{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T10:07:45Z","timestamp":1781690865958,"version":"3.54.5"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2016,12,30]],"date-time":"2016-12-30T00:00:00Z","timestamp":1483056000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2016,12,30]],"date-time":"2016-12-30T00:00:00Z","timestamp":1483056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p>The role of donation after cardiac death (DCD) in expanding the donor pool is mainly limited by the incidence of primary nonfunction (PNF) and ischemia\u2010related complications. Even greater concern exists toward uncontrolled DCD, which represents the largest potential pool of DCD donors. We recently started the first Italian series of DCD liver transplantation, using normothermic regional perfusion (NRP) in 6 uncontrolled donors and in 1 controlled case to deal with the legally required no\u2010touch period of 20 minutes. We examined our first 7 cases for the incidence of PNF, early graft dysfunction, and biliary complications. Acceptance of the graft was based on the trend of serum transaminase and lactate during NRP, the macroscopic appearance, and the liver biopsy. Hypothermic machine perfusion (HMP) was associated in selected cases to improve cold storage. Most notably, no cases of PNF were observed. Median posttransplant transaminase peak was 1014 IU\/L (range, 393\u20103268 IU\/L). Patient and graft survival were both 100% after a mean follow\u2010up of 6.1 months (range, 3\u20109 months). No cases of ischemic cholangiopathy occurred during the follow\u2010up. Only 1 anastomotic stricture completely resolved with endoscopic stenting. In conclusion, DCD liver transplantation is feasible in Italy despite the protracted no\u2010touch period. The use of NRP and HMP seems to earn good graft function and proves safe in these organs. <jats:italic toggle=\"yes\">Liver Transplantation 23 166\u2013173 2017 AASLD<\/jats:italic>\n                        <\/jats:p>","DOI":"10.1002\/lt.24666","type":"journal-article","created":{"date-parts":[[2016,12,30]],"date-time":"2016-12-30T22:55:02Z","timestamp":1483138502000},"page":"166-173","source":"Crossref","is-referenced-by-count":90,"title":["Successful donation after cardiac death liver transplants with prolonged warm ischemia time using normothermic regional perfusion"],"prefix":"10.1097","volume":"23","author":[{"given":"Riccardo","family":"De Carlis","sequence":"first","affiliation":[{"name":"Department of General Surgery and Transplantation,Niguarda Ca' Granda Hospital,Milan,Italy"},{"name":"Departments of Surgical Sciences,University of Pavia,Pavia,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Di Sandro","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Transplantation,Niguarda Ca' Granda Hospital,Milan,Italy"},{"name":"Departments of Experimental Medicine,University of Pavia,Pavia,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Lauterio","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Transplantation,Niguarda Ca' Granda Hospital,Milan,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Ferla","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Transplantation,Niguarda Ca' Granda Hospital,Milan,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Dell'Acqua","sequence":"additional","affiliation":[{"name":"Anestesia e Rianimazione,Istituto di Ricovero e Cura a Carattere Scientifico Ospedale San Raffaele,Milan,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinella","family":"Zanierato","sequence":"additional","affiliation":[{"name":"Anestesia e Rianimazione 1,Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo,Pavia,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"De Carlis","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Transplantation,Niguarda Ca' Granda Hospital,Milan,Italy"},{"name":"School of Medicine,University of Milano\u2010Bicocca,Milan,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2016,12,30]]},"reference":[{"key":"lt24666-bib-0001-20240115","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1097\/01.TP.0000062574.18648.7C","article-title":"Liver transplantation from controlled non\u2010heart\u2010beating donors: an increased incidence of biliary 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