{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:51:07Z","timestamp":1777510267402,"version":"3.51.4"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T00:00:00Z","timestamp":1485129600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T00:00:00Z","timestamp":1485129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p>The majority of pediatric patients with end\u2010stage liver disease receive a transplant with a whole liver (WL) allograft. However, smaller recipients with biliary atresia (BA) may have improved outcomes with deceased donor partial liver (DDPL) or living donor allografts. This study compares the national outcomes for liver transplantation in BA, with attention to the interaction between liver allograft type and recipient size. From January 2, 2002 to December 30, 2014, 2123 pediatric patients underwent a primary liver transplant for BA. The majority of transplants (53%) were performed with a WL allograft. Utilization of a WL allograft increased from 42% of recipients weighing\u2009\u2264\u20097\u2009kg to 74% of recipients weighing\u2009&gt;\u200914\u2009kg. The 1\u2010, 5\u2010, and 10\u2010year graft survival in recipients weighing \u22647\u2009kg was significantly superior for living donor liver transplantation (LDLT) (91%, 88%, 84%) and DDPL allografts (90%, 84%, 77%) compared with WL allografts (79%, 75%, 74%; <jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.005). The 1\u2010, 5\u2010, and 10\u2010year graft survival in recipients weighing &gt;14\u2009kg trended toward being inferior in recipients of DDPL allografts (85%, 85%, 71%) compared with WL allografts (96%, 91%, 86%; <jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.06). Furthermore, the incidence of vascular thrombosis was highest in WL (13%) compared with LDLT (6%) and DDPL (5%) recipients\u2009\u2264\u20097\u2009kg (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.002). Liver retransplantation was also highest in WL (16%) compared with LDLT (9%) and DDPL (9%) recipients\u2009\u2264\u20097\u2009kg (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.02). In conclusion, strong consideration should be given to the use of technical variant allografts in small recipients with BA requiring liver transplantation. <jats:italic toggle=\"yes\">Liver Transplantation 23 221\u2013233 2017 AASLD<\/jats:italic>\n                        <\/jats:p>","DOI":"10.1002\/lt.24675","type":"journal-article","created":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T13:26:04Z","timestamp":1479216364000},"page":"221-233","source":"Crossref","is-referenced-by-count":32,"title":["Effects of recipient size and allograft type on pediatric liver transplantation for biliary atresia"],"prefix":"10.1097","volume":"23","author":[{"given":"Sophoclis P.","family":"Alexopoulos","sequence":"first","affiliation":[{"name":"Department of Surgery, Keck School of Medicine,University of Southern California,Los Angeles,CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Nekrasov","sequence":"additional","affiliation":[{"name":"Department of Surgery, Keck School of Medicine,University of Southern California,Los Angeles,CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Keck School of Medicine,University of Southern California,Los Angeles,CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Groshen","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Keck School of Medicine,University of Southern California,Los Angeles,CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Navpreet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Surgery, Keck School of Medicine,University of Southern California,Los Angeles,CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuri S.","family":"Genyk","sequence":"additional","affiliation":[{"name":"Department of Surgery, Keck School of Medicine,University of Southern California,Los Angeles,CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lea","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Department of Surgery, Keck School of Medicine,University of Southern California,Los Angeles,CA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2017,1,23]]},"reference":[{"issue":"suppl 2","key":"lt24675-bib-0001-20240115","first-page":"1","article-title":"OPTN\/SRTR 2013 Annual Data Report: Liver","volume":"15","year":"2015","journal-title":"Am J Transplant"},{"key":"lt24675-bib-0002-20240115","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/BF01262776","article-title":"Transplantation einer Spenderleber auf zwei Empf\u00e4nger (Splitting\u2010Transplantation) \u2010 Eine neue Methode in der Weiterentwicklung der Lebersegmenttransplantation","volume":"373","year":"1988","journal-title":"Langenbecks Arch Chir"},{"key":"lt24675-bib-0003-20240115","first-page":"497","article-title":"Liver transplantation from live donors","volume":"2","year":"1989","journal-title":"Lancet"},{"key":"lt24675-bib-0004-20240115","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/SLA.0b013e31821ad86a","article-title":"A multivariate analysis of pre\u2010, peri\u2010, and post\u2010transplant factors affecting outcome after pediatric liver transplantation","volume":"254","year":"2011","journal-title":"Ann Surg"},{"key":"lt24675-bib-0005-20240115","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1002\/lt.20509","article-title":"Orthotopic liver transplantation for biliary atresia: the U.S. experience","volume":"11","year":"2005","journal-title":"Liver Transplant"},{"key":"lt24675-bib-0006-20240115","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.jpeds.2005.04.073","article-title":"Biliary atresia: clinical profiles, risk factors, and outcomes of 755 patients listed for 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A comparison of whole livers, reduced\u2010size grafts, and grafts from living\u2010related donors","volume":"53","year":"1992","journal-title":"Transplantation"},{"key":"lt24675-bib-0012-20240115","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0022-3468(95)90609-6","article-title":"Reduced\u2010size grafts\u2010\u2010the solution for hepatic artery thrombosis after pediatric liver transplantation?","volume":"30","year":"1995","journal-title":"J Pediatr Surg"},{"key":"lt24675-bib-0013-20240115","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1097\/00007890-200204270-00011","article-title":"Maintenance of the celiac trunk with the left\u2010sided liver allograft for in situ split\u2010liver transplantation","volume":"73","year":"2002","journal-title":"Transplantation"},{"key":"lt24675-bib-0014-20240115","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1161\/01.ATV.0000229658.76797.30","article-title":"Flow effects on coagulation and thrombosis","volume":"26","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"lt24675-bib-0015-20240115","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.jamcollsurg.2013.06.005","article-title":"Deceased\u2010donor split\u2010liver transplantation in adult recipients: is the learning curve over?","volume":"217","year":"2013","journal-title":"J Am Coll Surg"},{"key":"lt24675-bib-0016-20240115","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jamcollsurg.2013.03.003","article-title":"Outcomes with split liver transplantation are equivalent to those with whole organ transplantation","volume":"217","year":"2013","journal-title":"J Am Coll Surg"},{"key":"lt24675-bib-0017-20240115","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1111\/j.1600-6143.2005.00933.x","article-title":"Split\u2010liver transplantation: results of statewide usage of the right trisegmental graft","volume":"5","year":"2005","journal-title":"Am J Transplant"}],"container-title":["Liver Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flt.24675","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flt.24675","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01445473-201702000-00012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T01:35:35Z","timestamp":1705282535000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01445473-201702000-00012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,23]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1002\/lt.24675","relation":{},"ISSN":["1527-6465","1527-6473"],"issn-type":[{"value":"1527-6465","type":"print"},{"value":"1527-6473","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,23]]}}}