{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T10:02:33Z","timestamp":1790330553980,"version":"4.1.0"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","license":[{"start":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T00:00:00Z","timestamp":1435276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T00:00:00Z","timestamp":1435276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:p>Split liver transplantation (SLT) has proven to be an effective technique to reduce the mortality of children on the waiting list, but whether creating 2 split grafts from 1 standard\u2010criteria whole liver would compromise outcomes of adult recipients remains uncertain. We conducted this meta\u2010analysis to compare outcomes of right lobe SLT and whole liver transplantation (WLT) in adult patients. PubMed, Embase, and the Cochrane Library were searched for relevant articles published before December 2014. Outcomes assessed were patient survival (PS), graft survival (GS), and major surgical complications after transplantation. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to synthesize the results. Seventeen studies with a total of 48,457 patients met the full inclusion criteria. PS and GS rates were all found to be equivalent between SLT and WLT recipients. However, SLT was associated with higher rates of overall biliary complications (OR = 1.66; 95% CI = 1.29\u20102.15; <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001), bile leaks (OR = 4.30; 95% CI = 2.97\u20106.23; <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001), overall vascular complications (OR = 1.81; 95% CI = 1.29\u20102.53; <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001), hepatic artery thromboses (OR = 1.71; 95% CI = 1.17\u20102.50; <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.005), and outflow tract obstructions (OR = 4.17; 95% CI = 1.75\u20109.94; <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.001). No significant difference was observed in incidences of biliary stricture, portal vein complications, postoperative bleeding requiring surgical treatments, primary nonfunction, and retransplantations. In subgroup analyses, biliary and vascular complications only increased after ex vivo SLT rather than in situ SLT, and SLT recipients had more retransplantations if they matched with WLT recipients in terms of urgent status. In conclusion, adult right lobe SLT was associated with increased biliary and vascular complications compared with WLT, but it did not show significant inferiority in PSs and GSs. <jats:italic toggle=\"yes\">Liver Transpl 21:928\u2010943, 2015<\/jats:italic>. \u00a9 2015 AASLD.<\/jats:p>","DOI":"10.1002\/lt.24135","type":"journal-article","created":{"date-parts":[[2015,4,2]],"date-time":"2015-04-02T22:06:48Z","timestamp":1428012408000},"page":"928-943","source":"Crossref","is-referenced-by-count":57,"title":["Right lobe split liver transplantation versus whole liver transplantation in adult recipients: A systematic review and meta\u2010analysis"],"prefix":"10.1097","volume":"21","author":[{"given":"Ping","family":"Wan","sequence":"first","affiliation":[{"name":"Department of Liver Surgery, Ren Ji Hospital, School of Medicine,Shanghai Jiao Tong University,Shanghai,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qigen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery, Ren Ji Hospital, School of Medicine,Shanghai Jiao Tong University,Shanghai,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery, Ren Ji Hospital, School of Medicine,Shanghai Jiao Tong University,Shanghai,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery, Ren Ji Hospital, School of Medicine,Shanghai Jiao Tong University,Shanghai,China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2015,6,26]]},"reference":[{"key":"lt24135-bib-0001-20240115","first-page":"659","article-title":"Homotransplantation of the liver in humans","volume":"117","year":"1963","journal-title":"Surg Gynecol Obstet"},{"key":"lt24135-bib-0002-20240115","first-page":"127","article-title":"Transplantation of a donor liver to 2 recipients (splitting transplantation)\u2010\u2010a new method in the further development of segmental liver transplantation [in German]","volume":"373","year":"1988","journal-title":"Langenbecks Arch Chir"},{"key":"lt24135-bib-0003-20240115","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1097\/00000658-200112000-00002","article-title":"Is there still a need for living\u2010related liver transplantation in children?","volume":"234","year":"2001","journal-title":"Ann Surg"},{"key":"lt24135-bib-0004-20240115","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/00000658-199007000-00003","article-title":"Transplantation of two patients with one liver. 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