{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T21:16:46Z","timestamp":1777238206819,"version":"3.51.4"},"reference-count":72,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p>Approximately 10% of children with autoimmune hepatitis (AIH) and 30% of those with sclerosing cholangitis (SC) require liver transplantation (LT). LT is indicated in patients who present with fulminant hepatic failure (ie, with encephalopathy) and in those who develop end\u2010stage liver disease despite treatment. After LT, recurrent AIH is reported in approximately 30% of patients and recurrent SC in up to 50%. Diagnosis of recurrence is based on biochemical abnormalities, seropositivity for autoantibodies, interface hepatitis on histology, steroid dependence, and, for SC, presence of cholangiopathy. Recurrence of SC after LT is often associated with poorly controlled inflammatory bowel disease (IBD). Recurrence may even appear years after LT; therefore, steroid\u2010based immunosuppression should be maintained at a higher dose than that used for patients transplanted for nonautoimmune liver diseases. Although the impact of recurrent disease on graft function is controversial, it seems that in pediatric LT recipients recurrence of AIH or SC is associated with compromised graft survival. Exacerbation of preexistent IBD may be observed after LT for SC or AIH, and IBD appears to have a more aggressive course than before LT. In addition, IBD can develop de novo following LT. <jats:italic toggle=\"yes\">Liver Transplantation 22 1275\u20131283 2016 AASLD<\/jats:italic>\n                        <\/jats:p>","DOI":"10.1002\/lt.24490","type":"journal-article","created":{"date-parts":[[2016,6,3]],"date-time":"2016-06-03T15:42:41Z","timestamp":1464968561000},"page":"1275-1283","source":"Crossref","is-referenced-by-count":18,"title":["Recurrence of autoimmune liver disease and inflammatory bowel disease after pediatric liver transplantation"],"prefix":"10.1097","volume":"22","author":[{"given":"Rodrigo","family":"Liberal","sequence":"first","affiliation":[{"name":"Institute of Liver Studies and Transplantation,King's College London School of Medicine, King's College Hospital,London,UK"},{"name":"Department of Gastroenterology,Centro Hospitalar S\u00e3o Jo\u00e3o, Faculty of Medicine, University of Porto,Porto,Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Vergani","sequence":"additional","affiliation":[{"name":"Institute of Liver Studies and Transplantation,King's College London School of Medicine, King's College Hospital,London,UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgina","family":"Mieli\u2010Vergani","sequence":"additional","affiliation":[{"name":"Institute of Liver Studies and Transplantation,King's College London School of Medicine, King's College Hospital,London,UK"},{"name":"Paediatric Liver,GI and Nutrition Centre, King's College Hospital,London,UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2016,8,1]]},"reference":[{"key":"lt24490-bib-0001-20240115","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/hep.27191","article-title":"Evaluation of the pediatric patient for liver transplantation: 2014 practice guideline by the 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