{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T18:19:42Z","timestamp":1763057982856,"version":"3.41.0"},"reference-count":65,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>Renal failure is a late consequence of end\u2010stage liver disease (ESLD). Even with liver transplantation, pretransplant renal impairment remains a strong predictor of posttransplant mortality. This review seeks to summarize and critically appraise common therapies used in this setting, including pharmacologic agents, procedures (transjugular intrahepatic portosystemic shunt, renal replacement therapy), and simultaneous liver\u2010kidney transplantation. More experimental extracorporal modalities, eg, albumin dialysis or bioartificial livers, will not be discussed. A brief discussion on the definition and pathophysiologic underpinnings of renal failure in ESLD will be held at the beginning to lay the groundwork for the main section.<jats:italic toggle=\"yes\">Liver Transplantation 22 1710\u20131719 2016 AASLD<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/lt.24609","type":"journal-article","created":{"date-parts":[[2016,11,22]],"date-time":"2016-11-22T17:21:31Z","timestamp":1479835291000},"page":"1710-1719","source":"Crossref","is-referenced-by-count":12,"title":["Management of renal failure in end\u2010stage liver disease: A critical appraisal"],"prefix":"10.1097","volume":"22","author":[{"given":"Xingxing S.","family":"Cheng","sequence":"first","affiliation":[{"name":"Division of Nephrology,Stanford University,Palo Alto,CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane C.","family":"Tan","sequence":"additional","affiliation":[{"name":"Division of Nephrology,Stanford University,Palo Alto,CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. Ray","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology,Stanford University,Palo Alto,CA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2016,11,22]]},"reference":[{"key":"lt24609-bib-0001-20240115","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.jhep.2014.12.029","article-title":"Diagnosis and management of acute kidney injury in patients with cirrhosis: revised consensus recommendations of the International Club of Ascites","volume":"62","year":"2015","journal-title":"J Hepatol"},{"issue":"suppl","key":"lt24609-bib-0002-20240115","first-page":"1","article-title":"KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease 2013","volume":"3","year":"2013","journal-title":"Kidney Int"},{"key":"lt24609-bib-0003-20240115","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1093\/ndt\/gfr354","article-title":"Pitfalls in assessing renal function in patients with cirrhosis\u2013potential inequity for access to treatment of hepatorenal failure and liver transplantation","volume":"26","year":"2011","journal-title":"Nephrol Dial Transplant"},{"key":"lt24609-bib-0004-20240115","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1002\/hep.26886","article-title":"Creatinine\u2010 versus cystatine C\u2010based equations in assessing the renal function of candidates for liver transplantation with cirrhosis","volume":"59","year":"2014","journal-title":"Hepatology"},{"key":"lt24609-bib-0005-20240115","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1136\/gut.2010.236133","article-title":"Working Party proposal for a revised classification system of renal dysfunction in patients with cirrhosis","volume":"60","year":"2011","journal-title":"Gut"},{"key":"lt24609-bib-0006-20240115","doi-asserted-by":"crossref","first-page":"R23","DOI":"10.1186\/cc11188","article-title":"Hepatorenal syndrome: the 8th International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group","volume":"16","year":"2012","journal-title":"Crit Care"},{"key":"lt24609-bib-0007-20240115","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1093\/ndt\/gfh839","article-title":"Measured creatinine clearance from timed urine collections substantially overestimates glomerular filtration rate in patients with liver cirrhosis: a systematic review and individual patient meta\u2010analysis","volume":"20","year":"2005","journal-title":"Nephrol Dial Transplant"},{"key":"lt24609-bib-0008-20240115","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1002\/hep.26556","article-title":"Performance of chronic kidney disease epidemiology collaboration creatinine\u2010cystatin C equation for estimating kidney function in cirrhosis","volume":"59","year":"2014","journal-title":"Hepatology"},{"key":"lt24609-bib-0009-20240115","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.cgh.2015.06.021","article-title":"Estimation of glomerular filtration rate in patients with cirrhosis by using new and conventional filtration markers and dimethylarginines","volume":"14","year":"2016","journal-title":"Clin Gastroenterol Hepatol"},{"key":"lt24609-bib-0010-20240115","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1097\/TP.0000000000000552","article-title":"Serum cystatin C as an indicator of renal function and mortality in liver transplant recipients","volume":"99","year":"2015","journal-title":"Transplantation"},{"key":"lt24609-bib-0011-20240115","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jhep.2012.03.015","article-title":"Urinary neutrophil gelatinase\u2010associated lipocalin as biomarker in the differential diagnosis of impairment of kidney function in cirrhosis","volume":"57","year":"2012","journal-title":"J Hepatol"},{"key":"lt24609-bib-0012-20240115","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/hep.26980","article-title":"Kidney biomarkers and differential diagnosis of patients with cirrhosis and acute kidney injury","volume":"60","year":"2014","journal-title":"Hepatology"},{"key":"lt24609-bib-0013-20240115","doi-asserted-by":"crossref","first-page":"665","DOI":"10.2215\/CJN.04010907","article-title":"Urine NGAL predicts severity of acute kidney injury after cardiac surgery: a prospective study","volume":"3","year":"2008","journal-title":"Clin J Am Soc Nephrol"},{"key":"lt24609-bib-0014-20240115","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/SHK.0000000000000052","article-title":"A unified theory of sepsis\u2010induced acute kidney injury: inflammation, microcirculatory dysfunction, bioenergetics, and the tubular cell adaptation to injury","volume":"41","year":"2014","journal-title":"Shock"},{"key":"lt24609-bib-0015-20240115","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1002\/hep.510240527","article-title":"Transjugular renal biopsy in the treatment of patients with cirrhosis and renal abnormalities","volume":"24","year":"1996","journal-title":"Hepatology"},{"key":"lt24609-bib-0016-20240115","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1172\/JCI110777","article-title":"Changes in size, subclass, and metabolic properties of serum immunoglobulin A in liver diseases and in other diseases with high serum immunoglobulin A","volume":"71","year":"1983","journal-title":"J Clin Invest"},{"key":"lt24609-bib-0017-20240115","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/BF00873994","article-title":"Glomerular abnormalities in children undergoing orthotopic liver transplantation","volume":"6","year":"1992","journal-title":"Pediatr Nephrol"},{"key":"lt24609-bib-0018-20240115","doi-asserted-by":"crossref","first-page":"735","DOI":"10.7326\/0003-4819-144-10-200605160-00007","article-title":"Brief communication: Glomerulonephritis in patients with hepatitis C cirrhosis undergoing liver transplantation","volume":"144","year":"2006","journal-title":"Ann Intern Med"},{"issue":"suppl 1","key":"lt24609-bib-0019-20240115","first-page":"S69","article-title":"Ascites and hepatorenal syndrome in cirrhosis: pathophysiological basis of therapy and current management","volume":"38","year":"2003","journal-title":"J Hepatol"},{"issue":"suppl 1","key":"lt24609-bib-0020-20240115","first-page":"S6","article-title":"Pathophysiological basis of albumin use in cirrhosis","volume":"10","year":"2011","journal-title":"Ann Hepatol"},{"key":"lt24609-bib-0021-20240115","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1053\/j.gastro.2007.10.055","article-title":"Relationship between activation of the sympathetic nervous system and renal blood flow autoregulation in cirrhosis","volume":"134","year":"2008","journal-title":"Gastroenterology"},{"key":"lt24609-bib-0022-20240115","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0002-9343(70)80073-0","article-title":"Renal failure in the patient with cirrhosis. The role of active vasoconstriction","volume":"49","year":"1970","journal-title":"Am J Med"},{"key":"lt24609-bib-0023-20240115","first-page":"F521","article-title":"Renal perfusion in dogs with experimental hepatic cirrhosis: role of prostaglandins","volume":"245","year":"1983","journal-title":"Am J Physiol"},{"key":"lt24609-bib-0024-20240115","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.jhep.2015.07.004","article-title":"Mechanisms of decompensation and organ failure in cirrhosis: From peripheral arterial vasodilation to systemic inflammation hypothesis","volume":"63","year":"2015","journal-title":"J Hepatol"},{"key":"lt24609-bib-0025-20240115","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1056\/NEJMra064398","article-title":"Normotensive ischemic acute renal failure","volume":"357","year":"2007","journal-title":"N Engl J Med"},{"key":"lt24609-bib-0026-20240115","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1002\/hep.23775","article-title":"Deleterious effects of beta\u2010blockers on survival in patients with cirrhosis and refractory ascites","volume":"52","year":"2010","journal-title":"Hepatology"},{"key":"lt24609-bib-0027-20240115","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1053\/j.gastro.2014.03.005","article-title":"Nonselective \u03b2 blockers increase risk for hepatorenal syndrome and death in patients with cirrhosis and spontaneous bacterial peritonitis","volume":"146","year":"2014","journal-title":"Gastroenterology"},{"key":"lt24609-bib-0028-20240115","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1136\/gutjnl-2011-301348","article-title":"The window hypothesis: haemodynamic and non\u2010haemodynamic effects of \u03b2\u2010blockers improve survival of patients with cirrhosis during a window in the disease","volume":"61","year":"2012","journal-title":"Gut"},{"key":"lt24609-bib-0029-20240115","first-page":"822","article-title":"Determinants of deranged sodium and water homeostasis in decompensated cirrhosis","volume":"87","year":"1976","journal-title":"J Lab Clin Med"},{"key":"lt24609-bib-0030-20240115","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/0016-5085(88)90691-9","article-title":"Randomized comparative study of therapeutic paracentesis with and without intravenous albumin in cirrhosis","volume":"94","year":"1988","journal-title":"Gastroenterology"},{"key":"lt24609-bib-0031-20240115","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1056\/NEJM199908053410603","article-title":"Effect of intravenous albumin on renal impairment and mortality in patients with cirrhosis and spontaneous bacterial peritonitis","volume":"341","year":"1999","journal-title":"N Engl J Med"},{"key":"lt24609-bib-0032-20240115","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/S0016-5085(96)70068-9","article-title":"Randomized trial comparing albumin, dextran 70, and polygeline in cirrhotic patients with ascites treated by paracentesis","volume":"111","year":"1996","journal-title":"Gastroenterology"},{"key":"lt24609-bib-0033-20240115","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1111\/j.1440-1746.2009.06132.x","article-title":"Terlipressin therapy for reversal of type 1 hepatorenal syndrome: a meta\u2010analysis of randomized controlled trials","volume":"25","year":"2010","journal-title":"J Gastroenterol Hepatol"},{"key":"lt24609-bib-0034-20240115","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1053\/j.gastro.2016.02.026","article-title":"Terlipressin plus albumin is more effective than albumin alone in improving renal function in patients with cirrhosis and hepatorenal syndrome type 1","volume":"150","year":"2016","journal-title":"Gastroenterology"},{"key":"lt24609-bib-0035-20240115","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1053\/jhep.2002.34343","article-title":"Effects of noradrenalin and albumin in patients with type I hepatorenal syndrome: a pilot study","volume":"36","year":"2002","journal-title":"Hepatology"},{"key":"lt24609-bib-0036-20240115","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1002\/hep.510290629","article-title":"Reversal of type 1 hepatorenal syndrome with the administration of midodrine and octreotide","volume":"29","year":"1999","journal-title":"Hepatology"},{"key":"lt24609-bib-0037-20240115","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/ki.1985.142","article-title":"Interrelationship between cardiac output and vascular resistance as determinants of effective arterial blood volume in cirrhotic patients","volume":"28","year":"1985","journal-title":"Kidney Int"},{"key":"lt24609-bib-0038-20240115","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/hep.510270107","article-title":"Reversibility of hepatorenal syndrome by prolonged administration of ornipressin and plasma volume expansion","volume":"27","year":"1998","journal-title":"Hepatology"},{"key":"lt24609-bib-0039-20240115","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1053\/j.gastro.2016.04.020","article-title":"Management of hepatorenal syndrome in the era of acute\u2010on\u2010chronic liver failure: terlipressin and beyond","volume":"150","year":"2016","journal-title":"Gastroenterology"},{"key":"lt24609-bib-0040-20240115","doi-asserted-by":"crossref","first-page":"e107466","DOI":"10.1371\/journal.pone.0107466","article-title":"Terlipressin versus norepinephrine in the treatment of hepatorenal syndrome: a systematic review and meta\u2010analysis","volume":"9","year":"2014","journal-title":"PLoS One"},{"key":"lt24609-bib-0041-20240115","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/hep.27709","article-title":"for the Study of the Liver Study Group on Hepatorenal Syndrome. Terlipressin plus albumin versus midodrine and octreotide plus albumin in the treatment of hepatorenal syndrome: a randomized trial","volume":"62","year":"2015","journal-title":"Hepatology"},{"key":"lt24609-bib-0042-20240115","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0002-9343(99)00029-7","article-title":"Long\u2010term renal sodium handling in patients with cirrhosis treated with transjugular intrahepatic portosystemic shunts for refractory ascites","volume":"106","year":"1999","journal-title":"Am J Med"},{"key":"lt24609-bib-0043-20240115","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1136\/gut.47.2.288","article-title":"Long term outcome after transjugular intrahepatic portosystemic stent\u2010shunt in non\u2010transplant cirrhotics with hepatorenal syndrome: a phase II study","volume":"47","year":"2000","journal-title":"Gut"},{"key":"lt24609-bib-0044-20240115","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1056\/NEJMoa1603017","article-title":"Initiation strategies for renal\u2010replacement therapy in the intensive care unit","volume":"375","year":"2016","journal-title":"N Engl J Med"},{"key":"lt24609-bib-0045-20240115","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1056\/NEJMoa1000552","article-title":"A randomized, controlled trial of early versus late initiation of dialysis","volume":"363","year":"2010","journal-title":"N Engl J Med"},{"key":"lt24609-bib-0046-20240115","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/nrneph.2010.100","article-title":"Continuous renal replacement therapy: recent advances and future research","volume":"6","year":"2010","journal-title":"Nat Rev Nephrol"},{"key":"lt24609-bib-0047-20240115","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1046\/j.1492-7535.2003.00061.x","article-title":"Continuous renal replacement therapy for liver disease","volume":"7","year":"2003","journal-title":"Hemodial Int"},{"key":"lt24609-bib-0048-20240115","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1097\/MOT.0b013e328346c8a2","article-title":"The role of intraoperative hemodialysis in liver transplant patients","volume":"16","year":"2011","journal-title":"Curr Opin Organ Transplant"},{"key":"lt24609-bib-0049-20240115","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/lt.21650","article-title":"Intraoperative renal support during liver transplantation","volume":"15","year":"2009","journal-title":"Liver Transpl"},{"key":"lt24609-bib-0050-20240115","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1002\/lt.23867","article-title":"Intraoperative hemodialysis during liver transplantation: a decade of experience","volume":"20","year":"2014","journal-title":"Liver Transpl"},{"key":"lt24609-bib-0051-20240115","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1111\/ajt.12759","article-title":"Liver transplantation in recipients receiving renal replacement therapy: outcomes analysis and the role of intraoperative hemodialysis","volume":"14","year":"2014","journal-title":"Am J Transplant"},{"key":"lt24609-bib-0052-20240115","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1056\/NEJMoa021744","article-title":"Chronic renal failure after transplantation of a nonrenal organ","volume":"349","year":"2003","journal-title":"N Engl J Med"},{"key":"lt24609-bib-0053-20240115","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1097\/TP.0b013e318293fcf8","article-title":"New\u2010onset diabetes after transplantation (NODAT): an evaluation of definitions in clinical trials","volume":"96","year":"2013","journal-title":"Transplantation"},{"issue":"suppl 3","key":"lt24609-bib-0054-20240115","first-page":"S43","article-title":"Hot\u2010topic debate on kidney function: renal\u2010sparing approaches are beneficial","volume":"17","year":"2011","journal-title":"Liver Transpl"},{"key":"lt24609-bib-0055-20240115","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1600-6143.2008.02493.x","article-title":"Delayed introduction of reduced\u2010dose tacrolimus, and renal function in liver transplantation: the \u2018ReSpECT\u2019 study","volume":"9","year":"2009","journal-title":"Am J Transplant"},{"key":"lt24609-bib-0056-20240115","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1097\/TP.0000000000000779","article-title":"Calcineurin inhibitor free de novo immunosuppression in liver transplant recipients with pretransplant renal impairment: results of a Pilot Study (PATRON07)","volume":"99","year":"2015","journal-title":"Transplantation"},{"key":"lt24609-bib-0057-20240115","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1002\/lt.23672","article-title":"Early use of renal\u2010sparing agents in liver transplantation: a closer look","volume":"19","year":"2013","journal-title":"Liver Transpl"},{"key":"lt24609-bib-0058-20240115","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1111\/j.1600-6143.2006.01526.x","article-title":"Continued influence of preoperative renal function on outcome of orthotopic liver transplant (OLTX) in the US: where will MELD lead us?","volume":"6","year":"2006","journal-title":"Am J Transplant"},{"key":"lt24609-bib-0059-20240115","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/lt.24189","article-title":"Propensity score\u2010based survival benefit of simultaneous liver\u2010kidney transplant over liver transplant alone for recipients with pretransplant renal dysfunction","volume":"22","year":"2016","journal-title":"Liver Transpl"},{"key":"lt24609-bib-0060-20240115","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1056\/NEJM196906192802501","article-title":"Transplantation of cadaveric kidneys from patients with hepatorenal syndrome. Evidence for the functionalnature of renal failure in advanced liver disease","volume":"280","year":"1969","journal-title":"N Engl J Med"},{"key":"lt24609-bib-0061-20240115","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1056\/NEJM197311292892201","article-title":"Recovery from \u201chepatorenal syndrome\u201d after orthotopic liver transplantation","volume":"289","year":"1973","journal-title":"N Engl J Med"},{"key":"lt24609-bib-0062-20240115","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1002\/hep.26704","article-title":"Glomerular filtration rate equations for liver\u2010kidney transplantation in patients with cirrhosis: validation of current recommendations","volume":"59","year":"2014","journal-title":"Hepatology"},{"key":"lt24609-bib-0063-20240115","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/tri.12066","article-title":"Native renal function after combined liver\u2010kidney transplant for type 1 hepatorenal syndrome: initial report on the use of postoperative Technetium\u201099 m\u2010mercaptoacetyltriglycine scans","volume":"26","year":"2013","journal-title":"Transpl Int"},{"key":"lt24609-bib-0064-20240115","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.1111\/j.1600-6143.2012.04182.x","article-title":"Outcomes and native renal recovery following simultaneous liver\u2010kidney transplantation","volume":"12","year":"2012","journal-title":"Am J Transplant"},{"key":"lt24609-bib-0065-20240115","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1111\/ajt.13631","article-title":"Simultaneous liver\u2010kidney allocation policy: a proposal to optimize appropriate utilization of scarce resources","volume":"16","year":"2016","journal-title":"Am J Transplant"}],"container-title":["Liver Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flt.24609","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flt.24609","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01445473-201612000-00014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T20:23:12Z","timestamp":1749759792000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01445473-201612000-00014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,22]]},"references-count":65,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1002\/lt.24609","relation":{},"ISSN":["1527-6465","1527-6473"],"issn-type":[{"type":"print","value":"1527-6465"},{"type":"electronic","value":"1527-6473"}],"subject":[],"published":{"date-parts":[[2016,11,22]]}}}