{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T06:55:16Z","timestamp":1778741716835,"version":"3.51.4"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["KO8 DK088946"],"award-info":[{"award-number":["KO8 DK088946"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R03 DK102480"],"award-info":[{"award-number":["R03 DK102480"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>The survival benefit of simultaneous liver\u2010kidney transplantation (SLKT) over liver transplantation alone (LTA) is unclear from the current literature. Additionally, the role of donor kidney quality, measured by the kidney donor risk index (KDRI), in survival benefit of SLKT is not studied. We compared survival benefit after SLKT and LTA among recipients with similar pretransplant renal dysfunction using novel methodology, specifically with respect to survival probability and area under the survival curve by dialysis status and KDRI. Data were obtained from the Scientific Registry of Transplant Recipients. The study cohort included patients with pre\u2013liver transplantation (LT) renal dysfunction who were wait\u2010listed and received either a SLKT (n\u2009=\u20091326) or a LTA (n\u2009=\u20094283) between March 1, 2002 and December 31, 2009. Inverse Probability of Treatment Weighting\u2013SLKT and LTA survival curves, along with the 5\u2010year area under the survival curve, were computed by dialysis status at transplant. The difference in the area under the curve represents the average additional survival time gained via SLKT over LTA. For patients not on dialysis, SLKT resulted in a significant 3.7\u2010month gain in 5\u2010year mean posttransplant survival time. The decrease in mortality rate differs significantly by KDRI, and an estimated 76% of SLKT recipients received a kidney with KDRI sufficiently low for mortality. The mortality decrease for SLKT was concentrated in the first year after transplant. The difference between SLKT and LTA 5\u2010year mean posttransplant survival time was 1.4 months and was nonsignificant for patients on dialysis. In conclusion, the propensity score\u2010adjusted survival among SLKT and LTA recipients was similar for those who were on dialysis at LT. Although statistically significant, the survival advantage of SLKT over LTA was of marginal clinical significance among patients not on dialysis and occurred only if the donor kidney was of sufficient quality. These results should be considered in the ongoing debate regarding the allocation of kidneys to extra\u2010renal transplant candidates. <jats:italic toggle=\"yes\">Liver Transpl 22:71\u201079, 2016<\/jats:italic>. \u00a9 2015 AASLD.<\/jats:p>","DOI":"10.1002\/lt.24189","type":"journal-article","created":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T13:22:19Z","timestamp":1433942539000},"page":"71-79","source":"Crossref","is-referenced-by-count":66,"title":["Propensity score\u2010based survival benefit of simultaneous liver\u2010kidney transplant over liver transplant alone for recipients with pretransplant renal dysfunction"],"prefix":"10.1097","volume":"22","author":[{"given":"Pratima","family":"Sharma","sequence":"first","affiliation":[{"name":"Division of Gastroenterology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Shu","sequence":"additional","affiliation":[{"name":"Biostatistics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas E.","family":"Schaubel","sequence":"additional","affiliation":[{"name":"Biostatistics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randall S.","family":"Sung","sequence":"additional","affiliation":[{"name":"Surgery,University of Michigan,Ann Arbor,MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Magee","sequence":"additional","affiliation":[{"name":"Surgery,University of Michigan,Ann Arbor,MI"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2015,12,28]]},"reference":[{"key":"lt24189-bib-0002-20240115","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1053\/jlts.2001.25879","article-title":"MELD and PELD: application of survival 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