(10)60274-7","article-title":"Acute liver 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