{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:48:57Z","timestamp":1786978137420,"version":"build-2736575974"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":120,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"The Ministry of Health, Labor, and Welfare of Japan","award":["H25-Shinko-Ippan-009"],"award-info":[{"award-number":["H25-Shinko-Ippan-009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:p>\n                    After liver transplantation (LT), live attenuated vaccines (LAVs) are generally contraindicated. LAVs are recommended before LT for patients\u2009\u2265\u20096 months of age. However, the evidence supporting this practice is limited. Patients were enrolled before and after LT. Clinical data for patients were obtained from medical records. Serum antibody titers were evaluated at the time of enrollment and prospectively. Serum antibody titers were measured with a hemagglutination inhibition test for measles and rubella and with an enzyme\u2010linked immunosorbent assay for varicella and mumps. Univariate and multivariate analyses were performed to investigate the factors that affect the serostatus. Serological analyses of 49 patients immunized before LT (median age, 45 months; male, 35%) were performed. Underlying diseases were biliary atresia (n\u2009=\u200927; 55%), metabolic diseases (n\u2009=\u200913; 27%), fulminant hepatic failure (n\u2009=\u20095; 10%), and others (n\u2009=\u20094; 8%). The seropositivity rate after each vaccine was 46.9% (measles), 89.4% (rubella), 67.5% (varicella), and 48.8% (mumps). Factors independently associated with seronegativity were a vaccination age\u2009&lt;\u200912 months for measles (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.002), a lower body weight for varicella (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u20090.01), and underlying diseases other than biliary atresia for mumps (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.004). No serious adverse event was observed during the study period. The immunogenicity of LAVs before LT was high for rubella but low for the others. Before LT, further vaccination strategies are needed for patients. In addition, serological follow\u2010up may be indicated for patients with factors associated with seronegativity.\n                    <jats:italic toggle=\"yes\">Liver Transpl 21:774\u2013783, 2015<\/jats:italic>\n                    . \u00a9 2015 AASLD.\n                  <\/jats:p>","DOI":"10.1002\/lt.24104","type":"journal-article","created":{"date-parts":[[2015,3,11]],"date-time":"2015-03-11T19:37:05Z","timestamp":1426102625000},"page":"774-783","source":"Crossref","is-referenced-by-count":18,"title":["Serostatus following live attenuated vaccination administered before pediatric liver transplantation"],"prefix":"10.1097","volume":"21","author":[{"given":"Takanori","family":"Funaki","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medical Subspecialties,Center for Transplant Surgery, National Center for Child Health and Development,Tokyo,Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Shoji","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medical Subspecialties,Center for Transplant Surgery, National Center for Child Health and Development,Tokyo,Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ippei","family":"Miyata","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medical Subspecialties,Center for Transplant Surgery, National Center for Child Health and Development,Tokyo,Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seisuke","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery,Center for Transplant Surgery, National Center for Child Health and Development,Tokyo,Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mureo","family":"Kasahara","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery,Center for Transplant Surgery, National Center for Child Health and Development,Tokyo,Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironori","family":"Yoshii","sequence":"additional","affiliation":[{"name":"Research Foundation for Microbial Diseases of Osaka University,Kagawa,Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Miyairi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medical Subspecialties,Center for Transplant Surgery, National Center for Child Health and Development,Tokyo,Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Saitoh","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medical Subspecialties,Center for Transplant Surgery, National Center for Child Health and Development,Tokyo,Japan"},{"name":"Department of Pediatrics,Niigata University Graduate School of Medical and Dental Sciences,Niigata University,Niigata,Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2015,5,4]]},"reference":[{"key":"lt24104-bib-0001-20240115","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1001\/jama.1992.03480090085032","article-title":"Severe measles in immunocompromised patients","volume":"267","year":"1992","journal-title":"JAMA"},{"key":"lt24104-bib-0002-20240115","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1034\/j.1399-3046.2001.00048.x","article-title":"Varicella\u2010zoster infection in pediatric solid\u2010organ transplant recipients: a hospital\u2010based study in the prevaricella vaccine era","volume":"5","year":"2001","journal-title":"Pediatr Transplant"},{"issue":"suppl 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