{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:38:01Z","timestamp":1790743081953,"version":"4.1.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>Donation after circulatory death (DCD) liver transplantation (LT) may imply a risk for decreased graft survival, caused by posttransplantation complications such as primary nonfunction or ischemic\u2010type biliary lesions. However, similar survival rates for DCD and donation after brain death (DBD) LT have been reported. The objective of this study is to determine the longterm outcome of DCD LT in the Eurotransplant region corrected for the Eurotransplant donor risk index (ET\u2010DRI). Transplants performed in Belgium and the Netherlands (January 1, 2003 to December 31, 2007) in adult recipients were included. Graft failure was defined as either the date of recipient death or retransplantation whichever occurred first (death\u2010uncensored graft survival). Mean follow\u2010up was 7.2 years. In total, 126 DCD and 1264 DBD LTs were performed. Kaplan\u2010Meier survival analyses showed different graft survival for DBD and DCD at 1 year (77.7% versus 74.8%, respectively; <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.71), 5 years (65.6% versus 54.4%, respectively; <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.02), and 10 years (47.3% versus 44.2%, respectively; <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.55; log\u2010rank <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.038). Although there was an overall significant difference, the survival curves almost reach each other after 10 years, which is most likely caused by other risk factors being less in DCD livers. Patient survival was not significantly different (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.59). Multivariate Cox regression analysis showed a hazard ratio of 1.7 (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001) for DCD (corrected for ET\u2010DRI and recipient factors). First warm ischemia time (WIT), which is the time from the end of circulation until aortic cold perfusion, over 25 minutes was associated with a lower graft survival in univariate analysis of all DCD transplants (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.002). In conclusion, DCD LT has an increased risk for diminished graft survival compared to DBD. There was no significant difference in patient survival. DCD allografts with a first WIT &gt; 25 minutes have an increased risk for a decrease in graft survival. <jats:italic toggle=\"yes\">Liver Transplantation 22 1107\u20131114 2016 AASLD<\/jats:italic>\n                        <\/jats:p>","DOI":"10.1002\/lt.24449","type":"journal-article","created":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T00:47:05Z","timestamp":1459385225000},"page":"1107-1114","source":"Crossref","is-referenced-by-count":94,"title":["Longterm results of liver transplantation from donation after circulatory death"],"prefix":"10.1097","volume":"22","author":[{"given":"Joris J.","family":"Blok","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Transplantation, Leiden University Medical Center,Leiden University,Leiden,the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Detry","sequence":"additional","affiliation":[{"name":"Department of Abdominal Surgery and Transplantation,University Hospital of Li\u00e8ge,Li\u00e8ge,Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hein","family":"Putter","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, Leiden University Medical Center,Leiden University,Leiden,the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Rogiers","sequence":"additional","affiliation":[{"name":"Department of Surgery,Ghent University Hospital Medical School,Ghent,Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Porte","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Groningen,University Medical Center Groningen,Groningen,the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"van Hoek","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Leiden University Medical Center,Leiden University,Leiden,the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Pirenne","sequence":"additional","affiliation":[{"name":"Department of Abdominal Transplant Surgery,University Hospitals Leuven,Leuven,Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herold J.","family":"Metselaar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology,Erasmus University Medical Center,Rotterdam,the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan P.","family":"Lerut","sequence":"additional","affiliation":[{"name":"Starzl Unit of Abdominal Transplantation, Department of Abdominal Surgery and Transplantation,University Hospitals Saint Luc,Brussels,Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk K.","family":"Ysebaert","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary, Transplantation and Endocrine Surgery,Antwerp University Hospital,Antwerp University,Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Lucidi","sequence":"additional","affiliation":[{"name":"Department of Abdominal Surgery, Hepatobiliary and Liver Transplantation Unit,Erasme Hospital ULB,Brussels,Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto I.","family":"Troisi","sequence":"additional","affiliation":[{"name":"Department of Surgery,Ghent University Hospital Medical School,Ghent,Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Undine","family":"Samuel","sequence":"additional","affiliation":[{"name":"Eurotransplant International Foundation,Leiden,the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Claire","family":"den Dulk","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Leiden University Medical Center,Leiden University,Leiden,the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Ringers","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Transplantation, Leiden University Medical Center,Leiden University,Leiden,the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andries E.","family":"Braat","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Transplantation, Leiden University Medical Center,Leiden University,Leiden,the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Eurotransplant Liver Intestine Advisory 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