{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T18:15:11Z","timestamp":1793556911110,"version":"4.5.0"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p>Young children\u2009&lt;\u20092 years of age with chronic end\u2010stage liver disease (YC2) are a uniquely vulnerable group listed for liver transplantation, characterized by a predominance of biliary atresia (BA). To investigate wait\u2010list mortality, associated risk factors, and outcomes of YC2, we evaluated United Network for Organ Sharing registry data from April 2003 to March 2013 for YC2 listed for deceased donor transplant (BA\u2009=\u2009994; other chronic liver disease [CLD]\u2009=\u2009221). Overall, wait\u2010list mortality among YC2 was 12.4% and posttransplant mortality was 8%, accounting for an overall postlisting mortality of 19.6%. YC2 demonstrated 12.2%, 18.7%, and 20.6% wait\u2010list mortality by 90, 180, and 270 days, respectively. YC2 with CLD demonstrated significantly higher wait\u2010list mortality compared with BA among YC2 (23.9% versus 9.8%; <jats:italic toggle=\"yes\">P<\/jats:italic>\u2009&lt;\u20090.05). Multivariate analyses revealed that listing Pediatric End\u2010Stage Liver Disease [PELD]\u2009&gt;\u200921 (hazard ratio [HR], 3.2; 95% confidence interval [CI], 1.6\u20106.5), lack of exception (HR, 5.8; 95% CI, 2.8\u201011.8), listing height\u2009&lt;\u200960.6\u2009cm (HR, 2.1; 95% CI, 1.4\u20103.1), listing weight \u2009&gt;\u200910\u2009kg (HR, 3.8; 95% CI, 1.5\u20109.2), and initial creatinine\u2009&gt;\u20090.5 (HR, 6.8; 95% CI, 3.4\u201013.5) were independent risk factors for YC2 wait\u2010list mortality (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009&lt;\u20090.005 for all). Adjusting for all variables, the risk of death among CLD patients was 2 (95% CI, 1.3\u20103.1) times greater than patients with BA\u2009+\u2009surgery (presumed Kasai). Furthermore, the risk of death in BA surgery was 1.9 (95% CI, 1\u20103.4) times greater than BA with presumed Kasai. Our data highlight unacceptably high wait\u2010list and early post\u2013liver transplant mortality in YC2 not predicted by PELD and suggest key risk factors deserving of further study in this age group. <jats:italic toggle=\"yes\">Liver Transplantation 22 1584\u20131592 2016 AASLD<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/lt.24605","type":"journal-article","created":{"date-parts":[[2016,8,19]],"date-time":"2016-08-19T17:56:43Z","timestamp":1471629403000},"page":"1584-1592","source":"Crossref","is-referenced-by-count":43,"title":["A 10\u2010Year united network for organ sharing review of mortality and risk factors in young children awaiting liver transplantation"],"prefix":"10.1097","volume":"22","author":[{"given":"Daniel H.","family":"Leung","sequence":"first","affiliation":[{"name":"Department of Pediatrics,Baylor College of Medicine,Houston,TX"},{"name":"Division of Pediatric Gastroenterology, Hepatology, and Nutrition,Texas Children's Hospital,Houston,TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrita","family":"Narang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics,Baylor College of Medicine,Houston,TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles G.","family":"Minard","sequence":"additional","affiliation":[{"name":"Dan L. Duncan Institute for Clinical and Translational Research,Houston,TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girish","family":"Hiremath","sequence":"additional","affiliation":[{"name":"Department of Pediatrics,Baylor College of Medicine,Houston,TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Goss","sequence":"additional","affiliation":[{"name":"Division of Abdominal Transplant Surgery, Baylor College of Medicine\/Texas Children's Hospital,Houston,TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross","family":"Shepherd","sequence":"additional","affiliation":[{"name":"Department of Pediatrics,Baylor College of Medicine,Houston,TX"},{"name":"Division of Pediatric Gastroenterology, Hepatology, and Nutrition,Texas Children's 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