{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T20:43:09Z","timestamp":1759178589881},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p>Liver transplantation (LT) activity started in Spain in 1984 and has exceeded 23,700 interventions, with more than 1000 transplants performed yearly. Every hospital needs official authorization to perform a LT, which implies the obligation to register all patients on the national waiting list. The Spanish National Transplant Organization (ONT) provides essential support for organ procurement, allocation, and management of the waiting list at a national level. Liver allocation is center\u2010oriented as all available organs are referred to the ONT for the whole country. The allocation rules for LT are made according to disease severity after consensus among professionals from every transplant center and ratified by representatives of the regional health authorities. Authorization and location\/distribution of transplant centers are regulated by the country (Spain) and by the different regions according to the Real Decreto 1723\/2012. For a total population of 47,850,795 inhabitants, there are 24 centers for LT for adults (1 team\/2 million people) and 5 for LT for children (1 team\/9.5 million people). Nonbiliary cirrhosis, particularly alcohol\u2010 and hepatitis C virus\u2013related cirrhosis (60%), and tumors, mainly hepatocellular carcinoma (19%), are the most common indications for LT in Spain. Unusual causes of LT include metabolic diseases like Wilson's disease, familial amyloid polyneuropathy and hyperoxaluria type I, polycystic kidney and liver disease, and some tumors (epithelioid hemangioendothelioma and neuroendocrine tumors). Important efforts are now being undertaken to improve the quality and transplantability of extended criteria livers, in particular those arising from DCD, which represent the greatest opportunity to expand the donor pool. These efforts have to be addressed to adapt the organ preservation procedures, be it through the application of regional perfusion in situ or the use of machine perfusion preservation ex situ. <jats:italic toggle=\"yes\">Liver Transplantation 22 1259\u20131264 2016 AASLD<\/jats:italic>\n                        <\/jats:p>","DOI":"10.1002\/lt.24484","type":"journal-article","created":{"date-parts":[[2016,5,21]],"date-time":"2016-05-21T15:28:38Z","timestamp":1463844518000},"page":"1259-1264","source":"Crossref","is-referenced-by-count":22,"title":["Liver transplantation in Spain"],"prefix":"10.1097","volume":"22","author":[{"given":"Gloria","family":"de la Rosa","sequence":"first","affiliation":[{"name":"Spanish National Transplant Organization,Barcelona,Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantino","family":"Fondevila","sequence":"additional","affiliation":[{"name":"Liver Transplant Unit, Hospital Cl\u00ednic, Universitat de Barcelona, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas,Barcelona,Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miquel","family":"Navasa","sequence":"additional","affiliation":[{"name":"Liver Transplant Unit, Hospital Cl\u00ednic, Universitat de Barcelona, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas,Barcelona,Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2016,7,22]]},"reference":[{"key":"lt24484-bib-0003-20240115","first-page":"337","article-title":"Valdivieso A for en representaci\u00f3n del Registro Espa\u00f1ol de Trasplante Hep\u00e1tico. Activity and results of liver transplantation in Spain during 1984\u20102012. Analysis of the Spanish Liver Transplant Registry","volume":"144","year":"2015","journal-title":"Med Clin (Barc)"},{"key":"lt24484-bib-0008-20240115","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1111\/j.1600-6143.2012.04138.x","article-title":"Continuously evaluating performance in deceased donation: the Spanish quality assurance program","volume":"12","year":"2012","journal-title":"Am J Transplant"},{"key":"lt24484-bib-0009-20240115","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1432-2277.2010.01204.x","article-title":"Spanish experience as a leading country: what kind of measures were taken?","volume":"24","year":"2011","journal-title":"Transpl Int"},{"key":"lt24484-bib-0010-20240115","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1016\/j.transproceed.2009.09.011","article-title":"The 40 donors per million population plan: an action plan for improvement of organ donation and transplantation in Spain","volume":"41","year":"2009","journal-title":"Transplant Proc"},{"key":"lt24484-bib-0014-20240115","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1111\/j.1600-6143.2007.01846.x","article-title":"Liver transplant using donors after unexpected cardiac death: novel preservation protocol and acceptance criteria","volume":"7","year":"2007","journal-title":"Am J Transplant"},{"key":"lt24484-bib-0015-20240115","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1600-6143.2011.03834.x","article-title":"Applicability and results of Maastricht type 2 donation after cardiac death liver transplantation","volume":"12","year":"2012","journal-title":"Am J Transplant"},{"key":"lt24484-bib-0016-20240115","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/lt.24107","article-title":"First experience of liver transplantation with type 2 donation after cardiac death in France","volume":"21","year":"2015","journal-title":"Liver Transpl"},{"key":"lt24484-bib-0017-20240115","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1111\/ajt.12927","article-title":"In situ normothermic regional perfusion for controlled donation after circulatory death\u2010\u2010the United Kingdom experience","volume":"14","year":"2014","journal-title":"Am J Transplant"},{"key":"lt24484-bib-0018-20240115","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1111\/tri.12344","article-title":"Hypothermic or normothermic abdominal regional perfusion in high\u2010risk donors with extended warm ischemia times: impact on outcomes?","volume":"28","year":"2015","journal-title":"Transpl Int"},{"issue":"suppl 2","key":"lt24484-bib-0019-20240115","first-page":"S9","article-title":"A bridge too far: we have not overstepped the line for extended deceased donors","volume":"20","year":"2014","journal-title":"Liver Transpl"},{"key":"lt24484-bib-0020-20240115","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.jhep.2012.10.020","article-title":"Donor\u2010recipient matching: myths and realities","volume":"58","year":"2013","journal-title":"J Hepatol"},{"key":"lt24484-bib-0021-20240115","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/ajt.12958","article-title":"Hypothermic machine preservation facilitates successful transplantation of \u201corphan\u201d extended criteria donor livers","volume":"15","year":"2015","journal-title":"Am J Transplant"},{"key":"lt24484-bib-0022-20240115","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/ajt.13448","article-title":"Preimplant normothermic liver perfusion of a suboptimal liver donated after circulatory death","volume":"16","year":"2016","journal-title":"Am J Transplant"},{"key":"lt24484-bib-0023-20240115","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.jhep.2014.04.031","article-title":"Biomarkers to assess graft quality during conventional and machine preservation in liver transplantation","volume":"61","year":"2014","journal-title":"J Hepatol"}],"container-title":["Liver Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flt.24484","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01445473-201609000-00014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T01:29:21Z","timestamp":1705282161000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01445473-201609000-00014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,22]]},"references-count":14,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1002\/lt.24484","relation":{},"ISSN":["1527-6465","1527-6473"],"issn-type":[{"value":"1527-6465","type":"print"},{"value":"1527-6473","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,22]]}}}