{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:17:34Z","timestamp":1791393454807,"version":"4.3.3"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p>Liver stiffness measurement (LSM) is a useful method to estimate liver fibrosis and portal hypertension. The inflammatory process that takes place in post\u2013liver transplant acute cellular rejection (ACR) may also increase liver stiffness. We aimed to explore the association between liver stiffness and the severity of ACR, as well as to assess the relationship between liver stiffness and response to rejection treatment in a prospective study that included 27 liver recipients with biopsy\u2010proven ACR, 30 stable recipients with normal liver tests, and 30 hepatitis C virus (HCV)\u2013infected LT recipients with histologically diagnosed HCV recurrence. Patients with rejection were stratified into 2 groups (mild and moderate\/severe) according to the severity of rejection evaluated with the Banff score. Routine biomarkers and LSM with FibroScan were performed at the time of liver biopsy (baseline) and at 7, 30, and 90 days in patients with rejection and at baseline in control patients. Median baseline liver stiffness was 5.9 kPa in the mild rejection group, 11 kPa in the moderate\/severe group (<jats:italic toggle=\"yes\">P<\/jats:italic>= 0.001), 4.2 kPa in stable recipients (<jats:italic toggle=\"yes\">P<\/jats:italic>= 0.02 versus mild rejection), and 13.6 kPa in patients with recurrent HCV (<jats:italic toggle=\"yes\">P<\/jats:italic>= 0.17 versus moderate\/severe rejection). The area under the receiver operator characteristic curve of LSM to discriminate mild versus moderate\/severe ACR was 0.924, and a LSM value of 8.5 kPa yielded a positive predictive value of 100% to diagnose moderate\/severe rejection. Liver stiffness improved in 7%, 21%, and 64% of patients with moderate\/severe rejection at 7, 30, and 90 days. In conclusion, according to the results of this exploratory study, LSM is associated with the severity of ACR in liver transplantation and thus may be of help in its assessment.<jats:italic toggle=\"yes\">Liver Transpl 22:298\u2013304, 2016<\/jats:italic>. \u00a9 2015 AASLD.<\/jats:p>","DOI":"10.1002\/lt.24376","type":"journal-article","created":{"date-parts":[[2015,11,26]],"date-time":"2015-11-26T23:21:14Z","timestamp":1448580074000},"page":"298-304","source":"Crossref","is-referenced-by-count":43,"title":["Usefulness of liver stiffness measurement during acute cellular rejection in liver transplantation"],"prefix":"10.1097","volume":"22","author":[{"given":"Gonzalo","family":"Crespo","sequence":"first","affiliation":[{"name":"Liver Unit,University of Barcelona,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciela","family":"Castro\u2010Narro","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology,Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n,Mexico DF,Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Garc\u00eda\u2010Ju\u00e1rez","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology,Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n,Mexico DF,Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Ben\u00edtez","sequence":"additional","affiliation":[{"name":"Liver Transplant Unit,Pontificia Universidad Cat\u00f3lica de Chile,Santiago de Chile,Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Liver Unit,University of Barcelona,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Sastre","sequence":"additional","affiliation":[{"name":"Liver Unit,University of Barcelona,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Colmenero","sequence":"additional","affiliation":[{"name":"Liver Unit,University of Barcelona,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Miquel","sequence":"additional","affiliation":[{"name":"Pathology Department,Hospital Cl\u00ednic, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas, University of Barcelona,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"S\u00e1nchez\u2010Fueyo","sequence":"additional","affiliation":[{"name":"Institute of Liver Studies,King's College,London,UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Forns","sequence":"additional","affiliation":[{"name":"Liver Unit,University of Barcelona,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miquel","family":"Navasa","sequence":"additional","affiliation":[{"name":"Liver Unit,University of Barcelona,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2016,2,15]]},"reference":[{"key":"lt24376-bib-0001-20240115","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1600-6143.2008.02487.x","article-title":"Incidence and severity of acute cellular rejection in recipients undergoing adult living donor or deceased donor liver transplantation","volume":"9","year":"2009","journal-title":"Am J Transplant"},{"key":"lt24376-bib-0002-20240115","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/hep.510250328","article-title":"Banff schema for grading liver allograft rejection: an international consensus 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cholestasis increases liver stiffness (FibroScan) irrespective of fibrosis","volume":"48","year":"2008","journal-title":"Hepatology"},{"key":"lt24376-bib-0010-20240115","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.jhep.2014.04.045","article-title":"Steatosis affects the performance of liver stiffness measurement for fibrosis assessment in patients with genotype 1 chronic hepatitis C","volume":"61","year":"2014","journal-title":"J Hepatol"},{"key":"lt24376-bib-0012-20240115","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1097\/00007890-199503150-00018","article-title":"Receiver operating characteristic analysis of serum chemical parameters as tests of liver transplant rejection and correlation with histology","volume":"59","year":"1995","journal-title":"Transplantation"},{"key":"lt24376-bib-0013-20240115","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1034\/j.1600-6143.2003.00083.x","article-title":"Applications and limitations of blood eosinophilia for the diagnosis of acute cellular rejection in liver transplantation","volume":"3","year":"2003","journal-title":"Am J Transplant"},{"key":"lt24376-bib-0014-20240115","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/j.1432-2277.2012.01457.x","article-title":"Predicting severity and clinical course of acute rejection after liver transplantation using blood eosinophil count","volume":"25","year":"2012","journal-title":"Transpl Int"},{"key":"lt24376-bib-0015-20240115","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/tri.12514","article-title":"Lack of agreement for defining \u201cclinical suspicion of rejection\u201d in liver transplantation: a model to select candidates for liver biopsy","volume":"28","year":"2015","journal-title":"Transpl Int"},{"key":"lt24376-bib-0016-20240115","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/hepr.12012","article-title":"Biomarkers for the diagnosis of acute cellular rejection in liver 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