{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:47:37Z","timestamp":1791571657471,"version":"4.3.4"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>The role of prostaglandin E1 (PGE1) infusion in improving early graft function has not been well defined, especially in the scenario of living donor liver transplantation (LDLT). We designed a randomized, double\u2010blind, placebo\u2010controlled trial to evaluate the role of perioperative PGE1 infusion in LDLT. Patients in the study arm received PGE1 (alprostadil) at the rate of 0.25 \u03bcg\/kg\/hour, starting at 1 hour after portal venous reperfusion, and continued for 96 hours. The primary endpoint was early allograft dysfunction (EAD). We analyzed multiple secondary endpoints including postoperative liver function and renal function parameters, acute kidney injury (AKI), hepatic artery thrombosis (HAT), postoperative bleeding, overall mortality, and posttransplant hospital stay. The incidence of EAD was lower in the PGE1 arm, although the difference did not reach statistical significance (22.4% versus 36%;<jats:italic toggle=\"yes\">P<\/jats:italic>= 0.21). Among the secondary endpoints, the incidence of AKI was significantly lower in the PGE1 arm (8.2% versus 28%;<jats:italic toggle=\"yes\">P<\/jats:italic>= 0.02), as were the peak and mean postoperative creatinine levels. The need for renal replacement therapy was similar between the 2 groups. Among the postoperative graft function parameters, postoperative alanine aminotransferase level was significantly lower in the PGE1 arm (<jats:italic toggle=\"yes\">P<\/jats:italic>= 0.04), whereas the remaining parameters including serum bilirubin, aspartate aminotransferase, and international normalized ratio were similar between the 2 arms. There was no difference in the incidence of HAT and postoperative bleeding, in\u2010hospital mortality, and posttransplant hospital stay between the 2 arms. Perioperative PGE1 infusion reduces the incidence of posttransplant renal dysfunction in patients undergoing LDLT.<jats:italic toggle=\"yes\">Liver Transplantation 22 1067\u20131074 2016 AASLD<\/jats:italic><\/jats:p>","DOI":"10.1002\/lt.24479","type":"journal-article","created":{"date-parts":[[2016,5,6]],"date-time":"2016-05-06T17:23:28Z","timestamp":1462555408000},"page":"1067-1074","source":"Crossref","is-referenced-by-count":27,"title":["Perioperative prostaglandin e1 infusion in living donor liver transplantation: A double\u2010blind, placebo\u2010controlled randomized trial"],"prefix":"10.1097","volume":"22","author":[{"given":"Viju Kumar","family":"Bharathan","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery and Solid Organ Transplantation,Amrita Institute of Medical Sciences and Research Centre,Kochi,Kerala,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biju","family":"Chandran","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery and Solid Organ Transplantation,Amrita Institute of Medical Sciences and Research Centre,Kochi,Kerala,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Unnikrishnan","family":"Gopalakrishnan","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery and Solid Organ Transplantation,Amrita Institute of Medical Sciences and Research Centre,Kochi,Kerala,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christi Titus","family":"Varghese","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery and Solid Organ Transplantation,Amrita Institute of Medical Sciences and Research Centre,Kochi,Kerala,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramachandran N.","family":"Menon","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery and Solid Organ Transplantation,Amrita Institute of Medical Sciences and Research Centre,Kochi,Kerala,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh","family":"Balakrishnan","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery and Solid Organ Transplantation,Amrita Institute of Medical Sciences and Research Centre,Kochi,Kerala,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. V.","family":"Sudheer","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery and Solid Organ Transplantation,Amrita Institute of Medical Sciences and Research Centre,Kochi,Kerala,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puneet","family":"Dhar","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery and Solid Organ Transplantation,Amrita Institute of Medical Sciences and Research Centre,Kochi,Kerala,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhindran","family":"Surendran","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery and Solid Organ Transplantation,Amrita Institute of Medical Sciences and Research 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