{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:09:05Z","timestamp":1786118945907,"version":"build-2736575974"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Aspergillus<\/jats:italic>\n                    infection remains a significant and deadly complication after liver transplantation (LT). We sought to determine whether the antifungal prophylactic use of voriconazole reduces the incidence of invasive aspergillosis (IA) in high\u2010risk LT recipients without prohibitively increasing cost. During the study era (April 2008 to April 2014), 339 deceased donor LTs were performed. Of those patients, 174 high\u2010risk recipients were administered antifungal prophylaxis with voriconazole. The median biological Model for End\u2010Stage Liver Disease score at the time of LT was 33 (range, 18\u201049) with 56% requiring continuous renal replacement therapy and 50% requiring ventilatory support immediately before transplantation. Diagnosis of IA was stratified as proven, probable, or possible according to previously published definitions. No IA was documented in patients receiving voriconazole prophylaxis. At 90 days after LT, the institutional cost of prophylaxis was $5324 or 5.6% of the predicted cost associated with post\u2010LT aspergillosis. There was no documentation of resistant strains isolated from any recipient who received voriconazole. In conclusion, these data suggest that voriconazole prophylaxis is safe, clinically effective, and cost\u2010effective in high\u2010risk LT recipients.\n                    <jats:italic toggle=\"yes\">Liver Transpl 22:163\u2013170, 2016<\/jats:italic>\n                    . \u00a9 2015 AASLD.\n                  <\/jats:p>","DOI":"10.1002\/lt.24365","type":"journal-article","created":{"date-parts":[[2015,10,29]],"date-time":"2015-10-29T20:24:42Z","timestamp":1446150282000},"page":"163-170","source":"Crossref","is-referenced-by-count":30,"title":["Efficacy and cost\u2010effectiveness of voriconazole prophylaxis for prevention of invasive aspergillosis in high\u2010risk liver transplant recipients"],"prefix":"10.1097","volume":"22","author":[{"given":"Julius","family":"Balogh","sequence":"first","affiliation":[{"name":"Sherrie and Alan Conover Center for Liver Disease and Transplantation"},{"name":"Divisions of Transplantation, Department of Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherilyn","family":"Gordon Burroughs","sequence":"additional","affiliation":[{"name":"Sherrie and Alan Conover Center for Liver Disease and Transplantation"},{"name":"Divisions of Transplantation, Department of Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha","family":"Boktour","sequence":"additional","affiliation":[{"name":"Sherrie and Alan Conover Center for Liver Disease and Transplantation"},{"name":"Divisions of Transplantation, Department of Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Patel","sequence":"additional","affiliation":[{"name":"Sherrie and Alan Conover Center for Liver Disease and Transplantation"},{"name":"Divisions of Transplantation, Department of Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Saharia","sequence":"additional","affiliation":[{"name":"Sherrie and Alan Conover Center for Liver Disease and Transplantation"},{"name":"Divisions of Transplantation, Department of Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Ochoa","sequence":"additional","affiliation":[{"name":"Sherrie and Alan Conover Center for Liver Disease and Transplantation"},{"name":"Divisions of Transplantation, Department of Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"McFadden","sequence":"additional","affiliation":[{"name":"Sherrie and Alan Conover Center for Liver Disease and Transplantation"},{"name":"Divisions of Hepatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Victor","sequence":"additional","affiliation":[{"name":"Sherrie and Alan Conover Center for Liver Disease and Transplantation"},{"name":"Divisions of Hepatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Ankoma\u2010Sey","sequence":"additional","affiliation":[{"name":"Sherrie and Alan Conover Center for Liver Disease and Transplantation"},{"name":"Divisions of Hepatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Galati","sequence":"additional","affiliation":[{"name":"Sherrie and Alan Conover Center for Liver Disease and Transplantation"},{"name":"Divisions of Hepatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard P.","family":"Monsour","sequence":"additional","affiliation":[{"name":"Sherrie and Alan Conover Center for Liver Disease and Transplantation"},{"name":"Divisions of Hepatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Fainstein","sequence":"additional","affiliation":[{"name":"Sherrie and Alan Conover Center for Liver Disease and Transplantation"},{"name":"Divisions of Infectious Disease, Department of Medicine,Houston Methodist Hospital,Houston,TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian C.","family":"Li","sequence":"additional","affiliation":[{"name":"Sherrie and Alan Conover Center for Liver Disease and Transplantation"},{"name":"Divisions of Transplantation, Department of Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin A.","family":"Grimes","sequence":"additional","affiliation":[{"name":"Sherrie and Alan Conover Center for Liver Disease and Transplantation"},{"name":"Divisions of Infectious Disease, Department of Medicine,Houston Methodist Hospital,Houston,TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Osama","family":"Gaber","sequence":"additional","affiliation":[{"name":"Sherrie and Alan Conover Center for Liver Disease and Transplantation"},{"name":"Divisions of Transplantation, Department of Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Aloia","sequence":"additional","affiliation":[{"name":"MD Anderson Cancer Center,University of Texas,Houston,TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Mark","family":"Ghobrial","sequence":"additional","affiliation":[{"name":"Sherrie and Alan Conover Center for Liver Disease and Transplantation"},{"name":"Divisions of Transplantation, Department of Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2016,1,8]]},"reference":[{"key":"lt24365-bib-0001-20240115","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1600-6143.2007.02089.x","article-title":"Antifungal management practices in liver transplant recipients","volume":"8","year":"2008","journal-title":"Am J Transplant"},{"key":"lt24365-bib-0002-20240115","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1002\/lt.20690","article-title":"Antifungal prophylaxis in liver transplant patients: a systematic review and meta\u2010analysis","volume":"12","year":"2006","journal-title":"Liver 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