{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:36:13Z","timestamp":1791826573778,"version":"4.3.4"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","license":[{"start":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T00:00:00Z","timestamp":1437696000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T00:00:00Z","timestamp":1437696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>The demand for transplantable organs far outweighs the supply. Recently, efforts have been made to increase the donor pool by adopting extended criteria for livers, including those from hypernatremic donors. Currently, there is no clear evidence that the use of organs from hypernatremic donors has detrimental effects on pediatric liver transplantation (LT) recipients. Our aim was to use the Scientific Registry of Transplant Recipients database to evaluate the effects of donor hypernatremia on 30\u2010day outcomes in pediatric LT recipients. We performed an analysis of 2325 children who underwent whole or partial LT between 2005 and 2010. First, we sought to determine a donor sodium threshold for increased mortality following pediatric LT. Second, we examined rates of mortality and graft failure at 30 days after LT in patients receiving grafts from hypernatremic donors compared to patients receiving grafts from normonatremic donors. Hypernatremia was defined as a donor sodium level of \u2265160 \u00b5mol\/L. The primary outcome measure was mortality at 30 days after transplant. The secondary outcome measure was graft failure at 30 days after transplant. There was no threshold sodium level for increased 30\u2010day mortality following pediatric LT. Mean recipient ages\/weights, Pediatric End\u2010Stage Liver Disease\/Model for End\u2010Stage Liver Disease scores, and mean cold and warm ischemia times were similar between the 2 study groups. There were no significant differences in mortality rates (3.9% versus 4.5%; <jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.87) and graft failure rates (2.2% versus 1.9%; <jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20091.00) in patients receiving grafts from hypernatremic donors compared to patients receiving grafts from normonatremic donors at 30 days after LT. In conclusion, donor hypernatremia just before procurement does not appear to have negative effects on mortality and graft failure rates at 30 days following pediatric LT. <jats:italic toggle=\"yes\">Liver Transpl 21:1076\u20101081, 2015<\/jats:italic>. \u00a9 2015 AASLD.<\/jats:p>","DOI":"10.1002\/lt.24145","type":"journal-article","created":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T07:11:07Z","timestamp":1429773067000},"page":"1076-1081","source":"Crossref","is-referenced-by-count":20,"title":["Donor hypernatremia before procurement and early outcomes following pediatric liver transplantation"],"prefix":"10.1097","volume":"21","author":[{"given":"Neema","family":"Kaseje","sequence":"first","affiliation":[{"name":"Divisions of Pediatric Surgery,University Hospitals Geneva,Geneva,Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"McLin","sequence":"additional","affiliation":[{"name":"Division of Pediatrics,University Hospitals Geneva,Geneva,Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Toso","sequence":"additional","affiliation":[{"name":"Division of Surgery,University Hospitals Geneva,Geneva,Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Poncet","sequence":"additional","affiliation":[{"name":"Division of Center for Epidemiology,University Hospitals Geneva,Geneva,Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara E.","family":"Wildhaber","sequence":"additional","affiliation":[{"name":"Divisions of Pediatric Surgery,University Hospitals Geneva,Geneva,Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2015,7,24]]},"reference":[{"key":"lt24145-bib-0001-20240115","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1177\/152692480401400310","article-title":"Factors during donor care that may affect liver 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donor\u2010recipient serum sodium differences and orthotopic liver transplant graft function","volume":"1","year":"2008","journal-title":"Liver Transpl"},{"key":"lt24145-bib-0009-20240115","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1097\/TP.0b013e3181e764c0","article-title":"Severe hypernatremia in deceased liver donors does not impact early transplant outcome","volume":"90","year":"2010","journal-title":"Transplantation"},{"key":"lt24145-bib-0010-20240115","first-page":"8","article-title":"Donor hypernatremia influences outcomes following pediatric liver transplantation","volume":"23","year":"2013","journal-title":"Eur J Pediatr Surg"},{"key":"lt24145-bib-0011-20240115","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1111\/j.1600-6143.2007.01787.x","article-title":"2006 SRTR report on the state of transplantation","volume":"7","year":"2007","journal-title":"Am J Transplant"},{"key":"lt24145-bib-0012-20240115","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1097\/01.sla.0000234896.18207.fa","article-title":"Use of extended criteria livers decreases wait time for liver transplantation without adversely impacting posttransplant survival","volume":"244","year":"2006","journal-title":"Ann Surg"},{"key":"lt24145-bib-0013-20240115","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1097\/01.sla.0000183973.49899.b1","article-title":"Utilization of extended donor criteria liver allografts maximizes donor use and patient access to liver transplantation","volume":"242","year":"2005","journal-title":"Ann Surg"},{"key":"lt24145-bib-0014-20240115","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1016\/j.transproceed.2012.07.113","article-title":"Extremely marginal liver grafts from deceased donors have outcome similar to ideal grafts","volume":"44","year":"2012","journal-title":"Transplant 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