{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:52:02Z","timestamp":1761630722628,"version":"3.37.3"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":39,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK076565"],"award-info":[{"award-number":["DK076565"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>Donor age has become the dominant donor factor used to predict graft failure (GF) after liver transplantation (LT) in hepatitis C virus (HCV) recipients. The purpose of this study was to develop and validate a model of corrected donor age (CDA) for HCV LT recipients that transforms the risk of other donor factors into the scale of donor age. We analyzed all first LT recipients with HCV in the United Network for Organ Sharing (UNOS) registry from January 1998 to December 2007 (development cohort, n\u2009=\u200914,538) and January 2008 to December 2011 (validation cohort, n\u2009=\u20097502) using Cox regression, excluding early GF (&lt;90 days from LT). Accuracy in predicting 1 year GF (death or repeat LT) was assessed with the net reclassification index (NRI). In the development cohort, after controlling for pre\u2010LT recipient factors and geotemporal trends (UNOS region, LT year), the following donor factors were independent predictors of GF, all <jats:italic toggle=\"yes\">P<\/jats:italic>\u2009&lt;\u20090.05: donor age (hazard ratio [HR], 1.02\/year), donation after cardiac death (DCD; HR, 1.31), diabetes (HR, 1.23), height\u2009&lt;\u2009160 cm (HR, 1.13), aspartate aminotransferase (AST)\u2009\u2265\u2009120 U\/L (HR, 1.10), female (HR, 0.94), cold ischemia time (CIT; HR, 1.02\/hour), and non\u2013African American (non\u2010AA) donor\u2013African American (AA) recipient (HR, 1.65). Transforming these risk factors into the donor age scale yielded the following: DCD\u2009=\u2009+16 years; diabetes\u2009=\u2009+12 years; height\u2009&lt;\u2009160 cm\u2009=\u2009+7 years; AST\u2009\u2265\u2009120 U\/L\u2009=\u2009+5 years; female\u2009=\u2009\u20134 years; and CIT\u2009=\u2009+1 year\/hour\u2009&gt;\u20098 hours and \u22121 year\/hour\u2009&lt;\u20098 hours. There was a large effect of donor\u2010recipient race combinations: +29 years for non\u2010AA donor and an AA recipient but only +5 years for an AA donor and an AA recipient, and \u22122 years for an AA donor and a non\u2010AA recipient. In a validation cohort, CDA better classified risk of 1\u2010year GF versus actual age (NRI, 4.9%; <jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.009) and versus the donor risk index (9.0%, <jats:italic toggle=\"yes\">P<\/jats:italic>\u2009&lt;\u20090.001). The CDA, compared to actual donor age, provides an intuitive and superior estimation of graft quality for HCV\u2010positive LT recipients because it incorporates additional factors that impact LT GF rates. <jats:italic toggle=\"yes\">Liver Transpl 21:1022\u20101030, 2015<\/jats:italic>. \u00a9 2015 AASLD.<\/jats:p>","DOI":"10.1002\/lt.24194","type":"journal-article","created":{"date-parts":[[2015,6,13]],"date-time":"2015-06-13T08:19:08Z","timestamp":1434183548000},"page":"1022-1030","source":"Crossref","is-referenced-by-count":6,"title":["The corrected donor age for hepatitis C virus\u2013infected liver transplant recipients"],"prefix":"10.1097","volume":"21","author":[{"given":"Melisa","family":"Dirchwolf","sequence":"first","affiliation":[{"name":"Hepatopat\u00edas Infecciosas,Hospital Francisco J. Mu\u00f1iz, Buenos Aires,Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer L.","family":"Dodge","sequence":"additional","affiliation":[{"name":"University of California San Francisco, Department of Surgery,San Francisco,CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Gralla","sequence":"additional","affiliation":[{"name":"University of Colorado,Departments of Pediatrics and Biostatistics and Informatics, Anschutz Medical Campus,Aurora,CO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiran M.","family":"Bambha","sequence":"additional","affiliation":[{"name":"University of Colorado, Division of Gastroenterology and Hepatology, Anschutz Medical Campus,Aurora,CO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trevor","family":"Nydam","sequence":"additional","affiliation":[{"name":"University of Colorado, Department of Surgery, Anschutz Medical Campus,Aurora,CO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth W.","family":"Hung","sequence":"additional","affiliation":[{"name":"University of Colorado, Division of Gastroenterology and Hepatology, Anschutz Medical Campus,Aurora,CO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo R.","family":"Rosen","sequence":"additional","affiliation":[{"name":"University of Colorado, Division of Gastroenterology and Hepatology, Anschutz Medical Campus,Aurora,CO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandy","family":"Feng","sequence":"additional","affiliation":[{"name":"University of California San Francisco, Department of Surgery,San Francisco,CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norah A.","family":"Terrault","sequence":"additional","affiliation":[{"name":"University of California San Francisco, Division of Gastroenterology and Hepatology,San Francisco,CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott W.","family":"Biggins","sequence":"additional","affiliation":[{"name":"University of Colorado, Division of Gastroenterology and Hepatology, Anschutz Medical Campus,Aurora,CO"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2015,7,24]]},"reference":[{"key":"lt24194-bib-0001-20240115","first-page":"87","article-title":"Challenges of organ shortage for transplantation: solutions and opportunities","volume":"5","year":"2014","journal-title":"Int J Organ Transplant Med"},{"journal-title":"Liver Transpl","article-title":"Declining liver graft quality threatens the future of liver transplantation in the United States","year":"2015","key":"lt24194-bib-0002-20240115"},{"key":"lt24194-bib-0003-20240115","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/j.1600-6143.2006.01242.x","article-title":"Characteristics associated with liver graft 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hepatitis","volume":"5","year":"2005","journal-title":"Am J Transplant"},{"key":"lt24194-bib-0007-20240115","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1097\/01.TP.0000095896.07048.BB","article-title":"Donor age affects fibrosis progression and graft survival after liver transplantation for hepatitis C","volume":"77","year":"2004","journal-title":"Transplantation"},{"key":"lt24194-bib-0008-20240115","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/j.1432-2277.2012.01474.x","article-title":"How can we utilize livers from advanced aged donors for liver transplantation for hepatitis C?","volume":"25","year":"2012","journal-title":"Transpl Int"},{"key":"lt24194-bib-0009-20240115","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1002\/lt.23937","article-title":"Restricting liver transplant recipients to younger donors does not increase the wait\u2010list time or the dropout rate: the hepatitis C 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Hepatitis C can be cured globally, but at what cost?","volume":"345","year":"2014","journal-title":"Science"},{"key":"lt24194-bib-0032-20240115","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.antiviral.2015.01.004","article-title":"A path to eradication of hepatitis C in low\u2010 and middle\u2010income countries","volume":"119","year":"2015","journal-title":"Antiviral Res"},{"key":"lt24194-bib-0033-20240115","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/TP.0000000000000198","article-title":"Liver transplantation in Latin America: the state\u2010of\u2010the\u2010art and future trends","volume":"98","year":"2014","journal-title":"Transplantation"},{"key":"lt24194-bib-0034-20240115","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/cld.438","article-title":"New therapies for hepatitis C: Latin American perspectives","volume":"5","year":"2015","journal-title":"Clin Liver Dis"}],"container-title":["Liver Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flt.24194","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01445473-201508000-00004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T03:00:55Z","timestamp":1705287655000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01445473-201508000-00004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,24]]},"references-count":34,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1002\/lt.24194","relation":{},"ISSN":["1527-6465","1527-6473"],"issn-type":[{"type":"print","value":"1527-6465"},{"type":"electronic","value":"1527-6473"}],"subject":[],"published":{"date-parts":[[2015,7,24]]}}}