{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T05:03:48Z","timestamp":1705295028076},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T00:00:00Z","timestamp":1464220800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"award":["2009A179"],"award-info":[{"award-number":["2009A179"]}]},{"award":["20090833B41"],"award-info":[{"award-number":["20090833B41"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p>To test the alternative possible locations for the placement of a liver graft and the relevant surgical technique issues, we developed a porcine model of auxiliary partial heterotopic liver transplantation (APHLT) and evaluated the difference between 2 styles of liver transplantation, either subhepatic fossa or splenic fossa APHLT, by comparing survival and biochemical indexes. Thirty\u2010eight miniature pigs were randomly divided into 2 groups. A left hemihepatic graft without the middle hepatic vein (HV) was procured from the living donor. In group A (n\u2009=\u20099), an 8 mm diameter polytetrafluoroethylene (PTFE) graft approximately 2.5 cm long was connected to the left HV while another PTFE graft of the same size was connected to the left portal vein (PV). The liver graft was implanted in the right subhepatic fossa following splenectomy and right nephrectomy. In group B (n\u2009=\u200910), a PTFE graft of the same size was connected to the left HV while the liver graft was implanted in the splenic fossa following splenectomy and left nephrectomy. Survival rate and complications were observed at 2 weeks after transplantation. Data were collected from 5 animals in group A and 6 animals in group B that survived longer than 2 weeks. The liver function and renal function of the recipients returned to normal at 1 week after surgery in both groups. Eighty\u2010eight percent (14\/16) of the PTFE grafts remained patent at 2 weeks after surgery, but 44% of the PTFE grafts (7\/16) developed mural thrombus. No significant differences in the survival rate and biochemistry were found between the 2 groups. In conclusion, the splenic fossa APHLT can achieve beneficial outcomes similar to the subhepatic fossa APHLT in miniature pigs, although it also has a high morbidity rate due to hepatic artery thrombosis, PV thrombosis, and PTEF graft mural thrombus formation. <jats:italic toggle=\"yes\">Liver Transplantation 22 812\u2013821 2016 AASLD<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/lt.24397","type":"journal-article","created":{"date-parts":[[2016,1,19]],"date-time":"2016-01-19T23:41:00Z","timestamp":1453246860000},"page":"812-821","source":"Crossref","is-referenced-by-count":0,"title":["A Comparison between splenic fossa and subhepatic fossa auxiliary partial heterotopic liver transplantation in a porcine model"],"prefix":"10.1097","volume":"22","author":[{"given":"Lemin","family":"Ai","sequence":"first","affiliation":[{"name":"Department of General Surgery,The People's First Hospital of Xiaoshan,Hangzhou,Zhejiang Province,People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine,Zhejiang University,Hangzhou,Zhejiang Province,People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhifei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery,Zhejiang Province People's Hospital,Hangzhou,Zhejiang Province,People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of General Surgery,The People's First Hospital of Xiaoshan,Hangzhou,Zhejiang Province,People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feiyan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of General Surgery,The People's First Hospital of Xiaoshan,Hangzhou,Zhejiang Province,People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Limei","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of General Surgery,The People's First Hospital of Xiaoshan,Hangzhou,Zhejiang Province,People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongming","family":"Pan","sequence":"additional","affiliation":[{"name":"Laboratory Animal Research Center,Zhejiang Chinese Medical University,Hangzhou,Zhejiang Province,People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine,Zhejiang University,Hangzhou,Zhejiang Province,People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2016,5,26]]},"reference":[{"key":"lt24397-bib-0001-20240115","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1097\/MOT.0b013e32834a94cf","article-title":"Auxiliary liver transplantation in children","volume":"16","year":"2011","journal-title":"Curr Opin Organ Transplant"},{"key":"lt24397-bib-0002-20240115","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1002\/lt.20131","article-title":"Feasibility of auxiliary partial orthotopic liver transplantation from living donors for patients with adult\u2010onset type II citrullinemia","volume":"10","year":"2004","journal-title":"Liver Transpl"},{"key":"lt24397-bib-0003-20240115","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/j.1600-6143.2005.00717.x","article-title":"Auxiliary partial orthotopic living donor liver transplantation: Kyoto University experience","volume":"5","year":"2005","journal-title":"Am J Transplant"},{"key":"lt24397-bib-0004-20240115","first-page":"244","article-title":"Homotransplantation of the canine liver","volume":"39","year":"1956","journal-title":"Surgery"},{"key":"lt24397-bib-0005-20240115","first-page":"279","article-title":"Partial resection of liver grafts for orthotopic or heterotopic liver transplantation","volume":"17","year":"1985","journal-title":"Transplant Proc"},{"key":"lt24397-bib-0006-20240115","first-page":"699","article-title":"European Auxiliary Liver Transplant Registry","volume":"30","year":"1999","journal-title":"J Hepatol"},{"key":"lt24397-bib-0007-20240115","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1097\/00000658-200112000-00003","article-title":"Auxiliary partial orthotopic versus standard orthotopic whole liver transplantation for acute liver failure: a reappraisal from a single center by a case\u2010control study","volume":"234","year":"2001","journal-title":"Ann Surg"},{"key":"lt24397-bib-0008-20240115","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1002\/lt.20376","article-title":"Heterotopic vs. orthotopic liver transplantation for chronic liver disease: a case\u2010control comparison of short\u2010term and long\u2010term outcomes","volume":"11","year":"2005","journal-title":"Liver Transpl"},{"key":"lt24397-bib-0009-20240115","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1097\/00007890-198806000-00001","article-title":"Auxiliary heterotopic liver transplantation","volume":"45","year":"1988","journal-title":"Transplantation"},{"key":"lt24397-bib-0010-20240115","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1111\/j.1399-3046.2007.00823.x","article-title":"Long\u2010term survival in a patient after heterotopic segmental auxiliary liver transplantation","volume":"12","year":"2008","journal-title":"Pediatr Transplant"},{"key":"lt24397-bib-0011-20240115","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1111\/j.1600-6143.2007.01959.x","article-title":"Reuse of auxiliary liver grafts in second recipients with chronic liver disease","volume":"7","year":"2007","journal-title":"Am J Transplant"},{"key":"lt24397-bib-0012-20240115","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1016\/S0041-1345(98)00997-X","article-title":"A new, stable model of left lobectomy for living\u2010related liver transplantation in the pig","volume":"30","year":"1998","journal-title":"Transplant Proc"},{"key":"lt24397-bib-0013-20240115","first-page":"188","article-title":"Auxiliary transplantation of a partial liver graft in the dog and the pig","volume":"35","year":"1983","journal-title":"Neth J Surg"},{"key":"lt24397-bib-0014-20240115","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1097\/00000658-198611000-00008","article-title":"Hemodynamics and coagulation in experimental auxiliary liver transplantation during fulminant hepatic failure","volume":"204","year":"1986","journal-title":"Ann Surg"},{"key":"lt24397-bib-0015-20240115","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/0140-6736(93)91542-T","article-title":"Temporary auxiliary liver transplantation for subacute liver failure in a child","volume":"342","year":"1993","journal-title":"Lancet"},{"key":"lt24397-bib-0016-20240115","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1006\/jsre.1995.1062","article-title":"Auxiliary heterotopic liver graft using splenopancreatic venous blood flow in pig","volume":"58","year":"1995","journal-title":"J Surg Res"},{"key":"lt24397-bib-0017-20240115","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1002\/lt.22053","article-title":"Late reuse of liver allografts from brain\u2010dead graft recipients: the Munich experience and a review of the literature","volume":"16","year":"2010","journal-title":"Liver Transpl"},{"key":"lt24397-bib-0018-20240115","first-page":"179","article-title":"The origin, hormonal nature, and action of hepatotrophic substances in portal venous blood","volume":"137","year":"1973","journal-title":"Surg Gynecol Obstet"},{"key":"lt24397-bib-0019-20240115","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1136\/bmj.4.5630.535","article-title":"Liver transplantation in man. I. Observations on technique and organization in five cases","volume":"4","year":"1968","journal-title":"Br Med J"},{"key":"lt24397-bib-0020-20240115","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1016\/S0041-1345(00)01676-6","article-title":"Splenectomy and auxiliary liver transplantation","volume":"32","year":"2000","journal-title":"Transplant Proc"},{"key":"lt24397-bib-0021-20240115","first-page":"1572","article-title":"Heterotopic liver transplantation in a case of cirrhosis with portal vein thrombosis","volume":"22","year":"1990","journal-title":"Transplant Proc"},{"key":"lt24397-bib-0022-20240115","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S1665-2681(19)30872-5","article-title":"A modified heterotopic auxiliary living donor liver transplantation: report of a case","volume":"13","year":"2014","journal-title":"Ann Hepatol"},{"key":"lt24397-bib-0023-20240115","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1053\/jlts.2000.18492","article-title":"Auxiliary heterotopic liver transplantation with portal vein arterialization for fulminant hepatic failure","volume":"6","year":"2000","journal-title":"Liver Transpl"},{"key":"lt24397-bib-0024-20240115","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1111\/j.1600-6143.2006.01538.x","article-title":"A novel technique for auxiliary partial liver transplantation with reno\u2010portal anastomosis and avoidance of the hepatoduodenal ligament","volume":"6","year":"2006","journal-title":"Am J Transplant"},{"key":"lt24397-bib-0025-20240115","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/S0022-3468(99)90165-3","article-title":"Directing portal flow is essential for graft survival in auxiliary partial heterotopic liver transplantation in the dog","volume":"34","year":"1999","journal-title":"J Pediatr Surg"},{"key":"lt24397-bib-0026-20240115","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1097\/SLA.0b013e3181bdfef6","article-title":"Auxiliary liver transplantation for acute liver failure in children","volume":"251","year":"2010","journal-title":"Ann Surg"},{"key":"lt24397-bib-0027-20240115","first-page":"101","article-title":"How can we share the portal blood inflow in auxiliary partial heterotopic liver transplantation without portal hypertension?","volume":"116","year":"1994","journal-title":"Surgery"},{"key":"lt24397-bib-0028-20240115","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/petr.12436","article-title":"Portal flow modulation in auxiliary partial orthotopic liver transplantation","volume":"19","year":"2015","journal-title":"Pediatr Transplant"},{"key":"lt24397-bib-0029-20240115","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1111\/j.1600-6143.2012.03997.x","article-title":"\u201cLeft at right\u201d adult liver transplantation: the feasibility of heterotopic implantation of left liver graft","volume":"12","year":"2012","journal-title":"Am J Transplant"},{"key":"lt24397-bib-0030-20240115","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00534-005-1019-7","article-title":"Techniques of reconstruction of hepatic veins in living\u2010donor liver transplantation, especially for right hepatic vein and major short hepatic veins of right\u2010lobe graft","volume":"13","year":"2006","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"lt24397-bib-0031-20240115","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1002\/lt.23456","article-title":"Usability of ringed polytetrafluoroethylene grafts for middle hepatic vein reconstruction during living donor liver transplantation","volume":"18","year":"2012","journal-title":"Liver Transpl"},{"key":"lt24397-bib-0032-20240115","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1002\/lt.21213","article-title":"An artificial vascular graft is a useful interpositional material for drainage of the right anterior section in living donor liver transplantation","volume":"13","year":"2007","journal-title":"Liver Transpl"}],"container-title":["Liver Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flt.24397","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flt.24397","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lt.24397","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lt.24397","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01445473-201606000-00016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T01:10:18Z","timestamp":1705281018000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01445473-201606000-00016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,26]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1002\/lt.24397","relation":{},"ISSN":["1527-6465","1527-6473"],"issn-type":[{"value":"1527-6465","type":"print"},{"value":"1527-6473","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,26]]}}}